Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Thionicotinamide adenine dinucleotide | can replace NAD+ | Homo sapiens | |
Thionicotinamide adenine dinucleotide | 5-33% of the activity with NAD+, depending on substrate | Homo sapiens |
General Stability | Organism |
---|---|
glycerol, 50%, stabilizes | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
1 * 42000, SDS-PAGE | Homo sapiens |
51500 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.765 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, 50% glycerol, 2 months, 8% loss of activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. prostaglandin E1 | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | i.e. 15-ketoprostaglandin E1 | r | |
11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | specific for NAD+ | Homo sapiens | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? | |
prostaglandin A1 + NAD+ | - |
Homo sapiens | 15-ketoprostaglandin A1 + NADH + H+ | - |
? | |
prostaglandin F2alpha + NAD+ | specific for NAD+ | Homo sapiens | 15-ketoprostaglandin F2alpha + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 42000, SDS-PAGE | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | - |
Homo sapiens | |
NAD+ | specific for NAD+ | Homo sapiens | |
NADH | - |
Homo sapiens |