BRENDA - Enzyme Database show
show all sequences of 1.1.1.138

NADPH generation in Aspergillus nidulans: is the mannitol cycle involved?

Singh, M.; Scrutton, N.S.; Scrutton, M.C.; J. Gen. Microbiol. 134, 643-654 (1988)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-mannitol + NADP+
Aspergillus nidulans
-
D-fructose + NADPH + H+
-
Aspergillus nidulans
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aspergillus nidulans
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
mycelium
-
Aspergillus nidulans
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-mannitol + NADP+
-
94714
Aspergillus nidulans
D-fructose + NADPH + H+
-
94714
Aspergillus nidulans
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Aspergillus nidulans
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Aspergillus nidulans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-mannitol + NADP+
Aspergillus nidulans
-
D-fructose + NADPH + H+
-
Aspergillus nidulans
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
mycelium
-
Aspergillus nidulans
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-mannitol + NADP+
-
94714
Aspergillus nidulans
D-fructose + NADPH + H+
-
94714
Aspergillus nidulans
?
Other publictions for EC 1.1.1.138
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Nuess
Crystal structure of the NADP- ...
Cladosporium herbarum
Biochimie
92
985-993
2010
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1
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697942
Metz
The Hypocrea jecorina (syn. Tr ...
Trichoderma reesei, Trichoderma reesei QM9414
FEBS Lett.
583
1309-1313
2009
1
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9
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686764
Bubner
Structure-guided engineering o ...
Pseudomonas fluorescens
FEBS Lett.
582
233-237
2008
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2
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1
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1
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686808
Velez
Mannitol biosynthesis is requi ...
Alternaria alternata, Alternaria alternata A5
FEMS Microbiol. Lett.
285
122-129
2008
1
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1
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4
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685740
Lee
Ca2+ and Cu2+ supplementation ...
Candida magnoliae, Candida magnoliae HH-01
Biotechnol. Lett.
29
291-294
2007
-
1
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2
-
2
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2
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1
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1
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1
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2
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1
1
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2
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1
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686917
Ceccaroli
Identification and characteriz ...
Tuber borchii
Fungal Genet. Biol.
44
965-978
2007
2
-
1
-
-
-
13
5
-
1
2
1
-
3
-
-
1
1
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4
1
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3
1
1
-
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-
2
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2
1
1
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2
-
1
2
-
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13
1
5
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1
2
1
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1
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4
1
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3
1
1
-
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2
-
-
1
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668299
Schneider
Alternaria alternata NADP-depe ...
Alternaria alternata
Clin. Exp. Allergy
36
1513-1524
2006
-
-
1
-
-
-
1
2
-
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1
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7
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1
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1
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1
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669463
Simon-Nobbe
NADP-dependent mannitol dehydr ...
Cladosporium herbarum
J. Biol. Chem.
281
16354-16360
2006
-
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1
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8
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1
2
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6
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1
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3
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1
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1
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1
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1
2
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8
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3
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1
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1
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1
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667280
Sasaki
Lactobacillus reuteri ATCC 536 ...
Lactobacillus reuteri
Appl. Microbiol. Biotechnol.
68
36-41
2005
-
-
1
-
-
-
1
6
-
1
3
1
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6
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1
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2
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2
1
1
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1
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2
1
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2
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1
2
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1
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6
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1
3
1
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1
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2
-
2
1
1
-
1
-
2
1
-
-
-
-
-
-
-
-
670585
Voegele
Possible roles for mannitol an ...
Uromyces viciae-fabae
Plant Physiol.
137
190-198
2005
-
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1
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5
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1
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4
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4
2
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2
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2
1
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2
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1
2
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5
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1
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4
2
-
2
-
-
-
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-
2
1
-
-
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-
-
-
-
-
655118
Saha
Purification and characterizat ...
Lactobacillus intermedius
Biotechnol. Prog.
20
537-542
2004
-
-
-
-
-
-
3
1
-
-
3
-
-
2
-
-
1
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1
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4
1
1
2
1
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2
2
1
2
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1
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2
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3
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1
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3
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1
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1
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4
1
1
2
1
-
2
2
1
1
-
-
-
-
-
-
654271
Lee
Purification and characterizat ...
Candida magnoliae
Appl. Environ. Microbiol.
69
4438-4447
2003
-
-
-
-
-
-
7
8
-
1
2
-
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4
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1
1
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7
-
8
1
2
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2
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4
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7
4
8
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1
2
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1
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7
-
8
1
2
-
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-
2
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-
655114
Lee
Controlling substrate concentr ...
Candida magnoliae
Biotechnol. Prog.
19
768-775
2003
-
1
-
-
-
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2
-
-
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1
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1
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1
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2
1
2
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2
1
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1
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2
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2
1
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1
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1
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2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
655224
Klimacek
Pseudomonas fluorescens mannit ...
Pseudomonas fluorescens
Chem. Biol. Interact.
143-144
559-582
2003
-
-
-
-
-
-
-
-
-
1
-
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2
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1
1
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1
1
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656950
Trail
Purification and characterizat ...
