Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3',3'',5',5''-tetrabromophenolphthalein | - |
Oryctolagus cuniculus | |
benzbromarone | - |
Oryctolagus cuniculus | |
Flufenamic acid | - |
Oryctolagus cuniculus | |
galangin | - |
Oryctolagus cuniculus | |
Hexestrol | - |
Oryctolagus cuniculus | |
kaempferol | potent and competitive inhibitor | Oryctolagus cuniculus | |
Mefenamic acid | - |
Oryctolagus cuniculus | |
myricetin | - |
Oryctolagus cuniculus | |
naringenin | - |
Oryctolagus cuniculus | |
Phenolphthalein | - |
Oryctolagus cuniculus | |
quercetin | potent and competitive inhibitor | Oryctolagus cuniculus | |
Sulfobromophthalein | - |
Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
5alpha-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0006 | - |
progesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0006 | - |
isatin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0008 | - |
5alpha-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0009 | - |
Nonanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.001 | - |
4-androstene-3,17-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.001 | - |
5beta-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.001 | - |
5beta-Pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.001 | - |
4-pregnen-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.001 | - |
2-tert-butyl-1,4-benzoquinone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0011 | - |
estrone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0012 | - |
4-Nitroacetophenone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0013 | - |
17beta-estradiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0013 | - |
5alpha-pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0014 | - |
5beta-Androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0017 | - |
5beta-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0018 | - |
4-oxo-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.002 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0022 | - |
20alpha-hydroxyprogesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0022 | - |
5alpha-androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0025 | - |
5beta-Androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0026 | - |
5beta-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0028 | - |
5beta-androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0029 | - |
7alpha-hydroxy-dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0031 | - |
5-androstene-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0034 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0041 | - |
5alpha-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0042 | - |
dehydroepiandrosterone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0042 | - |
5alpha-androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0053 | - |
4-hydroxy-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0055 | - |
trans-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0057 | - |
5beta-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0059 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0059 | - |
4-oxo-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.006 | - |
dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.006 | - |
5alpha-Androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0062 | - |
5beta-androstan-17beta-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0062 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0067 | - |
Estrone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0074 | - |
trans-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0076 | - |
hexanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0078 | - |
5beta-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0089 | - |
all-trans-retinal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.011 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.013 | - |
testosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.014 | - |
acrolein | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.018 | - |
menadione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.018 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.018 | - |
beta-ionol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.019 | - |
diacetyl | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.034 | - |
befunolol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.053 | - |
alpha-tetralone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.061 | - |
pyridine 3-aldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.068 | - |
isocaproaldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.088 | - |
methylglyoxal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.111 | - |
ketotifen | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.112 | - |
(S)-1-tetralol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.131 | - |
(S)-1-indanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.152 | - |
4-chromanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.162 | - |
acetoin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.18 | - |
geraniol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.26 | - |
trans-benzene dihydrodiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.4 | - |
3-deoxyglucosone | at pH 7.4 and 37°C | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Sepharose 6FF resin column chromatography | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-1-indanol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
(S)-1-tetralol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
17beta-estradiol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
2-tert-butyl-1,4-benzoquinone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
20alpha-hydroxyprogesterone + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
3-deoxyglucosone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-androstene-3,17-dione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-chromanol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-hydroxy-2-nonenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-nitroacetophenone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-oxo-2-hexenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-oxo-2-nonenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
4-pregnen-3alpha-ol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5-androstene-3beta,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-androstan-3alpha-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-androstan-3beta,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-androstan-3beta-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-dihydrotestosterone + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-dihydrotestosterone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-pregnan-20alpha-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | 5beta-pregnan-3,20-dione + NADPH + H+ | - |
r | |
5alpha-pregnan-20alpha-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-pregnan-3,20-dione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-pregnan-3alpha,20alpha-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-pregnan-3alpha,21-diol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5alpha-pregnan-3alpha-ol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-androstan-17beta-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-androstan-3alpha,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-androstan-3alpha-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-androstan-3beta,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-androstan-3beta-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-pregnan-20alpha-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-pregnan-3,20-dione + NADPH + H+ | - |
Oryctolagus cuniculus | 5alpha-pregnan-20alpha-ol-3-one + NADP+ | - |
r | |
5beta-pregnan-3alpha,20alpha-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
5beta-pregnan-3alpha-ol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
7alpha-hydroxy-dehydroepiandrosterone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
acetoin + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
acrolein + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
all-trans-retinal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
alpha-tetralone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
befunolol + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
beta-ionol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
dehydroepiandrosterone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
dehydroepiandrosterone 3-sulfate + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
diacetyl + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
estrone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
estrone 3-sulfate + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
geraniol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
hexanal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
isatin + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
isocaproaldehyde + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
ketotifen + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
menadione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
methylglyoxal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
additional information | no activity with 5beta-androstan-17beta-ol-3-one, 5beta-pregnan-20alpha-ol-3-one, testosterone and 20alpha-hydroxy progesterone | Oryctolagus cuniculus | ? | - |
? | |
nonanal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
progesterone + NADPH + H+ | - |
Oryctolagus cuniculus | 20alpha-hydroxyprogesterone + NADP+ | - |
? | |
pyridine 3-aldehyde + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
testosterone + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
trans-2-hexenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
trans-2-nonenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
trans-benzene dihydrodiol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20alpha-HSD | - |
Oryctolagus cuniculus |
AKR1C5 | - |
Oryctolagus cuniculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0085 | - |
all-trans-retinal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.009 | - |
