BRENDA - Enzyme Database show
show all sequences of 1.1.1.112

Isolation of multiple forms of indanol dehydrogenase associated with 17-beta-hydroxysteroid dehydrogenase activity from male rabbit

Hara, A.; Kariya, K.; Nakamura, M.; Nakayama, T.; Saweda, H.; Arch. Biochem. Biophys. 249, 225-236 (1986)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
6alpha-Methylprednisolone
0.1 mM, oxidation of acenaphthenol: 0% inhibition of isozyme 1, 40% inhibition of isozyme 2, 23%,inhibition of isozyme 3, 89% inhibition of isozyme 4, 14% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 18% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 7% inhibition of isozyme 1, 41% inhibition of isozyme 2, 30%,inhibition of isozyme 3, 86% inhibition of isozyme 4, 11% inhibition of isozyme 5, 16% inhibition of isozyme 6 and 20% inhibition of isoenzyme 7
Oryctolagus cuniculus
betamethazone
0.05 mM, oxidation of acenaphthenol: 32% inhibition of isozyme 1, 16% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 95% inhibition of isozyme 4, 27% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 14% inhibition of isozyme 1, 26% inhibition of isozyme 2, 97%,inhibition of isozyme 3, 96% inhibition of isozyme 4, 30% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 6% inhibition of isoenzyme 7
Oryctolagus cuniculus
Dienstrol
0.01 mM, oxidation of acenaphthenol: 27% inhibition of isozyme 1, 84% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 94% inhibition of isozyme 4, 0% inhibition of isozyme 5, 66% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 27% inhibition of isozyme 1, 85% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 97% inhibition of isozyme 4, 0% inhibition of isozyme 5, 51% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7
Oryctolagus cuniculus
diethylstilbestrol
0.01 mM, oxidation of acenaphthenol: 25% inhibition of isozyme 1, 68% inhibition of isozyme 2, 94%,inhibition of isozyme 3, 90% inhibition of isozyme 4, 6% inhibition of isozyme 5, 44% inhibition of isozyme 6 and 44% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 23% inhibition of isozyme 1, 69% inhibition of isozyme 2, 87%,inhibition of isozyme 3, 99% inhibition of isozyme 4, 0% inhibition of isozyme 5, 49% inhibition of isozyme 6 and 47% inhibition of isoenzyme 7
Oryctolagus cuniculus
Flufenamic acid
0.1 mM, oxidation of acenaphthenol: 54% inhibition of isozyme 1, 47% inhibition of isozyme 2, 64%,inhibition of isozyme 3, 60% inhibition of isozyme 4, 50% inhibition of isozyme 5, 57% inhibition of isozyme 6 and 38% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 46% inhibition of isozyme 1, 45% inhibition of isozyme 2, 47%,inhibition of isozyme 3, 49% inhibition of isozyme 4, 58% inhibition of isozyme 5, 46% inhibition of isozyme 6 and 43% inhibition of isoenzyme 7
Oryctolagus cuniculus
Hexestrol
0.01 mM, oxidation of acenaphthenol: 76% inhibition of isozyme 1, 82% inhibition of isozyme 2, 95%,inhibition of isozyme 3, 87% inhibition of isozyme 4, 20% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 72% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 66% inhibition of isozyme 1, 84% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 85% inhibition of isozyme 4, 10% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 77% inhibition of isoenzyme 7
Oryctolagus cuniculus
indomethacin
0.1 mM, oxidation of acenaphthenol: 20% inhibition of isozyme 1, 49% inhibition of isozyme 2, 55%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 64% inhibition of isozyme 5, 59% inhibition of isozyme 6 and 3% inhibition of isoenzyme 7
Oryctolagus cuniculus
Zomepirac
0.1 mM, oxidation of acenaphthenol: 69% inhibition of isozyme 1, 46% inhibition of isozyme 2, 71%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 69% inhibition of isozyme 5, 72% inhibition of isozyme 6 and 56% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 70% inhibition of isozyme 1, 68% inhibition of isozyme 2, 68%,inhibition of isozyme 3, 56% inhibition of isozyme 4, 68% inhibition of isozyme 5, 71% inhibition of isozyme 6 and 66% inhibition of isoenzyme 7
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30000
-
gel filtration, isoenzyme 2
