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Literature summary for 1.1.1.105 extracted from

  • Napoli, J.L.
    Physiological insights into all-trans-retinoic acid biosynthesis (2012), Biochim. Biophys. Acta, 1821, 152-167.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cloning of Rdh7 Rattus norvegicus
expression of His6-tagged RDH10 in Spodoptera frugiperda Sf9 insect cell membranes Mus musculus

Protein Variants

Protein Variants Comment Organism
L3R/L5R/R16Q/R19Q/R21Q RDH1 mutant, deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal, the mutant faces the lumen Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. Modifying RDH with N-ethylmaleimide inhibited holo-CRBP1-supported generation of retinal by 90% Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information possible Michaelis-Menten relationship between RDH10 and holo-CRBP1 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
endoplasmic reticulum membrane cytoplasmic or lumenal facing, RDH1. An N-terminal signaling sequence of 22 residues anchors RDH1 in the endoplasmic reticulum projecting into the cytoplasm Mus musculus 5789
-
microsome 80-94% of all enzyme activity Mus musculus
-
-
microsome 80-94% of all enzyme activity Homo sapiens
-
-
microsome 80-94% of all enzyme activity Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ Mus musculus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ Homo sapiens
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ Rattus norvegicus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
RDH1 activity during purification is maintained only with phosphotidylcholine Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
Mus musculus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
Homo sapiens all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
Rattus norvegicus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ RDH interact with/or recognize holo-CRBP1 Homo sapiens all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ RDH interact with/or recognize holo-CRBP1 Rattus norvegicus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ RDH interact with/or recognize holo-CRBP1, except for RDH10 that does not access holo-CRBP1 as substrate Mus musculus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
ir

Synonyms

Synonyms Comment Organism
DHRS9
-
Mus musculus
DHRS9
-
Homo sapiens
DHRS9
-
Rattus norvegicus
Rdh1
-
Mus musculus
RDH10
-
Mus musculus
RDH10
-
Homo sapiens
RDH10
-
Rattus norvegicus
RDH16
-
Homo sapiens
RDH2
-
Rattus norvegicus
RDH7
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus

General Information

General Information Comment Organism
evolution RDH1, RDH10 and DHRS9 are microsomal members of the SDR gene family Mus musculus
malfunction deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal: i.e. the mutant L3R/L5R/R16Q/R19Q/R21Q faces the lumen Mus musculus
metabolism the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview Mus musculus
metabolism the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview Homo sapiens
metabolism the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview Rattus norvegicus
additional information N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. The membrane context of RDH affects function Mus musculus
physiological function RDH1 contributes to a reconstituted pathway of all-trans-retinal biosynthesis, when expressed in intact cells with each of the three retinal dehydrogenases Mus musculus