4-hydroxy-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.011 | - |
17beta-estradiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.0115 | - |
4-oxo-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.017 | - |
estrone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.017 | - |
5beta-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.018 | - |
5alpha-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.018 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.02 | - |
trans-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.02 | - |
ketotifen | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.023 | - |
isocaproaldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.025 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.025 | - |
trans-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.025 | - |
5alpha-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.027 | - |
progesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.028 | - |
5beta-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.03 | - |
5beta-Pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.032 | - |
Nonanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.032 | - |
5alpha-androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.032 | - |
5alpha-pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.032 | - |
4-pregnen-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.033 | - |
geraniol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.033 | - |
5beta-Androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.035 | - |
acrolein | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.043 | - |
hexanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.043 | - |
4-androstene-3,17-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.043 | - |
7alpha-hydroxy-dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.045 | - |
5beta-androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.047 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.048 | - |
20alpha-hydroxyprogesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.053 | - |
alpha-tetralone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.057 | - |
testosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.067 | - |
5beta-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.068 | - |
4-chromanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.077 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.08 | - |
dehydroepiandrosterone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.083 | - |
5alpha-Androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.085 | - |
5alpha-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.097 | - |
acetoin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.098 | - |
Estrone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.1 | - |
5-androstene-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.108 | - |
trans-benzene dihydrodiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.112 | - |
4-Nitroacetophenone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.112 | - |
4-oxo-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.117 | - |
befunolol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.12 | - |
methylglyoxal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.125 | - |
menadione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.132 | - |
pyridine 3-aldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.137 | - |
isatin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.153 | - |
5beta-androstan-17beta-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.153 | - |
5beta-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.155 | - |
dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.158 | - |
diacetyl | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.158 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.167 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.183 | - |
3-deoxyglucosone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.183 | - |
2-tert-butyl-1,4-benzoquinone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.2 | - |
(S)-1-indanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.217 | - |
(S)-1-tetralol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.233 | - |
beta-ionol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.25 | - |
5beta-Androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.27 | - |
5alpha-androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.283 | - |
5beta-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Oryctolagus cuniculus | |
NADPH | - |
Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000022 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Phenolphthalein | |
0.000059 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | quercetin | |
0.00011 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | kaempferol | |
0.00012 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | benzbromarone | |
0.00037 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | naringenin | |
0.00041 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | galangin | |
0.00064 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | myricetin | |
0.003 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | 3',3'',5',5''-tetrabromophenolphthalein | |
0.0064 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Hexestrol | |
0.01 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Mefenamic acid | |
0.011 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Sulfobromophthalein | |
0.026 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Flufenamic acid |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
geraniol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.062 | - |
4-oxo-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.13 | - |
3-deoxyglucosone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.18 | - |
ketotifen | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.35 | - |
isocaproaldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.42 | - |
trans-benzene dihydrodiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.45 | - |
4-chromanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
0.95 | - |
all-trans-retinal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1 | - |
alpha-tetralone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.3 | - |
acetoin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.3 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.4 | - |
methylglyoxal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.5 | - |
(S)-1-indanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.6 | - |
4-hydroxy-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.8 | - |
4-oxo-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
2 | - |
menadione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
2 | - |
(S)-1-tetralol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
2.2 | - |
pyridine 3-aldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
2.5 | - |
acrolein | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
2.7 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
3 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
3.3 | - |
trans-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
3.7 | - |
trans-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
4.3 | - |
testosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
5.7 | - |
hexanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
6.3 | - |
5beta-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
7.3 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
8.3 | - |
diacetyl | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
8.7 | - |
17beta-estradiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
10.1 | - |
beta-ionol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
13.2 | - |
befunolol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
13.3 | - |
5beta-Androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
13.8 | - |
5alpha-Androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
14.3 | - |
5alpha-androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
14.3 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
14.7 | - |
Estrone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
15 | - |
7alpha-hydroxy-dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
15.1 | - |
estrone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
16 | - |
5beta-androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
18.3 | - |
dehydroepiandrosterone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
20 | - |
5alpha-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
21.7 | - |
20alpha-hydroxyprogesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
25 | - |
5beta-androstan-17beta-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
25 | - |
5alpha-pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
26.7 | - |
dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
26.7 | - |
5beta-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
28.3 | - |
5beta-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
30 | - |
5beta-Pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
30 | - |
5alpha-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
31.7 | - |
5-androstene-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
31.7 | - |
4-pregnen-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
35 | - |
Nonanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
36.7 | - |
5alpha-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
36.7 | - |
5beta-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
40 | - |
5beta-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
43.3 | - |
4-androstene-3,17-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
45 | - |
progesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
63.3 | - |
5alpha-androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
83.3 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
93.3 | - |
4-Nitroacetophenone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
183.3 | - |
5beta-Androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
183.3 | - |
2-tert-butyl-1,4-benzoquinone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
233.3 | - |
isatin | at pH 7.4 and 37°C | Oryctolagus cuniculus |