BRENDA - Enzyme Database show
show all sequences of 1.1.1.138

NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum

Simon-Nobbe, B.; Denk, U.; Schneider, P.B.; Radauer, C.; Teige, M.; Crameri, R.; Hawranek, T.; Lang, R.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Hartl, A.; Breitenbach, M.; J. Biol. Chem. 281, 16354-16360 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in E. coli; gene MtDH, DNA and amino acid sequence determination and analysis, expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)
Cladosporium herbarum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.053
-
NADP+
pH 7.5, 22°C
Cladosporium herbarum
0.053
-
NADPH
plusminus 0.01 mM, pH 7.5, room temperature
Cladosporium herbarum
0.067
-
NADP+
plusminus 0.007 mM, pH 7.5, room temperature
Cladosporium herbarum
0.067
-
NADPH
pH 7.5, 22°C
Cladosporium herbarum
33
-
D-mannitol
plusminus 5 mM, pH 7.5, room temperature
Cladosporium herbarum
117
-
D-fructose
plusminus 20 mM, pH 7.5, room temperature
Cladosporium herbarum
230
-
D-mannitol
pH 7.5, 22°C
Cladosporium herbarum
1170
-
D-fructose
pH 7.5, 22°C
Cladosporium herbarum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
28320
-
-
Cladosporium herbarum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-mannitol + NADP+
Cladosporium herbarum
-
D-fructose + NADPH + H+
-
-
r
additional information
Cladosporium herbarum
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cladosporium herbarum
P0C0Y5
; i.e. Davidiella tassiana, strain 280202
-
Purification (Commentary)
Commentary
Organism
native enzyme 13.4fold by ammonium sulfate fractionation, hydrophobic interaction chromatography, and anion exchange chromatography; purified by standard chromatographic methods
Cladosporium herbarum
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
allergenic potential on human skin, overview
Cladosporium herbarum
277
-
purified native enzyme
Cladosporium herbarum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-fructose + NADPH + H+
-
669463
Cladosporium herbarum
D-mannitol + NADP+
-
-
-
r
D-mannitol + NADP+
-
669463
Cladosporium herbarum
D-fructose + NADPH + H+
-
-
-
r
additional information
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
669463
Cladosporium herbarum
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
22
-
assay at room temperature, forward reaction
Cladosporium herbarum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at, forward reaction
Cladosporium herbarum
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Cladosporium herbarum
NADPH
-
Cladosporium herbarum
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Cladosporium herbarum
-
-
5.8
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in E. coli; gene MtDH, DNA and amino acid sequence determination and analysis, expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)
Cladosporium herbarum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Cladosporium herbarum
NADPH
-
Cladosporium herbarum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.053
-
NADP+
pH 7.5, 22°C
Cladosporium herbarum
0.053
-
NADPH
plusminus 0.01 mM, pH 7.5, room temperature
Cladosporium herbarum
0.067
-
NADP+
plusminus 0.007 mM, pH 7.5, room temperature
Cladosporium herbarum
0.067
-
NADPH
pH 7.5, 22°C
Cladosporium herbarum
33
-
D-mannitol
plusminus 5 mM, pH 7.5, room temperature
Cladosporium herbarum
117
-
D-fructose
plusminus 20 mM, pH 7.5, room temperature
Cladosporium herbarum
230
-
D-mannitol
pH 7.5, 22°C
Cladosporium herbarum
1170
-
D-fructose
pH 7.5, 22°C
Cladosporium herbarum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
28320
-
-
Cladosporium herbarum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-mannitol + NADP+
Cladosporium herbarum
-
D-fructose + NADPH + H+
-
-
r
additional information
Cladosporium herbarum
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme 13.4fold by ammonium sulfate fractionation, hydrophobic interaction chromatography, and anion exchange chromatography; purified by standard chromatographic methods
Cladosporium herbarum
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
allergenic potential on human skin, overview
Cladosporium herbarum
277
-
purified native enzyme
Cladosporium herbarum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-fructose + NADPH + H+
-
669463
Cladosporium herbarum
D-mannitol + NADP+
-
-
-
r
D-mannitol + NADP+
-
669463
Cladosporium herbarum
D-fructose + NADPH + H+
-
-
-
r
additional information
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
669463
Cladosporium herbarum
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
22
-
assay at room temperature, forward reaction
Cladosporium herbarum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at, forward reaction
Cladosporium herbarum
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Cladosporium herbarum
-
-
5.8
Other publictions for EC 1.1.1.138
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724481
Nuess
Crystal structure of the NADP- ...
