Literature summary for 1.1.1.149 extracted from

Brown, K.A.; Boerboom, D.; Bouchard, N.; Dore, M.; Lussier, J.G.; Sirois, J.
Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo (2006), J. Mol. Endocrinol., 36, 449-461.

Search for more literature for 1.1.1.149

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	human chorionic gonadotropin induces expression of AKR1C23	Equus caballus

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, expression analysis of AKR1C23 in preovulatory follicles, overexpression in HEK-293 cells	Equus caballus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.003	0.012	17alpha-hydroxyprogesterone	-	Equus caballus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
17alpha-hydroxyprogesterone + NAD(P)H	Equus caballus	the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview	17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+	-	r

Organism

Organism	UniProt	Comment	Textmining
Equus caballus	Q1XAA8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	very low expression rate of AKR1C23	Equus caballus	-
brain	low expression rate of AKR1C23	Equus caballus	-
granulosa cell	-	Equus caballus	-
heart	moderate expression rate of AKR1C23	Equus caballus	-
kidney	moderate expression rate of AKR1C23	Equus caballus	-
liver	moderate expression rate of AKR1C23	Equus caballus	-
lung	moderate expression rate of AKR1C23	Equus caballus	-
ovarian follicle	preovulatory, very high expression rate, expression analysis of AKR1C23, activity during follicular luteinization, overview	Equus caballus	-
skeletal muscle	moderate expression rate of AKR1C23	Equus caballus	-
skin	very low expression rate of AKR1C23	Equus caballus	-
spleen	very low expression rate of AKR1C23	Equus caballus	-
stomach	low expression rate of AKR1C23	Equus caballus	-
testis	very high expression rate of AKR1C23	Equus caballus	-
thymus	very low expression rate of AKR1C23	Equus caballus	-
uterus	low expression rate of AKR1C23	Equus caballus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
17alpha-hydroxyprogesterone + NAD(P)H	-	Equus caballus	17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+	-	r
17alpha-hydroxyprogesterone + NAD(P)H	the aldo-keto reductase, AKR1C23, also shows 20alpha-hydroxysteroid dehydrogenase activity in vivo, enzyme regulation in preovulatory follicles and corpora lutea, overview	Equus caballus	17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+	-	r

Synonyms

Synonyms	Comment	Organism
AKR1C23	-	Equus caballus

Cofactor

Cofactor	Comment	Organism	Structure
NAD(P)+	-	Equus caballus
NAD(P)H	-	Equus caballus

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Release 2023.1 (January 2023)