BRENDA - Enzyme Database show
show all sequences of 1.1.1.138

Identification and characterization of the Tuber borchii D-mannitol dehydrogenase which defines a new subfamily within the polyol-specific medium chain dehydrogenases

Ceccaroli, P.; Saltarelli, R.; Guescini, M.; Polidori, E.; Buffalini, M.; Menotta, M.; Pierleoni, R.; Barbieri, E.; Stocchi, V.; Fungal Genet. Biol. 44, 965-978 (2007)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
EDTA
activates 5% at 5 mM, reduction reaction
Tuber borchii
additional information
the enzyme shows a carbon responsive transcriptional pattern and is up-regulated when mycelia are transferred to a culture medium containing D-mannitol or D-fructose, overview
Tuber borchii
Cloned(Commentary)
Commentary
Organism
DNA and amino acid sequence determination and analysis, the enzyme shows a carbon responsive transcriptional pattern and is up-regulated when mycelia are transferred to a culture medium containing D-mannitol or D-fructose, quantitative expression and phylogenetic analysis
Tuber borchii
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
inhibits 96% at 4 mM, reduction reaction
Tuber borchii
2-mercaptoethanol
inhibits 38% at 25 mM, reduction reaction
Tuber borchii
Ca2+
inhibits 21% at 1 mM, reduction reaction
Tuber borchii
Cu2+
inhibits 81% at 0.005 mM, reduction reaction
Tuber borchii
D-fructose
inhibition patterns, overview
Tuber borchii
D-mannitol
inhibition patterns, overview
Tuber borchii
DTT
inhibits 89% at 0.5 mM, reduction reaction
Tuber borchii
Mg2+
inhibits 19% at 1 mM, reduction reaction
Tuber borchii
Mn2+
inhibits 43% at 1 mM, reduction reaction
Tuber borchii
additional information
no inhibition by GSH, Fe2+, and EDTA
Tuber borchii
NADP+
inhibition patterns, overview
Tuber borchii
NADPH
inhibition patterns, overview
Tuber borchii
Zn2+
inhibits 76% at 0.01 mM, reduction reaction
Tuber borchii
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics, overview
Tuber borchii
0.066
-
NADP+
oxidation reaction, pH 9.0, 37C
Tuber borchii
0.1
-
NADPH
reduction reaction, pH 7.5, 37C
Tuber borchii
47
-
D-fructose
reduction reaction, pH 7.5, 37C
Tuber borchii
600
-
D-mannitol
oxidation reaction, pH 9.0, 37C
Tuber borchii
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
two zinc atoms per subunit
Tuber borchii
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38000
-
4 * 38000, SDS-PAGE, peptide mapping
Tuber borchii
163000
-
gel filtration
Tuber borchii
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-mannitol + NADP+
Tuber borchii
enzyme regulation mode, overview
D-fructose + NADPH + H+
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Tuber borchii
Q1ACW3
plant symbiotic ascomycete fungus, strain MYA-1019
-
Purification (Commentary)
Commentary
Organism
native enzyme from mycelia 368fold by anion exchange chromatography, ultrafiltration, and 2',5'-ADP affinity chromatography
Tuber borchii
Reaction
Reaction
Commentary
Organism
D-mannitol + NADP+ = D-fructose + NADPH + H+
sequential ordered bi bi mechanism
Tuber borchii
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
the fruitbody growing on Pinus pinea roots
Tuber borchii
-
mycelium
-
Tuber borchii
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
350
-
purified native enzyme
Tuber borchii
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-mannitol + NADP+
-
686917
Tuber borchii
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
enzyme regulation mode, overview
686917
Tuber borchii
D-fructose + NADPH + H+
-
-
-
r
additional information
the enzyme has a high preference only for D-fructose and D-mannitol, while D-mannose, D-arabinose, D-ribose, D-glucose, D-galactose, D-xylose, D-sorbose and D-sorbitol show only poor activity
686917
Tuber borchii
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
tetramer
4 * 38000, SDS-PAGE, peptide mapping
Tuber borchii
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
40
both reaction directions
Tuber borchii
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8
reduction reaction
Tuber borchii
9
-
oxidation reaction
Tuber borchii
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
strictly dependent on NADP(H), no activity with NAD(H)
Tuber borchii
NADPH
strictly dependent on NADP(H), no activity with NAD(H)
Tuber borchii
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
substrate/product inhibition patterns, overview
Tuber borchii
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Tuber borchii
2D-PAGE
-
5.8
