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show all sequences of 1.1.1.145

Purification and characterization of 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol

Nakajin, S.; Ishii, A.; Shinoda, M.; Biol. Pharm. Bull. 17, 1155-1160 (1994)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
AgNO3
-
Sus scrofa
Cd2+
-
Sus scrofa
Co2+
-
Sus scrofa
Cu2+
-
Sus scrofa
deoxycorticosterone
-
Sus scrofa
Disulfiram
-
Sus scrofa
Hexestrol
-
Sus scrofa
Hg2+
-
Sus scrofa
Ni2+
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Stilbestrol
-
Sus scrofa
testosterone
-
Sus scrofa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0038
-
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
-
Sus scrofa
0.0152
-
prostaglandin E2
-
Sus scrofa
0.0346
-
progesterone
-
Sus scrofa
0.0461
-
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione
-
Sus scrofa
0.0583
-
testosterone
-
Sus scrofa
0.0621
-
13,14-dihydro-15-keto-prostaglandin F2
-
Sus scrofa
0.0703
-
androstenedione
-
Sus scrofa
0.0827
-
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione
-
Sus scrofa
0.114
-
dehydroepiandrosterone
-
Sus scrofa
0.122
-
D-glucose
-
Sus scrofa
0.123
-
5beta-androstane-3,17-dione
-
Sus scrofa
0.13
-
13,14-dihydro-15-keto-prostaglandin F2alpha
-
Sus scrofa
0.137
-
4-Nitroacetophenone
-
Sus scrofa
0.206
-
17-hydroxyprogesterone
-
Sus scrofa
0.217
-
5alpha-pregnane-3,20-dione
-
Sus scrofa
0.231
-
17beta-hydroxy-5beta-androstane-3-one
-
Sus scrofa
0.246
-
5beta-pregnane-3,20-dione
-
Sus scrofa
0.287
-
D-galactose
-
Sus scrofa
0.319
-
4-carboxybenzaldehyde
-
Sus scrofa
0.373
-
prostaglandin E1
-
Sus scrofa
0.465
-
D-glucuronic acid
-
Sus scrofa
0.466
-
hydritantin
-
Sus scrofa
0.467
-
D-xylose
-
Sus scrofa
0.555
-
Camphorquinone
-
Sus scrofa
0.684
-
17beta-hydroxy-5alpha-androstane-3-one
-
Sus scrofa
0.69
-
caprinaldehyde
-
Sus scrofa
0.693
-
menadione
-
Sus scrofa
1.043
-
5alpha-androstane-3,17-dione
-
Sus scrofa
1.07
-
D-glyceraldehyde
-
Sus scrofa
1.663
-
cyclohexanone
-
Sus scrofa
1.966
-
4-Nitrobenzaldehyde
-
Sus scrofa
2.097
-
4-benzylpyridine
-
Sus scrofa
2.366
-
Phenylglyoxal
-
Sus scrofa
2.408
-
9,10-phenanthrenequinone
-
Sus scrofa
2.651
-
methylglyoxal
-
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Sus scrofa
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
28000
-
gel filtration
Sus scrofa
31000
-
1 * 31000, SDS-PAGE
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dehydroepiandrosterone + NAD+
Sus scrofa
-
androst-5-en-3,17-dione + NADH
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
-
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
testis
-
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.0041
-
-
Sus scrofa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH
-
389394
Sus scrofa
3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
-
-
-
?
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione + NADPH
-
389394
Sus scrofa
3beta,11beta,17alpha,21-tetrahydroxy-5alpha-pregnan-20-one + NADP+
-
-
-
?
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH
-
389394
Sus scrofa
3beta,11beta,17alpha,21-tetrahydroxy-5beta-pregnan-20-one + NADP+
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2 + NADPH
-
389394
Sus scrofa
?
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2alpha + NADPH
-
389394
Sus scrofa
?
-
-
-
?
