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Literature summary for 1.1.1.105 extracted from

  • Leo, M.A.; Kim., C.I.; Lieber, C.S.
    NAD+-dependent retinol dehydrogenase in liver microsomes (1987), Arch. Biochem. Biophys., 259, 241-249.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Chloral hydrate
-
Rattus norvegicus
additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Peromyscus maniculatus
additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Rattus norvegicus
SKF525A moderately Peromyscus maniculatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition ?
-
?
additional information Peromyscus maniculatus chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition ?
-
?

Organism

Organism UniProt Comment Textmining
Peromyscus maniculatus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Peromyscus maniculatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Rattus norvegicus ?
-
?
additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Peromyscus maniculatus ?
-
?
retinal + NADH
-
Rattus norvegicus retinol + NAD+
-
r
retinal + NADH
-
Peromyscus maniculatus retinol + NAD+
-
r
retinal + NADPH + H+
-
Rattus norvegicus retinol + NADP+
-
?
retinol + NADP+
-
Peromyscus maniculatus retinal + NADPH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Rattus norvegicus
NAD+ cofactor Peromyscus maniculatus
NADH cofactor Rattus norvegicus
NADH cofactor Peromyscus maniculatus
NADP+ cofactor Peromyscus maniculatus
NADPH cofactor Rattus norvegicus
NADPH cofactor Peromyscus maniculatus