Cladosporium herbarum
Biochimie
92
985-993
2010
-
-
-
1
-
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697942
Metz
The Hypocrea jecorina (syn. Tr ...
Trichoderma reesei, Trichoderma reesei QM9414
FEBS Lett.
583
1309-1313
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686764
Bubner
Structure-guided engineering o ...
Pseudomonas fluorescens
FEBS Lett.
582
233-237
2008
-
-
1
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686808
Velez
Mannitol biosynthesis is requi ...
Alternaria alternata, Alternaria alternata A5
FEMS Microbiol. Lett.
285
122-129
2008
1
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685740
Lee
Ca2+ and Cu2+ supplementation ...
Candida magnoliae, Candida magnoliae HH-01
Biotechnol. Lett.
29
291-294
2007
-
1
-
-
-
-
-
-
-
2
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
2
-
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-
-
1
-
2
-
-
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2
-
2
-
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-
1
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
686917
Ceccaroli
Identification and characteriz ...
Tuber borchii
Fungal Genet. Biol.
44
965-978
2007
2
-
1
-
-
-
13
5
-
1
2
1
-
3
-
-
1
1
-
4
1
-
3
1
1
-
-
-
2
-
-
2
1
1
-
2
-
1
2
-
-
-
-
13
1
5
-
1
2
1
-
-
-
1
-
4
1
-
3
1
1
-
-
-
2
-
-
1
-
-
-
-
-
-
668299
Schneider
Alternaria alternata NADP-depe ...
Alternaria alternata
Clin. Exp. Allergy
36
1513-1524
2006
-
-
1
-
-
-
1
2
-
-
1
-
-
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
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1
2
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-
-
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1
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2
-
-
1
-
-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
669463
Simon-Nobbe
NADP-dependent mannitol dehydr ...
Cladosporium herbarum
J. Biol. Chem.
281
16354-16360
2006
-
-
1
-
-
-
-
8
-
-
1
2
-
6
-
-
1
-
-
-
2
-
3
-
1
-
-
-
1
-
-
2
-
1
-
-
-
1
2
-
-
-
-
-
-
8
-
-
1
2
-
-
-
1
-
-
2
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
667280
Sasaki
Lactobacillus reuteri ATCC 536 ...
Lactobacillus reuteri
Appl. Microbiol. Biotechnol.
68
36-41
2005
-
-
1
-
-
-
1
6
-
1
3
1
-
6
-
-
1
-
-
-
2
-
2
1
1
-
1
-
2
1
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
6
-
1
3
1
-
-
-
1
-
-
2
-
2
1
1
-
1
-
2
1
-
-
-
-
-
-
-
-
670585
Voegele
Possible roles for mannitol an ...
Uromyces viciae-fabae
Plant Physiol.
137
190-198
2005
-
-
1
-
-
-
-
5
-
-
-
1
-
4
-
-
-
-
-
4
2
-
2
-
-
-
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-
2
1
-
2
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-
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-
1
2
-
-
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-
5
-
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1
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-
4
2
-
2
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
655118
Saha
Purification and characterizat ...
Lactobacillus intermedius
Biotechnol. Prog.
20
537-542
2004
-
-
-
-
-
-
3
1
-
-
3
-
-
2
-
-
1
-
-
-
1
-
4
1
1
2
1
-
2
2
1
2
-
1
-
-
-
-
2
-
-
-
-
3
-
1
-
-
3
-
-
-
-
1
-
-
1
-
4
1
1
2
1
-
2
2
1
1
-
-
-
-
-
-
654271
Lee
Purification and characterizat ...