Oryctolagus cuniculus
31000
-
gel filtration, isoenzyme 3; gel filtration, isoenzyme 7
Oryctolagus cuniculus
32000
-
gel filtration, isoenzyme 1
Oryctolagus cuniculus
33000
-
gel filtration, isoenzyme 5
Oryctolagus cuniculus
34000
-
gel filtration, isoenzyme 4
Oryctolagus cuniculus
36000
-
gel filtration, isoenzyme 6
Oryctolagus cuniculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate, CM-Sephadex, Sephadex G-1000, DEAE-Sephacel, Blue-Sepharose, hydroxyapatite, DEAE-Sephacel, isoelectric focusing, CM-Sepharose, isoenzymes 1-7
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
1.13
-
isoenzyme 5, substrate 1-acenaphthenol
Oryctolagus cuniculus
2.02
-
isoenzyme 1, substrate 1-acenaphthenol
Oryctolagus cuniculus
2.93
-
isoenzyme 4, substrate 1-acenaphthenol
Oryctolagus cuniculus
4.03
-
isoenzyme 2, substrate 1-acenaphthenol
Oryctolagus cuniculus
4.09
-
isoenzyme 3, substrate 1-acenaphthenol
Oryctolagus cuniculus
4.33
-
isoenzyme 6, substrate 1-acenaphthenol
Oryctolagus cuniculus
7.77
-
isoenzyme 7, substrate 1-acenaphthenol
Oryctolagus cuniculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,2,3,4-tetrahydro-1-naphthol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
1,2,3,4-tetrahydro-1-naphthone + NAD(P)H
-
285760
Oryctolagus cuniculus
-
1-acenaphthenol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
1-acenaphthenone + NAD(P)H
-
285760
Oryctolagus cuniculus
?
1-acenaphthenol + NAD(P)+
four times higher activity compared to indan-1-ol
285760
Oryctolagus cuniculus
1-acenaphthenone + NAD(P)H
-
285760
Oryctolagus cuniculus
?
19-nortestosterone + NAD(P)+
isoenzymes 3-5
285760
Oryctolagus cuniculus
estr-4-en-3,17-dione + NADH
-
285760
Oryctolagus cuniculus
?
4-benzoylpyridine + NADH
isoenzymes 1,2,3,5,6
285760
Oryctolagus cuniculus
4-(benzyl alcohol)pyridine + NAD+
-
285760
Oryctolagus cuniculus
?
4-nitroacetophenone + NADH
isoenzymes 1,2,3,5
285760
Oryctolagus cuniculus
(1-hydroxyethyl)-4-nitro-benzene + NAD+
-
285760
Oryctolagus cuniculus
?
4-nitrobenzaldehyde + NAD(P)H
isoenzymes 1-7
285760
Oryctolagus cuniculus
4-nitrobenzyl alcohol + NAD(P)+
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3-beta,17beta-diol + NAD+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5alpha-androstan-3beta-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3alpha,17beta-diol + NAD+
isoenzymes 1-6
285760
Oryctolagus cuniculus
5alpha-androstan-3alpha-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3alpha-ol-17-one + NAD+
isoenzymes 4-5
285760
Oryctolagus cuniculus
5alpha-androstan-3,17-dione + NADH + H+
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3alpha-ol-17-one + NADH
isoenzymes 2,3,4,6
285760
Oryctolagus cuniculus
5alpha-androstan-3alpha,17alpha-diol + NAD+
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3beta-ol-17-one + NAD+
isoenzymes 2-3
285760
Oryctolagus cuniculus
5alpha-androstan-3,17-dione + NADH + H+
-
285760
Oryctolagus cuniculus
?
5alpha-dihydrotestosterone + NAD(P)+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5alpha-dihydro-17-oxo-testosterone + NADH
-
285760
Oryctolagus cuniculus
?
5alpha-dihydrotestosterone + NAD+
isoenzymes 1-6
285760
Oryctolagus cuniculus
5alpha-17-oxo-dihydrotestosterone + NADH + H+
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3alpha,17beta-diol + NAD+
isoenzymes 1-7
285760
Oryctolagus cuniculus
5beta-androstan-3alpha-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3alpha-ol-17-one + NAD+
isoenzymes 3-4
285760
Oryctolagus cuniculus
5beta-androstan-3,17-dione + NADH
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3alpha-ol-17-one + NADH
isoenzymes 2,3,4,6,7
285760
Oryctolagus cuniculus
5beta-androstan-3alpha,17alpha-diol + NAD+
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3beta,17beta-diol + NAD+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5alpha-androstan-3beta-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3beta-ol-17-one + NAD+
isoenzyme 5
285760
Oryctolagus cuniculus
5beta-androstan-3,17-dione + NADH
-
285760
Oryctolagus cuniculus
?
5beta-dihydrotestosterone + NAD(P)+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5beta-dihydro-17-oxo-testosterone + NADH
-
285760
Oryctolagus cuniculus
?