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
EDTA
activates 5% at 5 mM, reduction reaction
Tuber borchii
additional information
the enzyme shows a carbon responsive transcriptional pattern and is up-regulated when mycelia are transferred to a culture medium containing D-mannitol or D-fructose, overview
Tuber borchii
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA and amino acid sequence determination and analysis, the enzyme shows a carbon responsive transcriptional pattern and is up-regulated when mycelia are transferred to a culture medium containing D-mannitol or D-fructose, quantitative expression and phylogenetic analysis
Tuber borchii
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
strictly dependent on NADP(H), no activity with NAD(H)
Tuber borchii
NADPH
strictly dependent on NADP(H), no activity with NAD(H)
Tuber borchii
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
inhibits 96% at 4 mM, reduction reaction
Tuber borchii
2-mercaptoethanol
inhibits 38% at 25 mM, reduction reaction
Tuber borchii
Ca2+
inhibits 21% at 1 mM, reduction reaction
Tuber borchii
Cu2+
inhibits 81% at 0.005 mM, reduction reaction
Tuber borchii
D-fructose
inhibition patterns, overview
Tuber borchii
D-mannitol
inhibition patterns, overview
Tuber borchii
DTT
inhibits 89% at 0.5 mM, reduction reaction
Tuber borchii
Mg2+
inhibits 19% at 1 mM, reduction reaction
Tuber borchii
Mn2+
inhibits 43% at 1 mM, reduction reaction
Tuber borchii
additional information
no inhibition by GSH, Fe2+, and EDTA
Tuber borchii
NADP+
inhibition patterns, overview
Tuber borchii
NADPH
inhibition patterns, overview
Tuber borchii
Zn2+
inhibits 76% at 0.01 mM, reduction reaction
Tuber borchii
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
additional information
-
additional information
substrate/product inhibition patterns, overview
Tuber borchii
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics, overview
Tuber borchii
0.066
-
NADP+
oxidation reaction, pH 9.0, 37C
Tuber borchii
0.1
-
NADPH
reduction reaction, pH 7.5, 37C
Tuber borchii
47
-
D-fructose
reduction reaction, pH 7.5, 37C
Tuber borchii
600
-
D-mannitol
oxidation reaction, pH 9.0, 37C
Tuber borchii
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
two zinc atoms per subunit
Tuber borchii
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
38000
-
4 * 38000, SDS-PAGE, peptide mapping
Tuber borchii
163000
-
gel filtration
Tuber borchii
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-mannitol + NADP+
Tuber borchii
enzyme regulation mode, overview
D-fructose + NADPH + H+
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme from mycelia 368fold by anion exchange chromatography, ultrafiltration, and 2',5'-ADP affinity chromatography
Tuber borchii
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
the fruitbody growing on Pinus pinea roots
Tuber borchii
-
mycelium
-
Tuber borchii
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
350
-
purified native enzyme
Tuber borchii
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-mannitol + NADP+
-
686917
Tuber borchii
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
enzyme regulation mode, overview
686917
Tuber borchii
D-fructose + NADPH + H+
-
-
-
r
additional information
the enzyme has a high preference only for D-fructose and D-mannitol, while D-mannose, D-arabinose, D-ribose, D-glucose, D-galactose, D-xylose, D-sorbose and D-sorbitol show only poor activity
686917
Tuber borchii
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
tetramer
4 * 38000, SDS-PAGE, peptide mapping
Tuber borchii
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
40
both reaction directions
Tuber borchii
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8
reduction reaction
Tuber borchii
9
-
oxidation reaction
Tuber borchii
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Tuber borchii
2D-PAGE
-
5.8
Other publictions for EC 1.1.1.138
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724481
Nuess
Crystal structure of the NADP- ...
Cladosporium herbarum
Biochimie
92
985-993
2010
-
-
-
1
-
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697942
Metz
The Hypocrea jecorina (syn. Tr ...
Trichoderma reesei, Trichoderma reesei QM9414
FEBS Lett.
583
1309-1313
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686764
Bubner
Structure-guided engineering o ...
Pseudomonas fluorescens
FEBS Lett.
582
233-237
2008
-
-
1
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686808
Velez
Mannitol biosynthesis is requi ...
