BRENDA - Enzyme Database show
show all sequences of 1.1.1.138

Purification and characterization of a novel mannitol dehydrogenase from Lactobacillus intermedius

Saha, B.C.; Biotechnol. Prog. 20, 537-542 (2004)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
EDTA
10 mM, 60% inhibition
Lactobacillus intermedius
additional information
not inhibitory: CaCl2, MgCl2, Cocl2, dithiothreitol
Lactobacillus intermedius
p-chloromercuribenzoate
0.2 mM, complete inhibition
Lactobacillus intermedius
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
20
-
D-fructose
pH 5.5, 30C
Lactobacillus intermedius
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
34500
-
2 * 43000 + 2 * 34500, SDS-PAGE, both subunits have the same amino-terminal amino acid sequence
Lactobacillus intermedius
43000
-
2 * 43000 + 2 * 34500, SDS-PAGE, both subunits have the same amino-terminal amino acid sequence
Lactobacillus intermedius
170000
-
gel filtration
Lactobacillus intermedius
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Lactobacillus intermedius
-
NRRL B-3693, enzyme production depends on growth on fructose or sucrose
-
Purification (Commentary)
Commentary
Organism
-
Lactobacillus intermedius
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
331
-
pH 5.5, 30C
Lactobacillus intermedius
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-fructose + NADPH
-
655118
Lactobacillus intermedius
D-mannitol + NADP+
-
-
-
r
D-mannitol + NAD+
less than 25% of the activity with NADP+
655118
Lactobacillus intermedius
D-fructose + NADH + H+
-
-
-
r
D-mannitol + NADP+
-
655118
Lactobacillus intermedius
D-fructose + NADPH + H+
-
-
-
r
additional information
no substrate: glucose, xylose, arabinose
655118
Lactobacillus intermedius
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
heterotetramer
2 * 43000 + 2 * 34500, SDS-PAGE, both subunits have the same amino-terminal amino acid sequence
Lactobacillus intermedius
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
35
-
reduction of D-fructose
Lactobacillus intermedius
Temperature Range [C]
Temperature Minimum [C]
Temperature Maximum [C]
Commentary
Organism
50
-
reduction of D-fructose, 44% of maximum activity
Lactobacillus intermedius
60
-
reduction of D-fructose, 15% of maximum activity
Lactobacillus intermedius
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
35
-
stable up to
Lactobacillus intermedius
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
reduction of D-fructose
Lactobacillus intermedius
7
-
oxidation of D-fructose
Lactobacillus intermedius
pH Range
pH Minimum
pH Maximum
Commentary
Organism
5
-
reduction of D-fructose, 35% of maximum activity
Lactobacillus intermedius
6.5
-
reduction of D-fructose, 50% of maximum activity
Lactobacillus intermedius
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
4.5
8
-
Lactobacillus intermedius
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Lactobacillus intermedius
NADPH
-
Lactobacillus intermedius
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Lactobacillus intermedius
isoelectric focusing
-
4.9
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Lactobacillus intermedius
NADPH
-
Lactobacillus intermedius
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
EDTA
10 mM, 60% inhibition
Lactobacillus intermedius
additional information
not inhibitory: CaCl2, MgCl2, Cocl2, dithiothreitol
Lactobacillus intermedius
p-chloromercuribenzoate
0.2 mM, complete inhibition
Lactobacillus intermedius
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
20
-
D-fructose
pH 5.5, 30C
Lactobacillus intermedius
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
34500
-
2 * 43000 + 2 * 34500, SDS-PAGE, both subunits have the same amino-terminal amino acid sequence
Lactobacillus intermedius
43000
-
2 * 43000 + 2 * 34500, SDS-PAGE, both subunits have the same amino-terminal amino acid sequence
Lactobacillus intermedius
170000
-
gel filtration
Lactobacillus intermedius
Purification (Commentary) (protein specific)
Commentary
Organism
-
Lactobacillus intermedius
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
331
-
pH 5.5, 30C
Lactobacillus intermedius
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-fructose + NADPH
-
655118
Lactobacillus intermedius
D-mannitol + NADP+
-
-
-
r
D-mannitol + NAD+
less than 25% of the activity with NADP+
655118
Lactobacillus intermedius
D-fructose + NADH + H+
-
-
-
r
D-mannitol + NADP+
-
655118
Lactobacillus intermedius
D-fructose + NADPH + H+
-
-
-
r
additional information
no substrate: glucose, xylose, arabinose
655118
Lactobacillus intermedius
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
heterotetramer
2 * 43000 + 2 * 34500, SDS-PAGE, both subunits have the same amino-terminal amino acid sequence
Lactobacillus intermedius
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
35
-
reduction of D-fructose
Lactobacillus intermedius
Temperature Range [C] (protein specific)
Temperature Minimum [C]
Temperature Maximum [C]
Commentary
Organism
50
-
reduction of D-fructose, 44% of maximum activity
Lactobacillus intermedius
60
-
reduction of D-fructose, 15% of maximum activity
Lactobacillus intermedius
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
35
-
stable up to
Lactobacillus intermedius
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
reduction of D-fructose
Lactobacillus intermedius
7
-
oxidation of D-fructose
Lactobacillus intermedius
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
5
-
reduction of D-fructose, 35% of maximum activity
Lactobacillus intermedius
6.5
-
reduction of D-fructose, 50% of maximum activity
Lactobacillus intermedius
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
4.5
8
-
Lactobacillus intermedius
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Lactobacillus intermedius
isoelectric focusing
-
4.9
Other publictions for EC 1.1.1.138
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724481
Nuess
Crystal structure of the NADP- ...
