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Literature summary for 1.1.1.105 extracted from

  • Chen, C.; Thompson, D.A.; Koutalos, Y.
    Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12 (2012), J. Biol. Chem., 287, 24662-24670.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
photoreceptor outer segment
-
Mus musculus 1750
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ Mus musculus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
?
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ Mus musculus C57BL/6 x 129/Sv
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6 x 129/Sv
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye RDH8 localizes to photoreceptor outer segments Mus musculus
-
retina
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
Mus musculus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
?
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
Mus musculus C57BL/6 x 129/Sv all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
?
additional information no activity with decanal Mus musculus ?
-
?
additional information no activity with decanal Mus musculus C57BL/6 x 129/Sv ?
-
?

Synonyms

Synonyms Comment Organism
RDH8
-
Mus musculus
retinoid dehydrogenase/reductase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus

General Information

General Information Comment Organism
evolution RDHs that catalyze the interconversion of retinal and retinol involved in rhodopsin turnover are members of the family of short chain dehydrogenase/reductases Mus musculus
malfunction outer segments of rods deficient in Rdh8 fail to reduce all-trans-retinal. Following exposure to light, a leak of retinoids from outer to inner segments is detected in rods from both wild-type and knock-out mice. In cells lacking Rdh8 or Rdh12, EC 1.1.1.300, this leak is mainly all-trans-retinal, overview. Retinal reductase activity is lost in RDH12-deficient mutants Mus musculus
physiological function in vertebrate rod cells, retinoid dehydrogenases/reductases are critical for reducing the reactive aldehyde all-trans-retinal that is released by photoactivated rhodopsin, to all-trans-retinol. Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. RDH8 in the outer segment provides most of the activity needed to reduce all-trans-retinal generated by the light response, overview Mus musculus