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Literature summary for 1.1.1.105 extracted from

  • Karlsson, T.; Vahlquist, A.; Kedishvili, N.; Torma, H.
    13-cis-retinoic acid competitively inhibits 3alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? (2003), Biochem. Biophys. Res. Commun., 303, 273-278.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
13-cis-retinoic acid
-
Homo sapiens
3,4-didehydroretinoic acid
-
Homo sapiens
3,4-didehydroretinol
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme expressed in Sf9 cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-didehydroretinol + NAD+ 60% of the efficiency against all-trans-retinol Homo sapiens 3,4-didehydroretinal + NADH
-
?
5alpha-androstan-3alpha-ol-17-one + NAD+
-
Homo sapiens ? + NADH
-
?
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinal + NADH
-
?
androsterone + NAD+
-
Homo sapiens ? + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00021
-
13-cis-retinoic acid pH 7.3, 37°C, substrate 3alpha-adiol Homo sapiens
0.0011
-
13-cis-retinoic acid pH 7.3, 37°C, substrate androsterone Homo sapiens
0.0022
-
3,4-didehydroretinol pH 7.3, 37°C, substrate 3alpha-adiol Homo sapiens
0.0025
-
3,4-didehydroretinol pH 7.3, 37°C, substrate androsterone Homo sapiens
0.0035
-
3,4-didehydroretinoic acid pH 7.3, 37°C, substrate androsterone Homo sapiens
0.0069
-
3,4-didehydroretinoic acid pH 7.3, 37°C, substrate 3alpha-adiol Homo sapiens