5beta-dihydrotestosterone + NAD+
isoenzymes 1-6
285760
Oryctolagus cuniculus
5beta-17-oxo-dihydrotestosterone + NADH + H+
-
285760
Oryctolagus cuniculus
?
benzene dihydrodiol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
o-benzoquinone + NAD(P)H
-
-
-
-
cyclohex-2-en-1-ol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
cyclohex-2-en-1-one + NAD(P)H
-
285760
Oryctolagus cuniculus
?
cyclohexanol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
cyclohexanone + NAD(P)H
-
285760
Oryctolagus cuniculus
?
DL-glyceraldehyde + NADH
isoenzymes 1-6
285760
Oryctolagus cuniculus
glycerol + NAD+
-
285760
Oryctolagus cuniculus
?
indan-(S)-1-ol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
indan-1-one + NAD(P)H
-
285760
Oryctolagus cuniculus
-
indan-2-ol + NAD(P)+
isoenzymes 1,2,3,4,6
285760
Oryctolagus cuniculus
indan-2-one + NAD(P)H
-
-
-
-
pyridine-4-aldehyde + NADH
isoenzymes 1-7
285760
Oryctolagus cuniculus
pyridine-4-alcohol + NAD+
-
285760
Oryctolagus cuniculus
?
testosterone + NAD(P)+
-
285760
Oryctolagus cuniculus
androst-4-ene-3,17-dione + NADH + H+
isoenzymes 3-6
285760
Oryctolagus cuniculus
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
10
isoenzyme 5
Oryctolagus cuniculus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Oryctolagus cuniculus
NADP+
-
Oryctolagus cuniculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Oryctolagus cuniculus
NADP+
-
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
6alpha-Methylprednisolone
0.1 mM, oxidation of acenaphthenol: 0% inhibition of isozyme 1, 40% inhibition of isozyme 2, 23%,inhibition of isozyme 3, 89% inhibition of isozyme 4, 14% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 18% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 7% inhibition of isozyme 1, 41% inhibition of isozyme 2, 30%,inhibition of isozyme 3, 86% inhibition of isozyme 4, 11% inhibition of isozyme 5, 16% inhibition of isozyme 6 and 20% inhibition of isoenzyme 7
Oryctolagus cuniculus
betamethazone
0.05 mM, oxidation of acenaphthenol: 32% inhibition of isozyme 1, 16% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 95% inhibition of isozyme 4, 27% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 14% inhibition of isozyme 1, 26% inhibition of isozyme 2, 97%,inhibition of isozyme 3, 96% inhibition of isozyme 4, 30% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 6% inhibition of isoenzyme 7
Oryctolagus cuniculus
Dienstrol
0.01 mM, oxidation of acenaphthenol: 27% inhibition of isozyme 1, 84% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 94% inhibition of isozyme 4, 0% inhibition of isozyme 5, 66% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 27% inhibition of isozyme 1, 85% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 97% inhibition of isozyme 4, 0% inhibition of isozyme 5, 51% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7
Oryctolagus cuniculus
diethylstilbestrol
0.01 mM, oxidation of acenaphthenol: 25% inhibition of isozyme 1, 68% inhibition of isozyme 2, 94%,inhibition of isozyme 3, 90% inhibition of isozyme 4, 6% inhibition of isozyme 5, 44% inhibition of isozyme 6 and 44% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 23% inhibition of isozyme 1, 69% inhibition of isozyme 2, 87%,inhibition of isozyme 3, 99% inhibition of isozyme 4, 0% inhibition of isozyme 5, 49% inhibition of isozyme 6 and 47% inhibition of isoenzyme 7
Oryctolagus cuniculus
Flufenamic acid
0.1 mM, oxidation of acenaphthenol: 54% inhibition of isozyme 1, 47% inhibition of isozyme 2, 64%,inhibition of isozyme 3, 60% inhibition of isozyme 4, 50% inhibition of isozyme 5, 57% inhibition of isozyme 6 and 38% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 46% inhibition of isozyme 1, 45% inhibition of isozyme 2, 47%,inhibition of isozyme 3, 49% inhibition of isozyme 4, 58% inhibition of isozyme 5, 46% inhibition of isozyme 6 and 43% inhibition of isoenzyme 7
Oryctolagus cuniculus
Hexestrol
