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Literature summary for 1.1.1.105 extracted from

  • Jurukovski, V.; Markova, N.G.; Karaman-Jurukovska, N.; Randolph, R.K.; Su, J.; Napoli, J.L.; Simon, M.
    Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes (1999), Mol. Genet. Metab., 67, 62-73.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
retinol dehydrogenase 4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is expressed predominantly in the differentiating spinous layers and is under positive, feed-forward regulation by retinoic acid ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis epidermal keratinocytes, gene is expressed predominantly in the differentiating spinous layers Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinal + NADH
-
?
additional information the enzyme is expressed predominantly in the differentiating spinous layers and is under positive, feed-forward regulation by retinoic acid Homo sapiens ?
-
?
retinol + NAD+
-
Homo sapiens retinal + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Homo sapiens
NAD+ preferred cofactor Homo sapiens