BRENDA - Enzyme Database show
show all sequences of 1.1.1.105

Physiological insights into all-trans-retinoic acid biosynthesis

Napoli, J.L.; Biochim. Biophys. Acta 1821, 152-167 (2012)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
cloning of Rdh7
Rattus norvegicus
expression of His6-tagged RDH10 in Spodoptera frugiperda Sf9 insect cell membranes
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
L3R/L5R/R16Q/R19Q/R21Q
RDH1 mutant, deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal, the mutant faces the lumen
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. Modifying RDH with N-ethylmaleimide inhibited holo-CRBP1-supported generation of retinal by 90%
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
possible Michaelis-Menten relationship between RDH10 and holo-CRBP1
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
endoplasmic reticulum membrane
cytoplasmic or lumenal facing, RDH1. An N-terminal signaling sequence of 22 residues anchors RDH1 in the endoplasmic reticulum projecting into the cytoplasm
Mus musculus
5789
-
microsome
80-94% of all enzyme activity
Homo sapiens
-
-
microsome
80-94% of all enzyme activity
Mus musculus
-
-
microsome
80-94% of all enzyme activity
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
Mus musculus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
Homo sapiens
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
Rattus norvegicus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
ir
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
RDH1 activity during purification is maintained only with phosphotidylcholine
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
721724
Mus musculus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
721724
Homo sapiens
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
721724
Rattus norvegicus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
RDH interact with/or recognize holo-CRBP1
721724
Homo sapiens
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
RDH interact with/or recognize holo-CRBP1
721724
Rattus norvegicus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
RDH interact with/or recognize holo-CRBP1, except for RDH10 that does not access holo-CRBP1 as substrate
721724
Mus musculus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus
NAD+
-
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
cloning of Rdh7
Rattus norvegicus
expression of His6-tagged RDH10 in Spodoptera frugiperda Sf9 insect cell membranes
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus
NAD+
-
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
L3R/L5R/R16Q/R19Q/R21Q
RDH1 mutant, deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal, the mutant faces the lumen
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. Modifying RDH with N-ethylmaleimide inhibited holo-CRBP1-supported generation of retinal by 90%
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
possible Michaelis-Menten relationship between RDH10 and holo-CRBP1
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
endoplasmic reticulum membrane
cytoplasmic or lumenal facing, RDH1. An N-terminal signaling sequence of 22 residues anchors RDH1 in the endoplasmic reticulum projecting into the cytoplasm
Mus musculus
5789
-
microsome
80-94% of all enzyme activity
Homo sapiens
-
-
microsome
80-94% of all enzyme activity
Mus musculus
-
-
microsome
80-94% of all enzyme activity
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
Mus musculus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
Homo sapiens
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
Rattus norvegicus
-
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
ir
Purification (Commentary) (protein specific)
Commentary
Organism
RDH1 activity during purification is maintained only with phosphotidylcholine
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
721724
Mus musculus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
721724
Homo sapiens
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
-
721724
Rattus norvegicus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
RDH interact with/or recognize holo-CRBP1
721724
Homo sapiens
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
RDH interact with/or recognize holo-CRBP1
721724
Rattus norvegicus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+
RDH interact with/or recognize holo-CRBP1, except for RDH10 that does not access holo-CRBP1 as substrate
721724
Mus musculus
all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
-
-
-
ir
General Information
General Information
Commentary
Organism
evolution
RDH1, RDH10 and DHRS9 are microsomal members of the SDR gene family
Mus musculus
malfunction
deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal: i.e. the mutant L3R/L5R/R16Q/R19Q/R21Q faces the lumen
Mus musculus
metabolism
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview
Homo sapiens
metabolism
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview
Mus musculus
metabolism
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview
Rattus norvegicus
additional information
N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. The membrane context of RDH affects function
Mus musculus
physiological function
RDH1 contributes to a reconstituted pathway of all-trans-retinal biosynthesis, when expressed in intact cells with each of the three retinal dehydrogenases
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
evolution
RDH1, RDH10 and DHRS9 are microsomal members of the SDR gene family
Mus musculus
malfunction
deleting the positive charges from the C-terminal end of the leader, and inserting two arginine residues near the N-terminus of the signaling sequence causes 95% inversion from cytoplasmic to luminal: i.e. the mutant L3R/L5R/R16Q/R19Q/R21Q faces the lumen
Mus musculus
metabolism
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview
Homo sapiens
metabolism
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview
Mus musculus
metabolism
the enzyme catalyzes the first step in all-trans-retinal biosynthesis, modeling of all-trans-retinal homeostasis, overview
Rattus norvegicus
additional information
N-ethylmaleimide does not affect the catalytic action of RDH1, but interferes with its approach to holo-CRBP1, interrupting retinol transfer. The membrane context of RDH affects function
Mus musculus
physiological function
RDH1 contributes to a reconstituted pathway of all-trans-retinal biosynthesis, when expressed in intact cells with each of the three retinal dehydrogenases
Mus musculus
Other publictions for EC 1.1.1.105
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738036
Adams
Characterization of human shor ...
