Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75452 | - |
- |
Homo sapiens | Q8IZV5 | - |
- |
Mus musculus | Q8VIJ7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Rdh1 | - |
Mus musculus |
RDH10 | - |
Homo sapiens |
RDH16 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | insulin decreases Rdh10 and Rdh16 mRNA in HepG2 cells incubated in serum-free medium by inhibiting transcription and destabilizing mRNA | down |
Mus musculus | oral gavage with glucose or injection with insulin decreases Rdh1 mRNA 50% or greater in mouse liver | down |
Homo sapiens | removing serum from the medium of the human hepatoma cell line HepG2 increases isoforms Rdh10 and Rdh16 mRNA expression 2-3-fold by 4 h, by increasing transcription and stabilizing mRNA | up |
General Information | Comment | Organism |
---|---|---|
physiological function | energy status regulates all-trans-retinoic acid biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases. Removing serum from the medium of the human hepatoma cell line HepG2 increases isoforms Rdh10 and Rdh16 mRNA expression 2-3-fold by 4 h, by increasing transcription and stabilizing mRNA. Insulin decreases Rdh10 and Rdh16 mRNA in HepG2 cells incubated in serum-free medium by inhibiting transcription and destabilizing mRNA. Insulin action requires PI3K and Akt, which suppress FoxO1 | Homo sapiens |
physiological function | energy status regulates all-trans-retinoic acid biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases. Six hours after re-feeding, isoform Rdh1 expression decreases 80-90% in liver and brown adipose tissue, relative to mice fasted 16 h. All-trans-retinoic acid in the liver is decreased 44% 3 h after reduced Rdh expression. Oral gavage with glucose or injection with insulin decreases Rdh1 mRNA 50% or greater in mouse liver | Mus musculus |