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Literature summary for 1.1.1.12 extracted from

  • Mahmud, A.; Hattori, K.; Hongwen, C.; Kitamoto, N.; Suzuki, T.; Nakamura, K.; Takamizawa, K.
    NAD+-dependent xylitol dehydrogenase (xdhA) and L-arabitol-4-dehydrogenase (ladA) deletion mutants of Aspergillus oryzae for improved xylitol production (2013), Biotechnol. Lett., 35, 769-777.
    View publication on PubMed
Search for more literature for 1.1.1.12

Cloned(Commentary)

Cloned (Comment) Organism
gene ladA Aspergillus oryzae

Protein Variants

Protein Variants Comment Organism
additional information construction of deletion mutants of ladA and ladA-xdhA, to generate mutants with decreased dehydrogenase activities and increased xylitol production. Genomic DNA from Aspergillus oryzae strain KBN616 is used as the template for amplification of the three xdhA and ladA inserts. Activities of xylitol dehydrogenase and xylose reductase in the mutant strains, phenotype, overview Aspergillus oryzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arabinitol + NAD+ Aspergillus oryzae
-
 L-xylulose + NADH + H+
-
 ?
L-arabinitol + NAD+ Aspergillus oryzae KBN616
-
 L-xylulose + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus oryzae Q763T4 and uracil auxotroph derivative strain P4
-
Aspergillus oryzae KBN616 Q763T4 and uracil auxotroph derivative strain P4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arabinitol + NAD+
-
 Aspergillus oryzae L-xylulose + NADH + H+
-
 ?
L-arabinitol + NAD+
-
 Aspergillus oryzae KBN616 L-xylulose + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
L-arabitol dehydrogenase
-
 Aspergillus oryzae
LADA
-
 Aspergillus oryzae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Aspergillus oryzae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Aspergillus oryzae

General Information

General Information Comment Organism
additional information xylitol production of wild-type and mutant strains, overview Aspergillus oryzae