17-hydroxyprogesterone + NADPH
-
389394
Sus scrofa
3beta,17-dihydroxy-4-pregnen-20-one + NADP+
-
-
-
?
17beta-hydroxy-5alpha-androstane-3-one + NADPH
-
389394
Sus scrofa
3beta,17beta-dihydroxy-5alpha-androstane + NADP+
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NADPH
-
389394
Sus scrofa
3beta,17beta-dihydroxy-5beta-androstane + NADP+
-
-
-
?
4-benzylpyridine + NADPH
-
389394
Sus scrofa
?
-
-
-
?
4-carboxybenzaldehyde + NADP+ + H2O
-
389394
Sus scrofa
4-carboxybenzoic acid + NADPH + H+
-
-
-
?
4-nitroacetophenone + NADPH
-
389394
Sus scrofa
1-(4-nitrophenyl)ethanol + NADP+
-
-
-
?
4-nitrobenzaldehyde + NADPH
-
389394
Sus scrofa
4-nitrobenzyl alcohol + NADP+
-
-
-
?
5alpha-androstane-3,17-dione + NADPH
-
389394
Sus scrofa
3beta-hydroxy-5alpha-androstane-17-one + NADP+
-
-
-
?
5alpha-dihydrotestosterone + NADPH
-
389394
Sus scrofa
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
5alpha-pregnane-3,20-dione + NAD(P)H
-
389394
Sus scrofa
5alpha-pregnane-3beta-ol-20-one + NAD(P)+
-
-
-
?
5beta-androstane-3,17-dione + NADPH
-
389394
Sus scrofa
3beta-hydroxy-5beta-androstane-17-one + NADP+
-
-
-
?
5beta-pregnane-3,20-dione + NAD(P)H + H+
-
389394
Sus scrofa
5beta-pregnane-3beta-ol-20-one + NAD(P)+
-
-
-
?
9,10-phenanthrenequinone + NADPH
-
389394
Sus scrofa
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
-
389394
Sus scrofa
? + NADP+
-
-
-
-
androstenedione + NADPH + H+
-
389394
Sus scrofa
3beta-hydroxy-5-androsten-17-one + NADP+
-
-
-
?
camphorquinone + NADPH + H+
-
389394
Sus scrofa
camphorquinol + NADP+
-
-
-
?
caprinaldehyde + NADPH
-
389394
Sus scrofa
?
-
-
-
?
cyclohexanone + NADPH
-
389394
Sus scrofa
cyclohexanol + NADP+
-
-
-
?
D-galactose + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-glucose + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-glucuronic acid + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-glyceraldehyde + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-xylose + NADPH
-
389394
Sus scrofa
?
-
-
-
?
dehydroepiandrosterone + NAD+
-
389394
Sus scrofa
androst-5-en-3,17-dione + NADH
-
-
-
-
dehydroepiandrosterone + NADPH
-
389394
Sus scrofa
3beta-hydroxy-5-androsten-17-one + NADP+
-
-
-
?
hydritantin + NADPH
-
389394
Sus scrofa
?
-
-
-
?
menadione + NADPH
-
389394
Sus scrofa
menadiol + NADP+
-
-
-
?
methylglyoxal + NADPH
-
389394
Sus scrofa
?
-
-
-
?
phenylglyoxal + NADPH
-
389394
Sus scrofa
?
-
-
-
?
progesterone + NADPH
-
389394
Sus scrofa
3beta-hydroxy-4-pregnen-20-one + NADP+
-
-
-
?
prostaglandin E1 + NADPH
-
389394
Sus scrofa
?
-
-
-
?
prostaglandin E2 + NADPH
-
389394
Sus scrofa
?
