Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | L-carnitine dehydrogenase, complete inhibition | Agrobacterium sp. | |
Hg2+ | L-carnitine dehydrogenase, complete inhibition | Agrobacterium sp. | |
trimethylamine | L-carnitine dehydrogenase, strong inhibition | Agrobacterium sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
NAD+ | L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites | Agrobacterium sp. | |
0.032 | - |
NADH | L-carnitine dehydrogenase | Agrobacterium sp. | |
0.042 | - |
NAD+ | L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites | Agrobacterium sp. | |
0.14 | - |
NAD+ | - |
Alcaligenes sp. | |
0.29 | - |
L-carnitine | L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites | Agrobacterium sp. | |
0.72 | - |
3-dehydrocarnitine | L-carnitine dehydrogenase | Agrobacterium sp. | |
6.1 | - |
L-carnitine | L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites | Agrobacterium sp. | |
9.3 | - |
L-carnitine | - |
Alcaligenes sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
gel filtration | Alcaligenes sp. |
57000 | - |
2 * 57000, L-carnitine dehydrogenase, SDS-PAGE | Agrobacterium sp. |
114000 | - |
gel filtration, L-carnitine dehydrogenase | Agrobacterium sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | Pseudomonas putida | - |
3-dehydrocarnitine + NADH + H+ | - |
r | |
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | Alcaligenes sp. | - |
3-dehydrocarnitine + NADH + H+ | - |
r | |
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | Agrobacterium sp. | - |
3-dehydrocarnitine + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium sp. | - |
DSM 8888, D-carnitine- and L-carnitine dehydrogenases are induced by D-carnitine and L-carnitine respectively | - |
Alcaligenes sp. | - |
- |
- |
Pseudomonas putida | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DEAE-Sepharose FF, Blue-Sepharose, Superose 12HR, Fractogel TSK Butyl, L-carnitine dehydrogenase | Agrobacterium sp. |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
16.75 | - |
L-carnitine dehydrogenase | Agrobacterium sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | - |
Pseudomonas putida | 3-dehydrocarnitine + NADH + H+ | - |
r | |
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | - |
Alcaligenes sp. | 3-dehydrocarnitine + NADH + H+ | - |
r | |
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | - |
Agrobacterium sp. | 3-dehydrocarnitine + NADH + H+ | - |
r | |
carnitine + NAD+ | - |
Pseudomonas putida | 3-dehydrocarnitine + NADH + H+ | - |
r | |
carnitine + NAD+ | - |
Alcaligenes sp. | 3-dehydrocarnitine + NADH + H+ | - |
r | |
carnitine + NAD+ | - |
Agrobacterium sp. | 3-dehydrocarnitine + NADH + H+ | - |
r | |
carnitine amide + NAD+ | L-carnitine dehydrogenase, weak activity | Agrobacterium sp. | 3-dehydrocarnitine amide + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 57000, L-carnitine dehydrogenase, SDS-PAGE | Agrobacterium sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
L-carnitine dehydrogenase | Agrobacterium sp. |
50 | - |
- |
Alcaligenes sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.6 | 6.5 | L-carnitine dehydrogenase, oxidation of L-carnitine | Agrobacterium sp. |
9 | - |
oxidation of L-carnitine | Alcaligenes sp. |
9.5 | - |
L-carnitine dehydrogenase, oxidation of L-carnitine | Agrobacterium sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas putida | |
NAD+ | - |
Alcaligenes sp. | |
NAD+ | - |
Agrobacterium sp. |