Alternaria alternata, Alternaria alternata A5
FEMS Microbiol. Lett.
285
122-129
2008
1
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685740
Lee
Ca2+ and Cu2+ supplementation ...
Candida magnoliae, Candida magnoliae HH-01
Biotechnol. Lett.
29
291-294
2007
-
1
-
-
-
-
-
-
-
2
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
686917
Ceccaroli
Identification and characteriz ...
Tuber borchii
Fungal Genet. Biol.
44
965-978
2007
2
-
1
-
-
-
13
5
-
1
2
1
-
3
-
-
1
1
-
4
1
-
3
1
1
-
-
-
2
-
-
2
1
1
-
2
-
1
2
-
-
-
-
13
1
5
-
1
2
1
-
-
-
1
-
4
1
-
3
1
1
-
-
-
2
-
-
1
-
-
-
-
-
-
668299
Schneider
Alternaria alternata NADP-depe ...
Alternaria alternata
Clin. Exp. Allergy
36
1513-1524
2006
-
-
1
-
-
-
1
2
-
-
1
-
-
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
2
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
669463
Simon-Nobbe
NADP-dependent mannitol dehydr ...
Cladosporium herbarum
J. Biol. Chem.
281
16354-16360
2006
-
-
1
-
-
-
-
8
-
-
1
2
-
6
-
-
1
-
-
-
2
-
3
-
1
-
-
-
1
-
-
2
-
1
-
-
-
1
2
-
-
-
-
-
-
8
-
-
1
2
-
-
-
1
-
-
2
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
667280
Sasaki
Lactobacillus reuteri ATCC 536 ...
Lactobacillus reuteri
Appl. Microbiol. Biotechnol.
68
36-41
2005
-
-
1
-
-
-
1
6
-
1
3
1
-
6
-
-
1
-
-
-
2
-
2
1
1
-
1
-
2
1
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
6
-
1
3
1
-
-
-
1
-
-
2
-
2
1
1
-
1
-
2
1
-
-
-
-
-
-
-
-
670585
Voegele
Possible roles for mannitol an ...
Uromyces viciae-fabae
Plant Physiol.
137
190-198
2005
-
-
1
-
-
-
-
5
-
-
-
1
-
4
-
-
-
-
-
4
2
-
2
-
-
-
-
-
2
1
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
5
-
-
-
1
-
-
-
-
-
4
2
-
2
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
655118
Saha
Purification and characterizat ...
Lactobacillus intermedius
Biotechnol. Prog.
20
537-542
2004
-
-
-
-
-
-
3
1
-
-
3
-
-
2
-
-
1
-
-
-
1
-
4
1
1
2
1
-
2
2
1
2
-
1
-
-
-
-
2
-
-
-
-
3
-
1
-
-
3
-
-
-
-
1
-
-
1
-
4
1
1
2
1
-
2
2
1
1
-
-
-
-
-
-
654271
Lee
Purification and characterizat ...
Candida magnoliae
Appl. Environ. Microbiol.
69
4438-4447
2003
-
-
-
-
-
-
7
8
-
1
2
-
-
4
-
-
1
1
-
-
7
-
8
1
2
-
-
-
2
-
-
-
4
-
-
-
-
-
-
-
-
-
-
7
4
8
-
1
2
-
-
-
-
1
-
-
7
-
8
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
655114
Lee
Controlling substrate concentr ...
Candida magnoliae
Biotechnol. Prog.
19
768-775
2003
-
1
-
-
-
-
2
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
2
-
-
-
-
-
-
2
1
-
-
-
1
-
2
-
-
-
-
2
1
-
-
-
1
-
-
-
-
1
-
-
-
-
2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
655224
Klimacek
Pseudomonas fluorescens mannit ...
Pseudomonas fluorescens
Chem. Biol. Interact.
143-144
559-582
2003
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656950
Trail
Purification and characterizat ...
Fusarium graminearum
Phytochemistry
61
791-796
2002
-
-
-
-
-
-
2
6
-
-
2
-
-
1
-
-
1
-
-
-
1
-
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
2
-
-
-
-
1
-
-
1
-
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285870
Horer
The crystallographic structure ...
Agaricus bisporus
J. Biol. Chem.
276
27555-27561
2001
-
1
1
1
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
1
1
2
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285871
Sassoon
Crystallization and preliminar ...