-
-
-
?
testosterone + NADPH + H+
-
389394
Sus scrofa
3beta,17beta-dihydroxy-4-androsten + NADP+
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 31000, SDS-PAGE
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
testicular cytosol
Sus scrofa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
testicular cytosol
Sus scrofa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
AgNO3
-
Sus scrofa
Cd2+
-
Sus scrofa
Co2+
-
Sus scrofa
Cu2+
-
Sus scrofa
deoxycorticosterone
-
Sus scrofa
Disulfiram
-
Sus scrofa
Hexestrol
-
Sus scrofa
Hg2+
-
Sus scrofa
Ni2+
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Stilbestrol
-
Sus scrofa
testosterone
-
Sus scrofa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0038
-
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
-
Sus scrofa
0.0152
-
prostaglandin E2
-
Sus scrofa
0.0346
-
progesterone
-
Sus scrofa
0.0461
-
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione
-
Sus scrofa
0.0583
-
testosterone
-
Sus scrofa
0.0621
-
13,14-dihydro-15-keto-prostaglandin F2
-
Sus scrofa
0.0703
-
androstenedione
-
Sus scrofa
0.0827
-
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione
-
Sus scrofa
0.114
-
dehydroepiandrosterone
-
Sus scrofa
0.122
-
D-glucose
-
Sus scrofa
0.123
-
5beta-androstane-3,17-dione
-
Sus scrofa
0.13
-
13,14-dihydro-15-keto-prostaglandin F2alpha
-
Sus scrofa
0.137
-
4-Nitroacetophenone
-
Sus scrofa
0.206
-
17-hydroxyprogesterone
-
Sus scrofa
0.217
-
5alpha-pregnane-3,20-dione
-
Sus scrofa
0.231
-
17beta-hydroxy-5beta-androstane-3-one
-
Sus scrofa
0.246
-
5beta-pregnane-3,20-dione
-
Sus scrofa
0.287
-
D-galactose
-
Sus scrofa
0.319
-
4-carboxybenzaldehyde
-
Sus scrofa
0.373
-
prostaglandin E1
-
Sus scrofa
0.465
-
D-glucuronic acid
-
Sus scrofa
0.466
-
hydritantin
-
Sus scrofa
0.467
-
D-xylose
-
Sus scrofa
0.555
-
Camphorquinone
-
Sus scrofa
0.684
-
17beta-hydroxy-5alpha-androstane-3-one
-
Sus scrofa
0.69
-
caprinaldehyde
-
Sus scrofa
0.693
-
menadione
-
Sus scrofa
1.043
-
5alpha-androstane-3,17-dione
-
Sus scrofa
1.07
-
D-glyceraldehyde
-
Sus scrofa
1.663
-
cyclohexanone
-
Sus scrofa
1.966
-
4-Nitrobenzaldehyde
-
Sus scrofa
2.097
-
4-benzylpyridine
-
Sus scrofa
2.366
-
Phenylglyoxal
-
Sus scrofa
2.408
-
9,10-phenanthrenequinone
-
Sus scrofa
2.651
-
methylglyoxal
-
Sus scrofa
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Sus scrofa
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
28000
-
gel filtration
Sus scrofa
31000
-
1 * 31000, SDS-PAGE
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dehydroepiandrosterone + NAD+
Sus scrofa
-
androst-5-en-3,17-dione + NADH
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
testis
-
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.0041
-
-
Sus scrofa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH
-
389394
Sus scrofa
3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
-
-
-
?
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione + NADPH
-
389394
Sus scrofa
3beta,11beta,17alpha,21-tetrahydroxy-5alpha-pregnan-20-one + NADP+
-
-
-
?
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH
-
389394
Sus scrofa
3beta,11beta,17alpha,21-tetrahydroxy-5beta-pregnan-20-one + NADP+
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2 + NADPH
-
389394
Sus scrofa
?
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2alpha + NADPH
-
389394
Sus scrofa
?
-
-
-
?
17-hydroxyprogesterone + NADPH
-
389394
Sus scrofa
3beta,17-dihydroxy-4-pregnen-20-one + NADP+
-
-
-
?
