BRENDA - Enzyme Database show
show all sequences of 1.1.1.112

The dehydrogenation of 1-indanol by a soluble oxidoreductase from bovine liver

Billings, R.E.; Sullivan, H.R.; McMahon, R.E.; J. Biol. Chem. 246, 3512-3517 (1971)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
1 mM, 19% inhibition
Bos taurus
2,2'-bipyridine
1 mM, 30% inhibition
Bos taurus
8-hydroxyquinoline
1 mM, 84% inhibition, 0.1 mM, 40% inhibition
Bos taurus
pyrazole
1 mM, 39% inhibition
Bos taurus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate, CM-cellulose, Sephadex G-75, Sephadex G-100
Bos taurus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Bos taurus
-
kidney
-
Bos taurus
-
liver
-
Bos taurus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.74
-
-
Bos taurus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-acenaphthenol + NAD(P)+
195% activity compared to indan-(RS)-1-ol
285762
Bos taurus
1-acenaphthenone + NAD(P)H
-
285762
Bos taurus
?
1-tetralol + NAD(P)+
195% activity compared to indan-(RS)-1-ol
285762
Bos taurus
1-tetralone + NAD(P)H
-
285762
Bos taurus
?
9-fluorenol + NAD(P)+
112% activity compared to indan-(RS)-1-ol
285762
Bos taurus
9-fluorenone + NAD(P)H
-
285762
Bos taurus
?
benzosuberol + NAD(P)+
12% activity compared to indan-(RS)-1-ol
285762
Bos taurus
benzosuberone + NAD(P)H
-
285762
Bos taurus
?
cyclohexen-3-ol + NAD(P)+
103% activity compared to indan-(RS)-1-ol
285762
Bos taurus
cyclohexen-3-one + NAD(P)H
-
285762
Bos taurus
?
indan-(RS)-1-ol + NAD(P)+
-
285762
Bos taurus
indan-1-one + NAD(P)H
100% activity
285762
Bos taurus
?
indan-(S)-1-ol + NAD(P)+
171% activity compared to indan-(RS)-1-ol
285762
Bos taurus
indan-1-one + NAD(P)H
-
-
-
?
trans-acenaphthene-1,2-diol + NAD(P)+
100% activity compared to indan-(RS)-1-ol
285762
Bos taurus
acenaphtene-1,2-dione + NAD(P)H
-
285762
Bos taurus
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
10
cofactor NAD+
Bos taurus
10
10.5
cofactor NADP+
Bos taurus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Bos taurus
NADP+
-
Bos taurus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Bos taurus
NADP+
-
Bos taurus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
1 mM, 19% inhibition
Bos taurus
2,2'-bipyridine
1 mM, 30% inhibition
Bos taurus
8-hydroxyquinoline
1 mM, 84% inhibition, 0.1 mM, 40% inhibition
Bos taurus
pyrazole
1 mM, 39% inhibition
Bos taurus
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate, CM-cellulose, Sephadex G-75, Sephadex G-100
Bos taurus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Bos taurus
-
kidney
-
Bos taurus
-
liver
-
Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.74
-
-
Bos taurus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-acenaphthenol + NAD(P)+
195% activity compared to indan-(RS)-1-ol
285762
Bos taurus
1-acenaphthenone + NAD(P)H
-
285762
Bos taurus
?
1-tetralol + NAD(P)+
195% activity compared to indan-(RS)-1-ol
285762
Bos taurus
1-tetralone + NAD(P)H
-
285762
Bos taurus
?
9-fluorenol + NAD(P)+
112% activity compared to indan-(RS)-1-ol
285762
Bos taurus
9-fluorenone + NAD(P)H
-
285762
Bos taurus
?
benzosuberol + NAD(P)+
12% activity compared to indan-(RS)-1-ol
285762
Bos taurus
benzosuberone + NAD(P)H
-
285762
Bos taurus
?
cyclohexen-3-ol + NAD(P)+
103% activity compared to indan-(RS)-1-ol
285762
Bos taurus
cyclohexen-3-one + NAD(P)H
-
285762
Bos taurus
?
indan-(RS)-1-ol + NAD(P)+
-
285762
Bos taurus
indan-1-one + NAD(P)H
100% activity
285762
Bos taurus
?
indan-(S)-1-ol + NAD(P)+
171% activity compared to indan-(RS)-1-ol
285762
Bos taurus
indan-1-one + NAD(P)H
-
-
-
?
trans-acenaphthene-1,2-diol + NAD(P)+
100% activity compared to indan-(RS)-1-ol
285762
Bos taurus
acenaphtene-1,2-dione + NAD(P)H
-
285762
Bos taurus
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
10
cofactor NAD+
Bos taurus
10
10.5
cofactor NADP+
Bos taurus
Other publictions for EC 1.1.1.112
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
285758
Hara
Monkey liver indanol dehydroge ...
Macaca fuscata
J. Biochem.
106
126-132
1989
-
-
-
-
-
-
8
-
1
-
2
-
-
2
-
-
1
1
-
7
1
1
14
1
-
1
1
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
-
8
-
-
1
-
2
-
-
-
-
1
-
7
1
1
14
1
-
1
1
-
1
-
1
-
-
-
-
-
-
-
285759
Hara
3(20)alpha-hydroxysteroi dehyd ...
Macaca fuscata
J. Biochem.
106
900-903
1989
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
18
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
18
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285760
Hara
Isolation of multiple forms of ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
249
225-236
1986
-
-
-
-
-
-
8
-
1
-
6
-
-
2
-
-
1
-
-
2
7
-
29
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
8
-
-
1
-
6
-
-
-
-
1
-
2
7
-
29
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285761
Kulkarni
Human placental indanol dehydr ...
Homo sapiens
Xenobiotica
15
513-519
1985
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
6
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
6
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285762
Billings
The dehydrogenation of 1-indan ...
Bos taurus
J. Biol. Chem.
246
3512-3517
1971
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
1
-
-
3
1
-
8
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
3
1
-
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-