Fusarium graminearum
Phytochemistry
61
791-796
2002
-
-
-
-
-
-
2
6
-
-
2
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1
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1
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1
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3
1
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2
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2
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6
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2
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1
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1
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3
1
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2
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285870
Horer
The crystallographic structure ...
Agaricus bisporus
J. Biol. Chem.
276
27555-27561
2001
-
1
1
1
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-
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-
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2
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1
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1
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2
1
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2
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1
1
2
1
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2
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1
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2
1
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-
285871
Sassoon
Crystallization and preliminar ...
Agaricus bisporus
Acta Crystallogr. Sect. D
57
711-713
2001
-
-
1
1
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2
2
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1
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2
1
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2
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1
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2
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1
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2
1
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-
-
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-
-
-
-
285855
Adachi
Crystalline NADP-dependent D-m ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
Biosci. Biotechnol. Biochem.
63
402-407
1999
-
1
-
1
-
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-
4
-
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1
4
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3
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1
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1
1
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6
1
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2
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2
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1
2
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1
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2
1
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4
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1
4
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1
-
1
1
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6
1
-
-
2
-
2
-
1
-
-
-
-
-
-
-
285854
Stoop
Cloning and characterization o ...
Agaricus bisporus
Appl. Environ. Microbiol.
64
4689-4696
1998
-
-
1
-
-
-
-
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1
1
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3
-
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1
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2
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1
1
1
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1
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1
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1
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2
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1
1
1
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-
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-
-
-
285856
Kulkarni
Mannitol metabolism in Lentinu ...
Lentinula edodes
Appl. Environ. Microbiol.
56
250-253
1990
-
-
-
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94714
Singh
NADPH generation in Aspergillu ...
Aspergillus nidulans
J. Gen. Microbiol.
134
643-654
1988
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1
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285858
Martin
13C Nuclear magnetic resonance ...
Cenococcum graniforme
Plant Physiol.
77
499-502
1985
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-
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3
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1
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285859
Morton
-
Mannitol metabolism in Agaricu ...
Agaricus bisporus
J. Gen. Microbiol.
131
2885-2890
1985
-
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2
5
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2
2
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1
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1
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1
1
1
3
1
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2
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2
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2
-
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2
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5
-
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2
2
-
-
-
1
-
1
1
1
3
1
-
-
-
-
2
-
-
-
-
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-
-
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-
285860
Boutelje
-
Mannitol dehydrogenase from in ...
Penicillium chrysogenum
Eur. J. Appl. Microbiol. Biotechnol.
17
7-12
1983
-
-
-
-
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8
2
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1
2
1
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1
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1
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1
1
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3
1
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1
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1
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1
1
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1
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8
-
2
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1
2
1
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1
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1
1
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3
1
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1
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1
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1
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285861
Niehaus
Purification and characterizat ...
Aspergillus parasiticus
J. Bacteriol.
151
243-250
1982
-
-
-
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7
4
-
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2
1
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2
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1
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2
1
-
11
1
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1
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1
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1
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7
-
4
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2
1
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-
1
-
2
1
-
11
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
81101
Grant
-
Sorbitol metabolism by apple s ...
Laminaria digitata
Phytochemistry
20
1505-1511
1981
-
-
-
-
-
-
-
-
-
1
-
2
-
1
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1
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2
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2
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94717
Hult
The distribution of the NADPH ...
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus, Thermomyces lanuginosus
Arch. Microbiol.
128
253-255
1980
-
-
-
-
-
-
-
-
-
-
-
9
-
9
-
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9
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9
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9
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9
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9
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9
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9
-
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-
-
-
-
-
-
-
-
-
-
-
285864
Clancy
-
Polyol dehydrogenases in the r ...
Melampsora lini
J. Gen. Microbiol.
120
85-88
1980
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
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2
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2
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2
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285865
Ruffner
-
Purification and properties of ...
Agaricus bisporus
Phytochemistry
17
865-868
1978
-
-
-
-
-
-
2
3
-
4
1
2
-
1
-
-
1
-
-
1
1
-
6
-
1
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2
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2
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2
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2
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3
-
4
1
2
-
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1
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1
1
-
6
-
1
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2
-
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-
-
-
-
-
-
-
285869
Hammond
-
Carbohydrate metabolism in Aga ...
Agaricus bisporus
J. Gen. Microbiol.
102
245-248
1977
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
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1
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1
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1
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2
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1
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-
-
-
-
285866
Sasajima
-
Polyol dehydrogenases in the s ...
Gluconobacter oxydans
Agric. Biol. Chem.
32
161-169
1968
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
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1
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1
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
285867
Strobel
Polyol metabolism in Diplodia ...
Diplodia viticola Desm.
Arch. Biochem. Biophys.
109
622-626
1965
-
-
-
-
-
-
1
2
-
-
-
3
-
1
-
-
1
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1
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1
5
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1
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1
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1
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1
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2
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3
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1
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1
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1
5
-
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1
-
-
-
-
-
-
-
-
-
-
-
285868
Edmundowicz
Mannitol dehydrogenase from Ag ...
Agaricus campestris
J. Biol. Chem.
238
3539-3541
1963
-
-
-
-
-
-
-
4
-
-
-
2
-
1
-
-
-
-
-
1
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-
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4
-
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4
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4
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2
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1
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