17beta-hydroxy-5alpha-androstane-3-one + NADPH
-
389394
Sus scrofa
3beta,17beta-dihydroxy-5alpha-androstane + NADP+
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NADPH
-
389394
Sus scrofa
3beta,17beta-dihydroxy-5beta-androstane + NADP+
-
-
-
?
4-benzylpyridine + NADPH
-
389394
Sus scrofa
?
-
-
-
?
4-carboxybenzaldehyde + NADP+ + H2O
-
389394
Sus scrofa
4-carboxybenzoic acid + NADPH + H+
-
-
-
?
4-nitroacetophenone + NADPH
-
389394
Sus scrofa
1-(4-nitrophenyl)ethanol + NADP+
-
-
-
?
4-nitrobenzaldehyde + NADPH
-
389394
Sus scrofa
4-nitrobenzyl alcohol + NADP+
-
-
-
?
5alpha-androstane-3,17-dione + NADPH
-
389394
Sus scrofa
3beta-hydroxy-5alpha-androstane-17-one + NADP+
-
-
-
?
5alpha-dihydrotestosterone + NADPH
-
389394
Sus scrofa
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
5alpha-pregnane-3,20-dione + NAD(P)H
-
389394
Sus scrofa
5alpha-pregnane-3beta-ol-20-one + NAD(P)+
-
-
-
?
5beta-androstane-3,17-dione + NADPH
-
389394
Sus scrofa
3beta-hydroxy-5beta-androstane-17-one + NADP+
-
-
-
?
5beta-pregnane-3,20-dione + NAD(P)H + H+
-
389394
Sus scrofa
5beta-pregnane-3beta-ol-20-one + NAD(P)+
-
-
-
?
9,10-phenanthrenequinone + NADPH
-
389394
Sus scrofa
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
-
389394
Sus scrofa
? + NADP+
-
-
-
-
androstenedione + NADPH + H+
-
389394
Sus scrofa
3beta-hydroxy-5-androsten-17-one + NADP+
-
-
-
?
camphorquinone + NADPH + H+
-
389394
Sus scrofa
camphorquinol + NADP+
-
-
-
?
caprinaldehyde + NADPH
-
389394
Sus scrofa
?
-
-
-
?
cyclohexanone + NADPH
-
389394
Sus scrofa
cyclohexanol + NADP+
-
-
-
?
D-galactose + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-glucose + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-glucuronic acid + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-glyceraldehyde + NADPH
-
389394
Sus scrofa
?
-
-
-
?
D-xylose + NADPH
-
389394
Sus scrofa
?
-
-
-
?
dehydroepiandrosterone + NAD+
-
389394
Sus scrofa
androst-5-en-3,17-dione + NADH
-
-
-
-
dehydroepiandrosterone + NADPH
-
389394
Sus scrofa
3beta-hydroxy-5-androsten-17-one + NADP+
-
-
-
?
hydritantin + NADPH
-
389394
Sus scrofa
?
-
-
-
?
menadione + NADPH
-
389394
Sus scrofa
menadiol + NADP+
-
-
-
?
methylglyoxal + NADPH
-
389394
Sus scrofa
?
-
-
-
?
phenylglyoxal + NADPH
-
389394
Sus scrofa
?
-
-
-
?
progesterone + NADPH
-
389394
Sus scrofa
3beta-hydroxy-4-pregnen-20-one + NADP+
-
-
-
?
prostaglandin E1 + NADPH
-
389394
Sus scrofa
?
-
-
-
?
prostaglandin E2 + NADPH
-
389394
Sus scrofa
?
-
-
-
?
testosterone + NADPH + H+
-
389394
Sus scrofa
3beta,17beta-dihydroxy-4-androsten + NADP+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 31000, SDS-PAGE
Sus scrofa
Other publictions for EC 1.1.1.145
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725807
Wojciechowicz
The activity and localization ...