Homo sapiens
Chem. Biol. Interact.
FEHLT
0000
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1
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1
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737923
Hong
Characterization of alcohol de ...
Kangiella koreensis
Biotechnol. Lett.
37
849-856
2015
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1
1
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738033
Belyaeva
Evolutionary origins of retino ...
Ciona intestinalis, Lytechinus variegatus
Chem. Biol. Interact.
234
135-143
2015
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2
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-
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-
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11
-
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5
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-
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738670
Obrochta
Insulin regulates retinol dehy ...
Homo sapiens, Mus musculus
J. Biol. Chem.
290
7259-7268
2015
-
-
-
-
-
-
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7
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3
2
3
5
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738610
Adams
The retinaldehyde reductase ac ...
Homo sapiens
J. Biol. Chem.
289
14868-14880
2014
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1
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3
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2
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2
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1
1
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721724
Napoli
Physiological insights into al ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biochim. Biophys. Acta
1821
152-167
2012
-
-
2
-
1
-
1
1
6
-
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3
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3
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1
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6
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3
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2
3
-
1
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1
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1
6
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3
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1
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6
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-
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-
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7
7
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722769
Chen
Reduction of all-trans-retinal ...
Mus musculus 129/Sv and C57BL/6, Mus musculus
J. Biol. Chem.
287
24662-24670
2012
-
-
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1
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2
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3
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2
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1
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2
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4
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1
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1
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3
3
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723076
Yu
Investigation of the associati ...
Homo sapiens
J. Zhejiang Univ. Sci. B
11
836-841
2010
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1
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1
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1
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690842
Takahashi
Characterization of key residu ...
Homo sapiens
Biochem. J.
419
113-122
2009
-
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1
-
12
-
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6
1
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1
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1
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1
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1
2
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12
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6
1
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1
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1
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691750
Lee
Biochemical characterization o ...
Homo sapiens
Chem. Biol. Interact.
178
182-187
2009
-
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1
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2
1
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2
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2
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2
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1
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2
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8
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3
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1
3
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2
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1
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2
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2
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1
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2
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8
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697544
Strate
Retinol dehydrogenase 10 is a ...
Xenopus laevis
Development
136
461-472
2009
-
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1
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1
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1
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2
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1
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1
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1
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2
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691705
Pares
Medium- and short-chain dehydr ...
Homo sapiens, Mus musculus, Rattus norvegicus
Cell. Mol. Life Sci.
65
3936-3949
2008
-
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1
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3
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6
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6
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1
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2
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697796
Moradi
Focus on molecules: Retinol de ...
Homo sapiens
Exp. Eye Res.
87
160-161
2008
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1
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1
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1
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1
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7
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1
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1
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1
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1
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7
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1
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686662
Dalfo
Analysis of the NADH-dependent ...
Branchiostoma floridae
FEBS J.
274
3739-3752
2007
-
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1
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4
1
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5
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2
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2
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3
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