BRENDA - Enzyme Database show
show all sequences of 1.1.1.101

Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles

Ballas, L.M.; Bell, R.M.; Biochim. Biophys. Acta 665, 586-595 (1981)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Triton X-100
activation
Rattus norvegicus
General Stability
General Stability
Organism
chymotrypsin inactivates
Rattus norvegicus
trypsin inactivates
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Chymotrypsin
inactivation
Rattus norvegicus
Trypsin
inactivation
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
Charles River CD strain
-
Rattus norvegicus Charles River CD
-
Charles River CD strain
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00158
-
-
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus
1-acyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
acyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus Charles River CD
1-acyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
alkyldihydroxyacetone phosphate + NADPH + H+
-
285686
Rattus norvegicus
1-alkyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
alkyldihydroxyacetone phosphate + NADPH + H+
-
285686
Rattus norvegicus Charles River CD
1-alkyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
hexadecyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus
1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
hexadecyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus Charles River CD
1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
palmitoylglycerone phosphate + NADPH
i.e. palmitoyldihydroxyacetone phosphate
285686
Rattus norvegicus
1-palmitoylglycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
palmitoylglycerone phosphate + NADPH
i.e. palmitoyldihydroxyacetone phosphate
285686
Rattus norvegicus Charles River CD
1-palmitoylglycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Triton X-100
activation
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates
Rattus norvegicus
General Stability (protein specific)
General Stability
Organism
chymotrypsin inactivates
Rattus norvegicus
trypsin inactivates
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Chymotrypsin
inactivation
Rattus norvegicus
Trypsin
inactivation
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00158
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus
1-acyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
acyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus Charles River CD
1-acyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
alkyldihydroxyacetone phosphate + NADPH + H+
-
285686
Rattus norvegicus
1-alkyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
alkyldihydroxyacetone phosphate + NADPH + H+
-
285686
Rattus norvegicus Charles River CD
1-alkyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
hexadecyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus
1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
hexadecyldihydroxyacetone phosphate + NADPH
-
285686
Rattus norvegicus Charles River CD
1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
palmitoylglycerone phosphate + NADPH
i.e. palmitoyldihydroxyacetone phosphate
285686
Rattus norvegicus
1-palmitoylglycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus
?
palmitoylglycerone phosphate + NADPH
i.e. palmitoyldihydroxyacetone phosphate
285686
Rattus norvegicus Charles River CD
1-palmitoylglycerol 3-phosphate + NADP+
-
285686
Rattus norvegicus Charles River CD
?
Other publictions for EC 1.1.1.101
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
285695
Athenstaedt
1-Acyldihydroxyacetone-phospha ...
Saccharomyces cerevisiae
J. Biol. Chem.
275
235-240
2000
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1
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1
1
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1
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2
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1
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1
1
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1
1
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2
-
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-
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285696
Hajra
Induction of the peroxisomal g ...
Mus musculus
J. Biol. Chem.
275
9441-9446
2000
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
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-
-
-
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-
2
-
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1
1
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4
-
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-
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-
-
-
-
-
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-
-
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285694
Athenstaedt
Redundant systems of phosphati ...
Saccharomyces cerevisiae
J. Bacteriol.
181
1458-1463
1999
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
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2
-
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1
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1
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-
1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285693
Minskoff
Regulation of phosphatidic aci ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae tpa1
J. Lipid Res.
35
2254-2262
1994
4
-
-
-
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
-
1
-
8
-
-
-
-
-
-
-
-
1
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285691
Racenis
-
The acyl dihydroxyacetone phos ...
Saccharomyces cerevisiae
J. Bacteriol.
174
5704-5710
1992
-
-
-
-
-
-
4
2
-
-
-
4
-
1
-
-
-
-
-
-
-
2
8
-
1
1
2
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
2
-
-
-
4
-
-
-
-
-
-
-
2
8
-
1
1
2
-
1
-
-
-
-
-
-
-
-
-
285692
Hajra
Acyl/alkyldihydroxyacetone pho ...
Cavia porcellus
Methods Enzymol.
209
402-407
1992
-
-
-
-
-
2
-
4
-
-
2
-
-
1
-
-
1
-
-
1
1
-
4
1
-
-
1
-
1
-
-
2
-
-
-
-
-
-
2
-
-
2
-
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4
-
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2
-
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-
1
-
1
1
-
4
1
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-
1
-
1
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-
-
-
-
-
-
-
-
285690
Datta
Purification and properties of ...
Cavia porcellus
J. Biol. Chem.
265
8268-8274
1990
3
-
-
-
-
5
10
4
1
-
2
2
1
2
-
-
1
-
-
2
1
1
6
2
-
-
-
1
-
-
-
2
-
-
-
3
-
-
2
-
-
5
-
10
-
4
1
-
2
2
1
-
-
1
-
2
1
1
6
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
285689
Webber
Properties of the enzymes cata ...
Homo sapiens
Arch. Biochem. Biophys.
254
611-620
1987
-
-
-
-
-
-
-
2
-
-
-
2
-
3
-
-
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-
-
1
-
-
5
-
-
-
1
-
-
-
-
1
-
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-
-
1
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-
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2
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2
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-
1
-
-
5
-
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1
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-
-
-
-
-
-
-
285688
Ghosh
Subcellular distribution and p ...
Cavia porcellus, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
245
523-530
1986
1
-
-
-
-
6
6
9
2
-
-
6
-
8
-
-
1
-
-
5
2
-
16
-
-
-
1
-
1
1
-
5
-
-
-
1
-
-
5
-
-
6
-
6
-
9
2
-
-
6
-
-
-
1
-
5
2
-
16
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
285687
Opperdoes
Localization of the initial st ...
Trypanosoma brucei
FEBS Lett.
169
35-39
1984
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
-
-
-
4
-
-
-
-
-
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-
1
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-
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-
1
-
-
-
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-
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-
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-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285686
Ballas
Topography of glycerolipid syn ...
Rattus norvegicus, Rattus norvegicus Charles River CD
Biochim. Biophys. Acta
665
586-595
1981
1
-
-
-
-
2
2
-
-
-
-
-
-
5
-
-
-
-
-
1
1
-
8
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
1
1
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285685
Hajra
Subcellular localization of ac ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Biol. Chem.
254
10896-10900
1979
-
-
-
-
-
-
-
-
-
-
-
3
-
162
-
-
-
-
-
1
1
-
11
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
1
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285684
LaBelle
Enzymatic reduction of alkyl a ...
Cavia porcellus, Rattus norvegicus
J. Biol. Chem.
247
5825-5834
1972
2
-
-
-
-
2
-
5
-
-
-
4
-
2
-
-
-
-
-
12
-
-
12
-
-
-
2
-
2
-
-
4
-
-
-
2
-
-
4
-
-
2
-
-
-
5
-
-
-
4
-
-
-
-
-
12
-
-
12
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-