Cloned (Comment) | Organism |
---|---|
expression in CHO-K1 cells | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
9-cis-retinol | pH 8, 37°C | Mus musculus | |
0.0026 | - |
all-trans-retinol | pH 8, 37°C | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinol + NAD+ | Mus musculus | RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis | all-trans-retinal + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8VIJ7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | strong mRNA expression | Mus musculus | - |
embryo | the mouse embryo expresses RDH1 as early as 7.0 days post-coitus, and expression is especially intense within the neural tube, gut, and neural crest at embryo day 10.5 | Mus musculus | - |
epididymis | mRNA expression | Mus musculus | - |
eye | mRNA expression | Mus musculus | - |
heart | strong mRNA expression | Mus musculus | - |
kidney | strong mRNA expression | Mus musculus | - |
liver | strong mRNA expression | Mus musculus | - |
lung | mRNA expression | Mus musculus | - |
additional information | RDH1 has widespread and intense mRNA expression in tissues of embryonic and adult mice | Mus musculus | - |
ovary | mRNA expression | Mus musculus | - |
pancreas | strong mRNA expression | Mus musculus | - |
prostate | mRNA expression | Mus musculus | - |
skeletal muscle | strong mRNA expression | Mus musculus | - |
smooth muscle | mRNA expression | Mus musculus | - |
submandibular gland | strong mRNA expression | Mus musculus | - |
testis | strong mRNA expression | Mus musculus | - |
thymus | mRNA expression | Mus musculus | - |
thyroid gland | mRNA expression | Mus musculus | - |
uterus | mRNA expression | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
9-cis-retinol + NAD+ | higher activity with all-trans-retinol versus 9-cis-retinol | Mus musculus | 9-cis-retinal + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis | Mus musculus | all-trans-retinal + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | RDH1 has 811fold higher activity with NAD+ versus NADP+. Higher activity with all-trans-retinol versus 9-cis-retinol. Multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities | Mus musculus | all-trans-retinal + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mRDH1 | multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | pH 7.5: 54% of maximal activity, pH 8: maximal activity | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | RDH1 has 811fold higher activity with NAD+ versus NADP+ | Mus musculus | |
NADP+ | RDH1 has 811fold higher activity with NAD+ versus NADP+ | Mus musculus |