Cladosporium herbarum
Biochimie
92
985-993
2010
-
-
-
1
-
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697942
Metz
The Hypocrea jecorina (syn. Tr ...
Trichoderma reesei, Trichoderma reesei QM9414
FEBS Lett.
583
1309-1313
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686764
Bubner
Structure-guided engineering o ...
Pseudomonas fluorescens
FEBS Lett.
582
233-237
2008
-
-
1
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
1
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-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686808
Velez
Mannitol biosynthesis is requi ...
Alternaria alternata, Alternaria alternata A5
FEMS Microbiol. Lett.
285
122-129
2008
1
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685740
Lee
Ca2+ and Cu2+ supplementation ...
Candida magnoliae, Candida magnoliae HH-01
Biotechnol. Lett.
29
291-294
2007
-
1
-
-
-
-
-
-
-
2
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
2
-
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-
-
1
-
2
-
-
-
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-
-
-
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
686917
Ceccaroli
Identification and characteriz ...
Tuber borchii
Fungal Genet. Biol.
44
965-978
2007
2
-
1
-
-
-
13
5
-
1
2
1
-
3
-
-
1
1
-
4
1
-
3
1
1
-
-
-
2
-
-
2
1
1
-
2
-
1
2
-
-
-
-
13
1
5
-
1
2
1
-
-
-
1
-
4
1
-
3
1
1
-
-
-
2
-
-
1
-
-
-
-
-
-
668299
Schneider
Alternaria alternata NADP-depe ...
Alternaria alternata
Clin. Exp. Allergy
36
1513-1524
2006
-
-
1
-
-
-
1
2
-
-
1
-
-
7
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
2
-
1
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1
2
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1
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2
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1
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-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
669463
Simon-Nobbe
NADP-dependent mannitol dehydr ...
Cladosporium herbarum
J. Biol. Chem.
281
16354-16360
2006
-
-
1
-
-
-
-
8
-
-
1
2
-
6
-
-
1
-
-
-
2
-
3
-
1
-
-
-
1
-
-
2
-
1
-
-
-
1
2
-
-
-
-
-
-
8
-
-
1
2
-
-
-
1
-
-
2
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
667280
Sasaki
Lactobacillus reuteri ATCC 536 ...
Lactobacillus reuteri
Appl. Microbiol. Biotechnol.
68
36-41
2005
-
-
1
-
-
-
1
6
-
1
3
1
-
6
-
-
1
-
-
-
2
-
2
1
1
-
1
-
2
1
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
6
-
1
3
1
-
-
-
1
-
-
2
-
2
1
1
-
1
-
2
1
-
-
-
-
-
-
-
-
670585
Voegele
Possible roles for mannitol an ...
Uromyces viciae-fabae
Plant Physiol.
137
190-198
2005
-
-
1
-
-
-
-
5
-
-
-
1
-
4
-
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4
2
-
2
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-
2
1
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2
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1
2
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5
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1
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4
2
-
2
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2
1
-
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-
-
-
-
-
655118
Saha
Purification and characterizat ...
Lactobacillus intermedius
Biotechnol. Prog.
