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Literature summary for 1.1.1.149 extracted from

  • Hershkovitz, L.; Beuschlein, F.; Klammer, S.; Krup, M.; Weinstein, Y.
    Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone (2006), Endocrinology, 148, 976-988.
    View publication on PubMed
Search for more literature for 1.1.1.149

Application

Application Comment Organism
analysis the enzyme is a marker for the murine X-zone Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of 20alpha-HSD knockout animals, 20alpha-HSD is not required for the regulation of X-zone growth Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Mus musculus
0.0033
-
 11-deoxycorticosterone pH 7.4, 37°C Mus musculus
0.0058
-
 17alpha-hydroxyprogesterone pH 7.4, 37°C Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NAD(P)H Mus musculus progesterone catabolism 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
17alpha-hydroxyprogesterone + NAD(P)H Mus musculus BALB/c progesterone catabolism 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
additional information Mus musculus pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview ?
-
 ?
additional information Mus musculus BALB/c pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Balb/c mice
-
Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
 Mus musculus
-
adrenal gland high expression level, expression is restricted to the X-zone, adrenal 20alpha-HSD activity in male mice peaks at 3 weeks of age and disappears thereafter, whereas 20alpha-HSD enzyme activity is maintained in adrenals from nulliparous female animals Mus musculus
-
kidney
-
 Mus musculus
-
ovary high expression level Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 progesterone concentration in blood and tissues, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + NAD(P)H
-
 Mus musculus 4-pregnen-20alpha,21-diol-3-one + NAD(P)+
-
 ?
11-deoxycorticosterone + NAD(P)H
-
 Mus musculus BALB/c 4-pregnen-20alpha,21-diol-3-one + NAD(P)+
-
 ?
17alpha-hydroxyprogesterone + NAD(P)H
-
 Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
17alpha-hydroxyprogesterone + NAD(P)H progesterone catabolism Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
17alpha-hydroxyprogesterone + NAD(P)H
-
 Mus musculus BALB/c 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
17alpha-hydroxyprogesterone + NAD(P)H progesterone catabolism Mus musculus BALB/c 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
additional information pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview Mus musculus ?
-
 ?
additional information pregnancy induces X-zone regression and abolishes 20alphaHSD expression, which is partially restored in animals that are kept from nursing their pups, lactation inhibits enzyme expression, X-zone regulation, overview Mus musculus BALB/c ?
-
 ?

Synonyms

Synonyms Comment Organism
20alpha-HSD
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
 Mus musculus
NAD(P)H
-
 Mus musculus