0.01 mM, oxidation of acenaphthenol: 76% inhibition of isozyme 1, 82% inhibition of isozyme 2, 95%,inhibition of isozyme 3, 87% inhibition of isozyme 4, 20% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 72% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 66% inhibition of isozyme 1, 84% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 85% inhibition of isozyme 4, 10% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 77% inhibition of isoenzyme 7
Oryctolagus cuniculus
indomethacin
0.1 mM, oxidation of acenaphthenol: 20% inhibition of isozyme 1, 49% inhibition of isozyme 2, 55%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 64% inhibition of isozyme 5, 59% inhibition of isozyme 6 and 3% inhibition of isoenzyme 7
Oryctolagus cuniculus
Zomepirac
0.1 mM, oxidation of acenaphthenol: 69% inhibition of isozyme 1, 46% inhibition of isozyme 2, 71%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 69% inhibition of isozyme 5, 72% inhibition of isozyme 6 and 56% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 70% inhibition of isozyme 1, 68% inhibition of isozyme 2, 68%,inhibition of isozyme 3, 56% inhibition of isozyme 4, 68% inhibition of isozyme 5, 71% inhibition of isozyme 6 and 66% inhibition of isoenzyme 7
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30000
-
gel filtration, isoenzyme 2
Oryctolagus cuniculus
31000
-
gel filtration, isoenzyme 3; gel filtration, isoenzyme 7
Oryctolagus cuniculus
32000
-
gel filtration, isoenzyme 1
Oryctolagus cuniculus
33000
-
gel filtration, isoenzyme 5
Oryctolagus cuniculus
34000
-
gel filtration, isoenzyme 4
Oryctolagus cuniculus
36000
-
gel filtration, isoenzyme 6
Oryctolagus cuniculus
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate, CM-Sephadex, Sephadex G-1000, DEAE-Sephacel, Blue-Sepharose, hydroxyapatite, DEAE-Sephacel, isoelectric focusing, CM-Sepharose, isoenzymes 1-7
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
1.13
-
isoenzyme 5, substrate 1-acenaphthenol
Oryctolagus cuniculus
2.02
-
isoenzyme 1, substrate 1-acenaphthenol
Oryctolagus cuniculus
2.93
-
isoenzyme 4, substrate 1-acenaphthenol
Oryctolagus cuniculus
4.03
-
isoenzyme 2, substrate 1-acenaphthenol
Oryctolagus cuniculus
4.09
-
isoenzyme 3, substrate 1-acenaphthenol
Oryctolagus cuniculus
4.33
-
isoenzyme 6, substrate 1-acenaphthenol
Oryctolagus cuniculus
7.77
-
isoenzyme 7, substrate 1-acenaphthenol
Oryctolagus cuniculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,2,3,4-tetrahydro-1-naphthol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
1,2,3,4-tetrahydro-1-naphthone + NAD(P)H
-
285760
Oryctolagus cuniculus
-
1-acenaphthenol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
1-acenaphthenone + NAD(P)H
-
285760
Oryctolagus cuniculus
?
1-acenaphthenol + NAD(P)+
four times higher activity compared to indan-1-ol
285760
Oryctolagus cuniculus
1-acenaphthenone + NAD(P)H
-
285760
Oryctolagus cuniculus
?
19-nortestosterone + NAD(P)+
isoenzymes 3-5
285760
Oryctolagus cuniculus
estr-4-en-3,17-dione + NADH
-
285760
Oryctolagus cuniculus
?
4-benzoylpyridine + NADH
isoenzymes 1,2,3,5,6
285760
Oryctolagus cuniculus
4-(benzyl alcohol)pyridine + NAD+
-
285760
Oryctolagus cuniculus
?
4-nitroacetophenone + NADH
isoenzymes 1,2,3,5
285760
Oryctolagus cuniculus
(1-hydroxyethyl)-4-nitro-benzene + NAD+
-
285760
Oryctolagus cuniculus
?
4-nitrobenzaldehyde + NAD(P)H
isoenzymes 1-7
285760
Oryctolagus cuniculus
4-nitrobenzyl alcohol + NAD(P)+
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3-beta,17beta-diol + NAD+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5alpha-androstan-3beta-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3alpha,17beta-diol + NAD+
isoenzymes 1-6
285760
Oryctolagus cuniculus
5alpha-androstan-3alpha-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3alpha-ol-17-one + NAD+
isoenzymes 4-5
285760
Oryctolagus cuniculus
5alpha-androstan-3,17-dione + NADH + H+
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3alpha-ol-17-one + NADH
isoenzymes 2,3,4,6
285760
Oryctolagus cuniculus
5alpha-androstan-3alpha,17alpha-diol + NAD+
-
285760
Oryctolagus cuniculus
?
