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Literature summary for 1.1.1.105 extracted from

  • Adams, M.K.; Belyaeva, O.V.; Wu, L.; Kedishvili, N.Y.
    The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis (2014), J. Biol. Chem., 289, 14868-14880.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
retinoic acid-inducible dehydrogenase reductase 3
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells and Sf9 insect cells Homo sapiens
expression in Sf9 cells, HepG2 and HEK293 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000039
-
all-trans-retinol pH and temperature not specified in the publication Homo sapiens
0.000039
-
all-trans-retinol pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00006
-
11-cis-retinol pH and temperature not specified in the publication Homo sapiens
0.00046
-
all-trans-retinaldehyde pH and temperature not specified in the publication Homo sapiens
0.00046
-
all-trans retinal pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.011
-
NADH pH and temperature not specified in the publication Homo sapiens
0.011
-
NADH pH not specified in the publication, temperature not specified in the publication Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q8IZV5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-cis-retinol + NAD+
-
Homo sapiens ?
-
?
all-trans retinal + NADH + H+
-
Homo sapiens all-trans-retinol + NAD+
-
r
all-trans-retinaldehyde + NADH + H+
-
Homo sapiens all-trans-retinol + NAD+
-
r
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinal + NADH + H+
-
r
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinaldehyde + NADH + H+
-
r
additional information the enzyme is not active with NADP+ or NADPH as cofactors Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
RDH10
-
Homo sapiens
retinol dehydrogenase 10
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the retinol dehydrogenase activity of RDH10 is activated by retinaldehyde reductase DHRS3. In turn, DHRS3 requires the presence of retinol dehydrogenase RDH10 to display its full catalytic activity. Neither RDH10 nor DHRS3 has to be itself catalytically active to activate each other Homo sapiens