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Literature summary for 1.1.1.105 extracted from

  • Obrochta, K.M.; Krois, C.R.; Campos, B.; Napoli, J.L.
    Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1 (2015), J. Biol. Chem., 290, 7259-7268.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens O75452
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-
Homo sapiens Q8IZV5
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Mus musculus Q8VIJ7
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-

Synonyms

Synonyms Comment Organism
Rdh1
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Mus musculus
RDH10
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Homo sapiens
RDH16
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens insulin decreases Rdh10 and Rdh16 mRNA in HepG2 cells incubated in serum-free medium by inhibiting transcription and destabilizing mRNA down
Mus musculus oral gavage with glucose or injection with insulin decreases Rdh1 mRNA 50% or greater in mouse liver down
Homo sapiens removing serum from the medium of the human hepatoma cell line HepG2 increases isoforms Rdh10 and Rdh16 mRNA expression 2-3-fold by 4 h, by increasing transcription and stabilizing mRNA up

General Information

General Information Comment Organism
physiological function energy status regulates all-trans-retinoic acid biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases. Removing serum from the medium of the human hepatoma cell line HepG2 increases isoforms Rdh10 and Rdh16 mRNA expression 2-3-fold by 4 h, by increasing transcription and stabilizing mRNA. Insulin decreases Rdh10 and Rdh16 mRNA in HepG2 cells incubated in serum-free medium by inhibiting transcription and destabilizing mRNA. Insulin action requires PI3K and Akt, which suppress FoxO1 Homo sapiens
physiological function energy status regulates all-trans-retinoic acid biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases. Six hours after re-feeding, isoform Rdh1 expression decreases 80-90% in liver and brown adipose tissue, relative to mice fasted 16 h. All-trans-retinoic acid in the liver is decreased 44% 3 h after reduced Rdh expression. Oral gavage with glucose or injection with insulin decreases Rdh1 mRNA 50% or greater in mouse liver Mus musculus