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Literature summary for 1.1.1.11 extracted from
- Identification, purification, and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis (1993), Biochem. Biophys. Res. Commun., 196, 1323-1329.
General Stability
| General Stability | Organism |
|---|---|
| Mg2+ stabilizes | Candida tropicalis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
NAD+ | - |
Candida tropicalis |  |
| 39.8 | - |
D-arabinitol | - |
Candida tropicalis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 1-5 mM increases activity about 50%, also enhances stability | Candida tropicalis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31000 | - |
x * 31000, SDS-PAGE | Candida tropicalis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-arabinitol + NAD+ | Candida tropicalis | - |
D-ribulose + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida tropicalis | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 96 | - |
- |
Candida tropicalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-arabinitol + NAD+ | - |
Candida tropicalis | D-ribulose + NADH + H+ | - |
? | |
| Galactitol + NAD+ | 1.6% activity | Candida tropicalis | ? | - |
? | |
| L-Xylulose + NADH | 3% activity | Candida tropicalis | ? | - |
? | |
| additional information | no activity with D-mannitol | Candida tropicalis | ? | - |
? | |
| Xylitol + NAD+ | 5% activity | Candida tropicalis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 31000, SDS-PAGE | Candida tropicalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
optimal activity, reduction | Candida tropicalis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 10 | 11 | enzyme activity increases with increasing pH, measurements above pH 11.0 not feasible | Candida tropicalis |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9.5 | more labile at increasing pH from 6.0-9.5 | Candida tropicalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Candida tropicalis | |
| NADH | - |
Candida tropicalis | |
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