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Literature summary for 1.1.1.105 extracted from

  • Gough, W.H.; VanOoteghem, S.; Sint, T.; Kedishvili, N.Y.
    cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids (1998), J. Biol. Chem., 273, 19778-19785.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant RoDH-4, expressed in microsomes of Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information all-trans-retinol and 13-cis-retinol inhibit RoDH-4 catalyzed oxidation of androsterone Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated with microsomal membrane Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
13-cis-retinol + NAD+ Homo sapiens RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol 13-cis-retinal + NADH + H+
-
?
all-trans-retinol + NAD+ Homo sapiens RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol all-trans-retinal + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75452
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver mRNA for RoDH-4 is abundant in adult liver, where it is translated into RoDH-4 protein. Significant amounts of RoDH-4 message is detected in fetal liver Homo sapiens
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lung significant amounts of RoDH-4 message is detected in fetal lung Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
13-cis-retinol + NAD+
-
Homo sapiens 13-cis-retinal + NADH + H+
-
?
13-cis-retinol + NAD+ RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol Homo sapiens 13-cis-retinal + NADH + H+
-
?
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinal + NADH + H+
-
?
all-trans-retinol + NAD+ RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol Homo sapiens all-trans-retinal + NADH + H+
-
?
additional information the multifunctional enzyme oxidizes the 3alpha-hydroxysteroids androstane-diol and androsterone to dihydrotestosterone and androstanedione, respectively Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
retinol dehydrogenase 4
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Homo sapiens
RoDH-4
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ NAD+ and NADH are the preferred cofactors Homo sapiens
NADH NAD+ and NADH are the preferred cofactors Homo sapiens