BRENDA - Enzyme Database show
show all sequences of 1.1.1.136

UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum

Fan, D.F.; John, C.E.; Zalitis, J.; Feingold, D.S.; Arch. Biochem. Biophys. 135, 45-49 (1969)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
NADH
competitive to NAD+
Alcaligenes sp.
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.5
-
UDP-N-acetyl-D-glucosamine
-
Alcaligenes sp.
1.5
-
NAD+
-
Alcaligenes sp.
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UDP-N-acetyl-D-glucosamine + 2 NAD+ + H2O
Alcaligenes sp.
-
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Alcaligenes sp.
-
i.e. Achromobacter georgiopolitanum, wild-type and capsuleless mutant
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
UDP-D-glucose + NADP+
at 10% the rate of UDP-N-acetyl-D-glucosamine and NAD+
285848
Alcaligenes sp.
?
-
-
-
?
UDP-N-acetyl-D-glucosamine + 2 NAD+ + H2O
-
285848
Alcaligenes sp.
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H+
-
-
-
?
UDP-N-acetyl-D-glucosamine + NADP+
at 10% the rate of NAD+
285848
Alcaligenes sp.
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + NADPH
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
glycine buffer
Alcaligenes sp.
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Alcaligenes sp.
NADP+
reduced at 10% the rate of NAD+
Alcaligenes sp.
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Alcaligenes sp.
NADP+
reduced at 10% the rate of NAD+
Alcaligenes sp.
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
NADH
competitive to NAD+
Alcaligenes sp.
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.5
-
UDP-N-acetyl-D-glucosamine
-
Alcaligenes sp.
1.5
-
NAD+
-
Alcaligenes sp.
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UDP-N-acetyl-D-glucosamine + 2 NAD+ + H2O
Alcaligenes sp.
-
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H+
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
UDP-D-glucose + NADP+
at 10% the rate of UDP-N-acetyl-D-glucosamine and NAD+
285848
Alcaligenes sp.
?
-
-
-
?
UDP-N-acetyl-D-glucosamine + 2 NAD+ + H2O
-
285848
Alcaligenes sp.
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H+
-
-
-
?
UDP-N-acetyl-D-glucosamine + NADP+
at 10% the rate of NAD+
285848
Alcaligenes sp.
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + NADPH
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
glycine buffer
Alcaligenes sp.
Other publictions for EC 1.1.1.136
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725107
Wang
Structural and genetic charact ...
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Glycobiology
22
1321-1331
2012
-
-
1
-
-
-
-
2
-
7
2
-
-
4
-
-
-
-
-
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
7
2
-
-
-
-
-
-
-
-
-
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
712456
Gu
Biosynthesis of a new UDP-suga ...
Bacillus cereus, Bacillus cereus subsp. cytotoxis, NVH 391-98
J. Biol. Chem.
285
24825-24833
2010
-
-
1
-
-
-
-
-
-
-
1
-
-
8
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
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1
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4
1
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-
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-
-
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-
667737
Zhang
Vi antigen biosynthesis in Sal ...
Salmonella enterica subsp. enterica serovar Typhi
Biochemistry
45
8163-8173
2006
-
-
1
-
-
-
-
2
-
1
2
1
-
3
-
-
1
-
-
-
1
1
3
1
1
-
-
2
1
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
1
2
1
-
-
-
1
-
-
1
1
3
1
1
-
-
2
1
1
-
-
-
-
-
-
-
-
656241
Miller
Biochemical characterization o ...
Pseudomonas aeruginosa
J. Biol. Chem.
279
37551-37558
2004
2
-
1
-
-
-
-
1
-
1
3
-
-
3
-
-
1
-
-
-
-
1
1
1
1
-
-
-
1
-
-
1
-
2
-
2
-
1
1
-
-
-
-
-
-
1
-
1
3
-
-
-
-
1
-
-
-
1
1
1
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2273
Kawamura
Biosynthesis of UDP-N-acetyl-D ...
Micrococcus luteus
J. Biochem.
98
105-116
1985
1
-
-
-
-
2
3
2
-
-
-
1
-
3
-
-
1
-
-
-
1
1
1
-
-
-
-
-
2
-
-
1
-
-
-
1
-
-
1
-
-
2
-
3
-
2
-
-
-
1
-
-
-
1
-
-
1
1
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
285850
Wheat
Cellular localization of uridi ...
Citrobacter freundii
J. Bacteriol.
127
1032-1035
1976
-
-
-
-
-
-
-
-
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1
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2
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1
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1
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1
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-
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-
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-
-
-
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-
285848
Fan
UDPacetylglucosamine dehydroge ...
Alcaligenes sp.
Arch. Biochem. Biophys.
135
45-49
1969
-
-
-
-
-
-
1
2
-
-
-
1
-
2
-
-
-
-
-
-
-
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3
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1
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2
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2
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1
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2
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1
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3
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1
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