Agaricus bisporus
Acta Crystallogr. Sect. D
57
711-713
2001
-
-
1
1
-
-
-
-
-
-
2
2
-
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285855
Adachi
Crystalline NADP-dependent D-m ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
Biosci. Biotechnol. Biochem.
63
402-407
1999
-
1
-
1
-
-
-
4
-
-
1
4
-
3
-
-
1
-
-
1
1
-
6
1
-
-
2
-
2
-
1
2
-
-
-
-
1
-
2
1
-
-
-
-
-
4
-
-
1
4
-
-
-
1
-
1
1
-
6
1
-
-
2
-
2
-
1
-
-
-
-
-
-
-
285854
Stoop
Cloning and characterization o ...
Agaricus bisporus
Appl. Environ. Microbiol.
64
4689-4696
1998
-
-
1
-
-
-
-
-
-
-
1
1
-
3
-
-
1
-
-
2
-
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
2
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285856
Kulkarni
Mannitol metabolism in Lentinu ...
Lentinula edodes
Appl. Environ. Microbiol.
56
250-253
1990
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
94714
Singh
NADPH generation in Aspergillu ...
Aspergillus nidulans
J. Gen. Microbiol.
134
643-654
1988
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285858
Martin
13C Nuclear magnetic resonance ...
Cenococcum graniforme
Plant Physiol.
77
499-502
1985
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285859
Morton
-
Mannitol metabolism in Agaricu ...
Agaricus bisporus
J. Gen. Microbiol.
131
2885-2890
1985
-
-
-
-
-
-
2
5
-
-
2
2
-
1
-
-
1
-
-
1
1
1
3
1
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
5
-
-
2
2
-
-
-
1
-
1
1
1
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285860
Boutelje
-
Mannitol dehydrogenase from in ...
Penicillium chrysogenum
Eur. J. Appl. Microbiol. Biotechnol.
17
7-12
1983
-
-
-
-
-
-
8
2
-
1
2
1
-
1
-
-
1
-
-
1
1
-
3
1
-
-
1
-
1
-
1
1
-
-
-
-
-
-
1
-
-
-
-
8
-
2
-
1
2
1
-
-
-
1
-
1
1
-
3
1
-
-
1
-
1
-
1
-
-
-
-
-
-
-
285861
Niehaus
Purification and characterizat ...
Aspergillus parasiticus
J. Bacteriol.
151
243-250
1982
-
-
-
-
-
-
7
4
-
-
2
1
-
2
-
-
1
-
-
2
1
-
11
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
7
-
4
-
-
2
1
-
-
-
1
-
2
1
-
11
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
81101
Grant
-
Sorbitol metabolism by apple s ...
Laminaria digitata
Phytochemistry
20
1505-1511
1981
-
-
-
-
-
-
-
-
-
1
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
94717
Hult
The distribution of the NADPH ...
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus, Thermomyces lanuginosus
Arch. Microbiol.
128
253-255
1980
-
-
-
-
-
-
-
-
-
-
-
9
-
9
-
-
-
-
-
9
-
-
9
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
9
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285864
Clancy
-
Polyol dehydrogenases in the r ...
Melampsora lini
J. Gen. Microbiol.
120
85-88
1980
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285865
Ruffner
-
Purification and properties of ...
Agaricus bisporus
Phytochemistry
17
865-868
1978
-
-
-
-
-
-
2
3
-
4
1
2
-
1
-
-
1
-
-
1
1
-
6
-
1
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
3
-
4
1
2
-
-
-
1
-
1
1
-
6
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
285869
Hammond
-
Carbohydrate metabolism in Aga ...
Agaricus bisporus
J. Gen. Microbiol.
102
245-248
1977
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285866
Sasajima
-
Polyol dehydrogenases in the s ...
Gluconobacter oxydans
Agric. Biol. Chem.
32
161-169
1968
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285867
Strobel
Polyol metabolism in Diplodia ...
Diplodia viticola Desm.
Arch. Biochem. Biophys.
109
622-626
1965
-
-
-
-
-
-
1
2
-
-
-
3
-
1
-
-
1
-
-
1
-
1
5
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
3
-
-
-
1
-
1
-
1
5
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
285868
Edmundowicz
Mannitol dehydrogenase from Ag ...
Agaricus campestris
J. Biol. Chem.
238
3539-3541
1963
-
-
-
-
-
-
-
4
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-