Cloned (Comment) | Organism |
---|---|
recombinant RoDH-4, expressed in microsomes of Sf9 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | all-trans-retinol and 13-cis-retinol inhibit RoDH-4 catalyzed oxidation of androsterone | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | associated with microsomal membrane | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
13-cis-retinol + NAD+ | Homo sapiens | RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol | 13-cis-retinal + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | Homo sapiens | RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol | all-trans-retinal + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75452 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | mRNA for RoDH-4 is abundant in adult liver, where it is translated into RoDH-4 protein. Significant amounts of RoDH-4 message is detected in fetal liver | Homo sapiens | - |
lung | significant amounts of RoDH-4 message is detected in fetal lung | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
13-cis-retinol + NAD+ | - |
Homo sapiens | 13-cis-retinal + NADH + H+ | - |
? | |
13-cis-retinol + NAD+ | RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol | Homo sapiens | 13-cis-retinal + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | - |
Homo sapiens | all-trans-retinal + NADH + H+ | - |
? | |
all-trans-retinol + NAD+ | RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol | Homo sapiens | all-trans-retinal + NADH + H+ | - |
? | |
additional information | the multifunctional enzyme oxidizes the 3alpha-hydroxysteroids androstane-diol and androsterone to dihydrotestosterone and androstanedione, respectively | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
retinol dehydrogenase 4 | - |
Homo sapiens |
RoDH-4 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | NAD+ and NADH are the preferred cofactors | Homo sapiens | |
NADH | NAD+ and NADH are the preferred cofactors | Homo sapiens |