5alpha-androstan-3beta-ol-17-one + NAD+
isoenzymes 2-3
285760
Oryctolagus cuniculus
5alpha-androstan-3,17-dione + NADH + H+
-
285760
Oryctolagus cuniculus
?
5alpha-dihydrotestosterone + NAD(P)+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5alpha-dihydro-17-oxo-testosterone + NADH
-
285760
Oryctolagus cuniculus
?
5alpha-dihydrotestosterone + NAD+
isoenzymes 1-6
285760
Oryctolagus cuniculus
5alpha-17-oxo-dihydrotestosterone + NADH + H+
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3alpha,17beta-diol + NAD+
isoenzymes 1-7
285760
Oryctolagus cuniculus
5beta-androstan-3alpha-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3alpha-ol-17-one + NAD+
isoenzymes 3-4
285760
Oryctolagus cuniculus
5beta-androstan-3,17-dione + NADH
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3alpha-ol-17-one + NADH
isoenzymes 2,3,4,6,7
285760
Oryctolagus cuniculus
5beta-androstan-3alpha,17alpha-diol + NAD+
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3beta,17beta-diol + NAD+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5alpha-androstan-3beta-ol-17-one + NADH
-
285760
Oryctolagus cuniculus
?
5beta-androstan-3beta-ol-17-one + NAD+
isoenzyme 5
285760
Oryctolagus cuniculus
5beta-androstan-3,17-dione + NADH
-
285760
Oryctolagus cuniculus
?
5beta-dihydrotestosterone + NAD(P)+
isoenzymes 2-6
285760
Oryctolagus cuniculus
5beta-dihydro-17-oxo-testosterone + NADH
-
285760
Oryctolagus cuniculus
?
5beta-dihydrotestosterone + NAD+
isoenzymes 1-6
285760
Oryctolagus cuniculus
5beta-17-oxo-dihydrotestosterone + NADH + H+
-
285760
Oryctolagus cuniculus
?
benzene dihydrodiol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
o-benzoquinone + NAD(P)H
-
-
-
-
cyclohex-2-en-1-ol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
cyclohex-2-en-1-one + NAD(P)H
-
285760
Oryctolagus cuniculus
?
cyclohexanol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
cyclohexanone + NAD(P)H
-
285760
Oryctolagus cuniculus
?
DL-glyceraldehyde + NADH
isoenzymes 1-6
285760
Oryctolagus cuniculus
glycerol + NAD+
-
285760
Oryctolagus cuniculus
?
indan-(S)-1-ol + NAD(P)+
isoenzymes 1-7
285760
Oryctolagus cuniculus
indan-1-one + NAD(P)H
-
285760
Oryctolagus cuniculus
-
indan-2-ol + NAD(P)+
isoenzymes 1,2,3,4,6
285760
Oryctolagus cuniculus
indan-2-one + NAD(P)H
-
-
-
-
pyridine-4-aldehyde + NADH
isoenzymes 1-7
285760
Oryctolagus cuniculus
pyridine-4-alcohol + NAD+
-
285760
Oryctolagus cuniculus
?
testosterone + NAD(P)+
-
285760
Oryctolagus cuniculus
androst-4-ene-3,17-dione + NADH + H+
isoenzymes 3-6
285760
Oryctolagus cuniculus
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
10
isoenzyme 5
Oryctolagus cuniculus
Other publictions for EC 1.1.1.112
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
285758
Hara
Monkey liver indanol dehydroge ...
Macaca fuscata
J. Biochem.
106
126-132
1989
-
-
-
-
-
-
8
-
1
-
2
-
-
2
-
-
1
1
-
7
1
1
14
1
-
1
1
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
-
8
-
-
1
-
2
-
-
-
-
1
-
7
1
1
14
1
-
1
1
-
1
-
1
-
-
-
-
-
-
-
285759
Hara
3(20)alpha-hydroxysteroi dehyd ...
Macaca fuscata
J. Biochem.
106
900-903
1989
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
18
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
18
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285760
Hara
Isolation of multiple forms of ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
249
225-236
1986
-
-
-
-
-
-
8
-
1
-
6
-
-
2
-
-
1
-
-
2
7
-
29
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
8
-
-
1
-
6
-
-
-
-
1
-
2
7
-
29
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285761
Kulkarni
Human placental indanol dehydr ...
Homo sapiens
Xenobiotica
15
513-519
1985
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
6
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
6
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285762
Billings
The dehydrogenation of 1-indan ...
Bos taurus
J. Biol. Chem.
246
3512-3517
1971
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
1
-
-
3
1
-
8
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
-
3
1
-
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-