Candida magnoliae
Appl. Environ. Microbiol.
69
4438-4447
2003
-
-
-
-
-
-
7
8
-
1
2
-
-
4
-
-
1
1
-
-
7
-
8
1
2
-
-
-
2
-
-
-
4
-
-
-
-
-
-
-
-
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7
4
8
-
1
2
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1
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-
7
-
8
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
655114
Lee
Controlling substrate concentr ...
Candida magnoliae
Biotechnol. Prog.
19
768-775
2003
-
1
-
-
-
-
2
-
-
-
1
-
-
1
-
-
1
-
-
-
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2
1
2
-
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-
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-
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2
1
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1
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2
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2
1
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1
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1
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-
-
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2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
655224
Klimacek
Pseudomonas fluorescens mannit ...
Pseudomonas fluorescens
Chem. Biol. Interact.
143-144
559-582
2003
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
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-
-
-
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1
1
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1
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1
1
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-
-
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-
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-
656950
Trail
Purification and characterizat ...
Fusarium graminearum
Phytochemistry
61
791-796
2002
-
-
-
-
-
-
2
6
-
-
2
-
-
1
-
-
1
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-
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1
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3
1
-
-
-
-
2
-
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-
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2
-
6
-
-
2
-
-
-
-
1
-
-
1
-
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285870
Horer
The crystallographic structure ...
Agaricus bisporus
J. Biol. Chem.
276
27555-27561
2001
-
1
1
1
-
-
-
-
-
-
-
2
-
1
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-
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-
-
1
-
-
2
1
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-
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2
-
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1
1
2
1
-
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2
-
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1
-
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2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285871
Sassoon
Crystallization and preliminar ...
Agaricus bisporus
Acta Crystallogr. Sect. D
57
711-713
2001
-
-
1
1
-
-
-
-
-
-
2
2
-
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
2
2
-
-
-
-
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1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285855
Adachi
Crystalline NADP-dependent D-m ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
Biosci. Biotechnol. Biochem.
63
402-407
1999
-
1
-
1
-
-
-
4
-
-
1
4
-
3
-
-
1
-
-
1
1
-
6
1
-
-
2
-
2
-
1
2
-
-
-
-
1
-
2
1
-
-
-
-
-
4
-
-
1
4
-
-
-
1
-
1
1
-
6
1
-
-
2
-
2
-
1
-
-
-
-
-
-
-
285854
Stoop
Cloning and characterization o ...
Agaricus bisporus
Appl. Environ. Microbiol.
64
4689-4696
1998
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Mannitol metabolism in Lentinu ...
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1990
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NADPH generation in Aspergillu ...
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1988
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285858
Martin
13C Nuclear magnetic resonance ...
Cenococcum graniforme
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1985
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Mannitol metabolism in Agaricu ...
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1985
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285860
Boutelje
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Mannitol dehydrogenase from in ...
Penicillium chrysogenum
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1983
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285861
Niehaus
Purification and characterizat ...
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1982
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Grant
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Sorbitol metabolism by apple s ...
Laminaria digitata
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1981
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94717
Hult
The distribution of the NADPH ...
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus, Thermomyces lanuginosus
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1980
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9
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285864
Clancy
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Polyol dehydrogenases in the r ...
Melampsora lini
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85-88
1980
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285865
Ruffner
-
Purification and properties of ...
Agaricus bisporus
Phytochemistry
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865-868
1978
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6
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Hammond
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Carbohydrate metabolism in Aga ...
Agaricus bisporus
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245-248
1977
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Sasajima
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Polyol dehydrogenases in the s ...
Gluconobacter oxydans
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161-169
1968
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Strobel
Polyol metabolism in Diplodia ...
Diplodia viticola Desm.
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622-626
1965
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285868
Edmundowicz
Mannitol dehydrogenase from Ag ...
Agaricus campestris
J. Biol. Chem.
238
3539-3541
1963
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