Sus scrofa
J. Reprod. Dev.
59
49-58
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
725511
Prasad
Mitochondrial 3beta-hydroxyste ...
Homo sapiens
J. Biol. Chem.
287
9534-9546
2012
-
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
1
-
-
-
2
-
1
-
-
-
1
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
1
-
-
-
2
-
1
-
-
-
1
1
1
-
-
-
-
-
-
-
725931
Rasmussen
Expression of hepatic 3beta-hy ...
Sus scrofa
Mol. Biol. Rep.
39
7927-32
2012
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
724302
Rajapaksha
Lipid-mediated unfolding of 3b ...
Homo sapiens
Biochemistry
50
11015-11024
2011
-
-
1
-
-
-
1
-
1
-
1
1
-
1
-
-
-
-
1
-
-
-
3
-
1
-
3
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
1
-
-
-
3
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
724518
Thomas
Inhibition of the M. tuberculo ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bioorg. Med. Chem. Lett.
21
2216-2219
2011
-
-
-
-
-
-
20
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
20
-
-
-
-
-
-
-
20
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
725447
Pawlak
Inner mitochondrial translocas ...
Sus scrofa
J. Biol. Chem.
286
39130-39140
2011
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725612
Zhao
Homology modeling and molecula ...
Homo sapiens
J. Comput. Chem.
32
33-42
2011
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725816
Nakamura
Human adrenal cells that expre ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
123
122-126
2011
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725820
Thomas
Selective inhibition of human ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
125
57-65
2011
-
-
1
-
3
-
2
7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
7
-
-
-
-
9
-
-
-
-
2
-
-
5
-
-
4
9
7
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
7
-
-
-
-
-
-
-
-
5
6
713188
Nittono
3?-hydroxy-??-C??-steroid dehy ...
Homo sapiens
Pediatr. Internat.
52
e192-e195
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713329
Ernst
Expression of 3beta-HSD and P5 ...
Digitalis lanata, Digitalis lanata EHRH
Planta Med.
76
923-927
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725813
Thomas
The functions of key residues ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
120
192-199
2010
-
-
1
-
6
-
1
29
-
-
1
-
-
2
-
-
-
-
-
-
-
-
7
-
1
-
-
28
1
-
-
-
4
-
-
-
-
2
-
-
6
-
-
2
4
29
-
-
2
-
-
-
-
-
-
-
-
-
7
-
2
-
-
29
2
-
-
-
-
-
-
-
26
28
698503
Lysiak
Hypoxia-inducible factor-1alph ...
Mus musculus
J. Androl.
30
146-156
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699845
Hu
The (+)- and (-)-gossypols pot ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
115
14-19
2009
-
-
-
-
-
-
4
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
2
-
-
-
4
4
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700182
Thomas
Structural basis for the selec ...
Homo sapiens
Mol. Cell. Endocrinol.
301
174-182
2009
-
-
-
-
-
-
3
2
-
-
1
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
2
-
-
-
1
2
-
2
-
-
-
1
-
-
-
2
3
2
2
-
-
1
-
-
-
-
-
-
3
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
684725
Matsunaga
Characterization of human DHRS ...
Homo sapiens
Arch. Biochem. Biophys.
477
339-347
2008
-
-
-
-
1
-
6
37
1
-
-
-
-
3
-
-
-
-
-
1
-
-
43
-
-
-
-
35
2
-
-
3
-
-
4
-
-
-
3
-
1
-
4
6
-
37
1
-
-
-
-
-
-
-
-
1
-
-
43
-
-
-
-
35
2
-
-
-
-
-
-
-
-
-
687967
Welzel
Carboxyl-terminal mutations in ...
Homo sapiens
J. Clin. Endocrinol. Metab.
93
1418-1425
2008
-
1
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693887
Thomas
Structure/function of the inhi ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
111
66-73
2008
-
-
1
-
2
-
2
-
-
-
1
-
-
1
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
1
8
-
-
-
-
1
1
-
2
-
-
2
8
-
-
-
1
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699111
Parthasarathy
Effects of corticosterone defi ...
