Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.105 extracted from

  • Zhang, M.; Hu, P.; Napoli, J.L.
    Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1 (2004), J. Biol. Chem., 279, 51482-51489.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information mutants lacking amino-terminal 18 or 30 amino acids do not localize to endoplasmic reticulum but to mitochondria instead. Deletion mutant lacking 28 C-terminal amino acids localizes both to microsomal and mitochondrial fractions. Deletion of both 18 N-terminal and 28 C-terminal amino acids leeds to overwhelming detection in mitochondria. Fusion of N-terminal 22 amino acids of enzyme with green fluorescent protein localizes in endoplasmic reticulum. Fusion of N-terminal 18 amino acids of enzyme with green fluorescent protein shows diffuse localization. Fusion of green fluorescent protein with C-terminal 29 amino acids of enzyme shows diffuse cytoplasmic and nuclear localization. Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum facing the cytoplasm, mutants lacking amino-terminal 18 or 30 amino acids do not localize to endoplasmic reticulum but to mitochondria instead. Deletion mutant lacking 28 C-terminal amino acids localizes both to microsomal and mitochondrial fractions. Deletion of both 18 N-terminal and 28 C-terminal amino acids leeds to overwhelming detection in mitochondria. Fusion of N-terminal 22 amino acids of enzyme with green fluorescent protein localizes in endoplasmic reticulum. Fusion of N-terminal 18 amino acids of enzyme with green fluorescent protein shows diffuse localization. Fusion of green fluorescent protein with C-terminal 29 amino acids of enzyme shows diffuse cytoplasmic and nuclear localization Mus musculus 5783
-
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
Mus musculus

Synonyms

Synonyms Comment Organism
Rdh1
-
Mus musculus