20
537-542
2004
-
-
-
-
-
-
3
1
-
-
3
-
-
2
-
-
1
-
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-
1
-
4
1
1
2
1
-
2
2
1
2
-
1
-
-
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2
-
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-
3
-
1
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3
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-
1
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1
-
4
1
1
2
1
-
2
2
1
1
-
-
-
-
-
-
654271
Lee
Purification and characterizat ...
Candida magnoliae
Appl. Environ. Microbiol.
69
4438-4447
2003
-
-
-
-
-
-
7
8
-
1
2
-
-
4
-
-
1
1
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-
7
-
8
1
2
-
-
-
2
-
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4
-
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7
4
8
-
1
2
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1
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-
7
-
8
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
655114
Lee
Controlling substrate concentr ...
Candida magnoliae
Biotechnol. Prog.
19
768-775
2003
-
1
-
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-
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2
-
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1
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1
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1
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2
1
2
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2
1
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1
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2
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2
1
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1
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1
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2
1
2
-
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655224
Klimacek
Pseudomonas fluorescens mannit ...
Pseudomonas fluorescens
Chem. Biol. Interact.
143-144
559-582
2003
-
-
-
-
-
-
-
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-
1
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2
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1
1
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1
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1
1
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656950
Trail
Purification and characterizat ...
Fusarium graminearum
Phytochemistry
61
791-796
2002
-
-
-
-
-
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2
6
-
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2
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1
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1
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1
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3
1
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2
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2
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6
-
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2
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1
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1
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3
1
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2
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285870
Horer
The crystallographic structure ...
Agaricus bisporus
J. Biol. Chem.
276
27555-27561
2001
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1
1
1
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-
-
-
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2
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1
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1
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2
1
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2
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1
1
2
1
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2
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1
-
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2
1
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-
-
-
-
-
-
-
-
-
-
-
-
285871
Sassoon
Crystallization and preliminar ...
Agaricus bisporus
Acta Crystallogr. Sect. D
57
711-713
2001
-
-
1
1
-
-
-
-
-
-
2
2
-
1
-
-
-
-
-
1
-
-
2
1
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2
-
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1
2
1
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2
2
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1
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2
1
-
-
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-
-
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-
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-
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285855
Adachi
Crystalline NADP-dependent D-m ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
Biosci. Biotechnol. Biochem.
63
402-407
1999
-
1
-
1
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-
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4
-
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1
4
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3
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1
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1
1
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6
1
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2
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2
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1
2
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1
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2
1
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4
-
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1
4
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1
-
1
1
-
6
1
-
-
2
-
2
-
1
-
-
-
-
-
-
-
285854
Stoop
Cloning and characterization o ...
Agaricus bisporus
Appl. Environ. Microbiol.
64
4689-4696
1998
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Mannitol metabolism in Lentinu ...
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1990
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1
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94714
Singh
NADPH generation in Aspergillu ...
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1988
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1
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285858
Martin
13C Nuclear magnetic resonance ...
Cenococcum graniforme
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1
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Mannitol metabolism in Agaricu ...
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1985
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3
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5
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1
1
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1
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2
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285860
Boutelje
-
Mannitol dehydrogenase from in ...
Penicillium chrysogenum
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1983
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8
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1
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8
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2
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2
1
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1
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3
1
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285861
Niehaus
Purification and characterizat ...
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1982
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7
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11
1
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1
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1
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1
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7
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4
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2
1
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1
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2
1
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11
1
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1
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81101
Grant
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Sorbitol metabolism by apple s ...
Laminaria digitata
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1981
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2
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2
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94717
Hult
The distribution of the NADPH ...
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus, Thermomyces lanuginosus
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1980
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9
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9
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9
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9
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9
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9
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9
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9
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285864
Clancy
-
Polyol dehydrogenases in the r ...
Melampsora lini
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85-88
1980
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2
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2
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285865
Ruffner
-
Purification and properties of ...
Agaricus bisporus
Phytochemistry
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1978
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2
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1
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6
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1
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2
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2
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1
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1
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1
1
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6
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1
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Hammond
-
Carbohydrate metabolism in Aga ...
Agaricus bisporus
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1977
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1
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285866
Sasajima
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Polyol dehydrogenases in the s ...
Gluconobacter oxydans
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161-169
1968
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1
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Strobel
Polyol metabolism in Diplodia ...
Diplodia viticola Desm.
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1965
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1
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1
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1
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1
5
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1
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285868
Edmundowicz
Mannitol dehydrogenase from Ag ...
Agaricus campestris
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238
3539-3541
1963
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4
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4
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4
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1
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