Rattus norvegicus
J. Cell. Biochem.
104
1671-1683
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700557
Fernandez Presas
The key steroidogenic enzyme 3 ...
Taenia crassiceps, Taenia crassiceps WFU, Taenia solium
Parasitol. Res.
103
847-852
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681643
Meffre
3beta-Hydroxysteroid dehydroge ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
104
293-300
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684437
Nicolau-Solano
Relationship between carcass w ...
Sus scrofa
Animal
1
1053-1059
2007
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685186
Yang
Rv1106c from Mycobacterium tub ...
Mycobacterium tuberculosis
Biochemistry
46
9058-9067
2007
-
-
1
-
1
-
2
4
1
-
-
-
-
1
-
-
1
1
-
-
-
-
3
-
-
-
-
2
1
-
-
-
2
-
-
-
-
1
-
-
1
-
-
2
2
4
1
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
686588
Knapczyk
The presence of 3beta-hydroxys ...
Sus scrofa
Exp. Clin. Endocrinol. Diabetes
115
411-416
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688664
Kim
Differential expression of 3be ...
Rattus norvegicus
J. Reprod. Dev.
53
465-471
2007
2
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688685
Thomas
Structure/function of human ty ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
107
80-87
2007
-
-
-
-
6
-
-
24
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
24
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
688686
Wang
Human 3beta-hydroxysteroid deh ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
107
88-99
2007
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689697
Herl
Delta5-3beta-hydroxysteroid de ...
Digitalis lanata
Planta Med.
73
704-710
2007
-
-
1
-
-
-
-
8
-
-
1
-
-
1
-
-
1
-
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
8
-
-
1
-
-
-
-
1
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690002
Szoltys
Expression of androgen recepto ...
Rattus norvegicus
Reprod. Fertil. Dev.
19
356-365
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667452
Sun
Characterization of the Rana g ...
Rana grylio iridovirus, Rana grylio iridovirus 9506
Biochem. Biophys. Res. Commun.
351
44-50
2006
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
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Serine 124 completes the Tyr, ...
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Flavonoid inhibition of overex ...
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Qujeq
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The engineered, cytosolic form ...
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389385
Huang
Membrane-bound human 3beta-hyd ...
Homo sapiens
Protein Expr. Purif.
18
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2000
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Suzuki
3beta-Hydroxysteroid dehydroge ...
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2000
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Thomas
Creation of a fully active, cy ...
Homo sapiens
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3
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389390
Wong
Bovine adrenal 3beta-hydroxyst ...
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71
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1999
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389402
Finsterbusch
DELTA5-3beta-Hydroxysteroid de ...
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209
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1
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389384
Abbaszade
Isolation of a new mouse 3beta ...
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389392
Furster
Purification of a 3beta-hydrox ...
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Expression and characterizatio ...
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389391
Cherradi
Characterization of the 3beta- ...
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Endocrinology
134
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389394
Nakajin
Purification and characterizat ...
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1994
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12
35
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38
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12
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1
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38
1
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389397
Sakai
Ovarian 3beta-hydroxysteroid d ...
Oncorhynchus mykiss
FEBS Lett.
350
309-313
1994
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-
1
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389401
Nash
Over-expression of human type ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
50
235-240
1994
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1
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1
4
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3
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389383
Clarke
Enzyme characteristics of two ...
Mus musculus
Endocrinology
132
1971-1976
1993
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1
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8
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2
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1
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5
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5
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4
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389371
Thomas
Affinity labeling of human pla ...
Homo sapiens
Biochemistry
31
5522-5527
1992
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1
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1
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3
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389388
Riley
Immunohistochemical localizati ...
Homo sapiens
J. Clin. Endocrinol.
75
956-961
1992
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2
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2
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389393
Hebert
Kinetic evidence for separate ...
