Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Thionicotinamide adenine dinucleotide | 5-33% of the activity with NAD+, depending on substrate | Homo sapiens |
General Stability | Organism |
---|---|
glycerol, 50%, stabilizes | Homo sapiens |
NAD+ stabilizes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arachidonic acid | - |
Homo sapiens | |
Ethacrynic acid | - |
Homo sapiens | |
Prostaglandin B1 | - |
Homo sapiens | |
Prostanoic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
prostaglandin E1 | - |
Homo sapiens | |
0.0048 | - |
prostaglandin E1 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
1 * 42000, SDS-PAGE | Homo sapiens |
51500 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
15-hydroxyprostaglandin + NAD+ | Homo sapiens | physiological inactivation of prostaglandin by catalyzing the first step in catabolism | 15-oxoprostaglandin + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | single displacement mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.75 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, 5 mM potassium phosphate, pH 7.0, 50% glycerol, 1 mM EDTA, 7 months, 10% loss of activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. prostaglandin E1 | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | specific for NAD+ | Homo sapiens | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
15-hydroxyprostaglandin + NAD+ | physiological inactivation of prostaglandin by catalyzing the first step in catabolism | Homo sapiens | 15-oxoprostaglandin + NADH + H+ | - |
? | |
6-ketoprostaglandin F1alpha + NAD+ | - |
Homo sapiens | 6,15-diketoprostaglandin F1alpha + NADH + H+ | - |
? | |
prostaglandin A1 + NAD+ | - |
Homo sapiens | 15-ketoprostaglandin A1 + NADH + H+ | - |
? | |
prostaglandin D1 + NAD+ | very low activity | Homo sapiens | 15-ketoprostaglandin D1 + NADH + H+ | - |
? | |
prostaglandin E1 + NAD+ | - |
Homo sapiens | 15-ketoprostaglandin E1 + NADH + H+ | - |
? | |
prostaglandin F2alpha + NAD+ | specific for NAD+ | Homo sapiens | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? | |
prostaglandin I2 + NAD+ | - |
Homo sapiens | 15-ketoprostaglandin I2 + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 42000, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | acetylpyridine dinucleotide can not replace NAD+ | Homo sapiens | |
NAD+ | specific for NAD+ | Homo sapiens | |
NADH | - |
Homo sapiens | |
thio-NAD+ | 5-33% of activity with NAD+ depending on substrate | Homo sapiens |