Sus scrofa
J. Steroid Biochem. Mol. Biol.
42
901-910
1992
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1
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1
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4
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389395
Labrie
Structure and tissue-specific ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
41
421-435
1992
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2
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2
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2
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9
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4
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2
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2
2
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2
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9
-
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4
-
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2898
Simard
Characterization of macaque 3b ...
Macaca mulatta
Mol. Cell. Endocrinol.
75
101-110
1991
-
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1
1
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1
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1
1
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389396
Lorence
3beta-Hydroxysteroid dehydroge ...
Rattus norvegicus
Mol. Cell. Endocrinol.
80
21-31
1991
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1
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2
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2
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389399
Perry
Subcellular distribution of 3b ...
Bos taurus, Mus musculus, Rattus norvegicus
Steroids
56
329-336
1991
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5
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3
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3
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3
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389378
Ishii-Ohba
Testicular and adrenal 3beta-h ...
Rattus norvegicus
J. Steroid Biochem.
27
775-779
1987
-
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1
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389379
Ishii-Ohba
Purification and properties of ...
Rattus norvegicus
J. Steroid Biochem.
25
555-560
1986
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1
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1
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2
1
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389369
Hiwatashi
Purification and kinetic prope ...
Bos taurus
J. Biochem.
98
1519-1526
1985
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5
4
1
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1
1
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1
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1
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1
1
1
2
1
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1
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2
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2
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5
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4
1
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1
1
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1
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1
1
1
2
1
-
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1
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-
-
723061
Owen
The degradation of beta-sitost ...
Pseudomonas sp. 10590, Pseudomonas sp.
J. Steroid Biochem.
23
327-332
1985
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2
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389380
Spona
Differences in inhibition by v ...
Comamonas testosteroni, Rattus norvegicus
Endocrinol. Exp.
17
107-118
1983
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6
2
2
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4
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4
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1
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6
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2
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6
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2
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4
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1
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6
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389372
Rabe
Partial characterization of pl ...
Homo sapiens
J. Steroid Biochem.
17
427-433
1982
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7
2
2
1
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1
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2
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2
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2
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1
1
1
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1
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2
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2
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7
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2
2
1
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1
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2
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2
-
1
1
1
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1
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389373
Armstrong
Properties of 5-ene-3beta-hydr ...
Gallus gallus
J. Steroid Biochem.
17
225-230
1982
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5
1
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1
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2
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2
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5
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1
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1
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2
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2
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389370
Shikita
Preparation of highly purified ...
Pseudomonas sp., Pseudomonas sp. TB
Anal. Biochem.
95
286-292
1979
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4
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2
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1
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1
1
8
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1
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1
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1
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1
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4
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1
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1
1
8
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1
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1
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389374
Vincent
Role of thiol group(s) in the ...
Bos taurus
Biochim. Biophys. Acta
525
1-8
1978
2
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3
1
1
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1
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1
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1
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2
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1
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2
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1
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3
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1
1
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1
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1
-
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2
-
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389381
Kerenyi
Properties of delta5-3beta-hyd ...
Streptomyces griseocarneus
Acta Microbiol. Acad. Sci. Hung.
22
487-496
1975
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1
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1
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1
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3
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1
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1
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1
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3
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1
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1
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2884
Ford
Purification and properties of ...
Ovis aries
J. Biol. Chem.
249
1363-1368
1974
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1
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1
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2
1
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1
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1
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1
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1
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2
1
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389376
Cheatum
Purification and properties of ...
Bos taurus
Biochim. Biophys. Acta
122
1-13
1966
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2
1
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6
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1
1
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3
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3
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1
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2
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1
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2
1
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6
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1
1
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389377
Koritz
The conversion of pregnenolone ...
Rattus norvegicus
Biochemistry
3
1098-1102
1964
-
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-
2
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1
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1
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1
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3
-
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2
-
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2
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2
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-
1
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-
1
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3
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