BRENDA - Enzyme Database show
show all sequences of 1.1.1.10

DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans

Son, l.e..T.; Ko, K.M.; Cho, J.H.; Singaravelu, G.; Chatterjee, I.; Choi, T.W.; Song, H.O.; Yu, J.R.; Park, B.J.; Lee, S.K.; Ahnn, J.; FEBS Lett. 585, 1310-1316 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene dhs-21, DNA and amino acid sequence determination and analysis, the dhs-21 gene is physically mapped to the cosmid R11D1 between the sma-1 and mes-4genes on chromosome V, expression of His6-tagged enzyme. Spatial and temporal expression pattern of the DHS-21-GFP construct in transgenic worms, overview
Caenorhabditis elegans
Engineering
Amino acid exchange
Commentary
Organism
additional information
library screening and isolation of a dhs-21 deletion mutant
Caenorhabditis elegans
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.17
-
L-erythrulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.18
-
L-ribulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.27
-
D-erythrose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.66
-
L-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.68
-
D-threose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
2.58
-
D-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
of spermatids
Caenorhabditis elegans
5886
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-xylulose + NADPH + H+
Caenorhabditis elegans
-
xylitol + NADP+
-
-
ir
additional information
Caenorhabditis elegans
dicarbonyl/L-xylulose reductase is bifunctional
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Caenorhabditis elegans
Q21929
gene dhs-21
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
gonadal sheath cell
-
Caenorhabditis elegans
-
intestine
-
Caenorhabditis elegans
-
spermathecal-uterine valve
-
Caenorhabditis elegans
-
spermatid
-
Caenorhabditis elegans
-
uterine seam cell
-
Caenorhabditis elegans
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-erythrose + NADPH + H+
-
722271
Caenorhabditis elegans
? + NADP+
-
-
-
ir
D-threose + NADPH + H+
-
722271
Caenorhabditis elegans
? + NADP+
-
-
-
ir
D-xylulose + NADPH + H+
-
722271
Caenorhabditis elegans
xylitol + NADP+
-
-
-
?
L-erythrulose + NADPH + H+
-
722271
Caenorhabditis elegans
? + NADP+
-
-
-
ir
L-ribulose + NADPH + H+
low activity
722271
Caenorhabditis elegans
? + NADP+
-
-
-
?
L-xylulose + NADPH + H+
-
722271
Caenorhabditis elegans
xylitol + NADP+
-
-
-
ir
additional information
substrate specificity, overview
722271
Caenorhabditis elegans
?
-
-
-
-
additional information
dicarbonyl/L-xylulose reductase is bifunctional
722271
Caenorhabditis elegans
?
-
-
-
-
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.49
-
L-ribulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
1.22
-
D-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
1.8
-
D-erythrose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
2.32
-
D-threose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
3.32
-
L-erythrulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
4.98
-
L-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Caenorhabditis elegans
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
no activity with NADH
Caenorhabditis elegans
NADPH
-
Caenorhabditis elegans
Cloned(Commentary) (protein specific)
Commentary
Organism
gene dhs-21, DNA and amino acid sequence determination and analysis, the dhs-21 gene is physically mapped to the cosmid R11D1 between the sma-1 and mes-4genes on chromosome V, expression of His6-tagged enzyme. Spatial and temporal expression pattern of the DHS-21-GFP construct in transgenic worms, overview
Caenorhabditis elegans
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
no activity with NADH
Caenorhabditis elegans
NADPH
-
Caenorhabditis elegans
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
library screening and isolation of a dhs-21 deletion mutant
Caenorhabditis elegans
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.17
-
L-erythrulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.18
-
L-ribulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.27
-
D-erythrose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.66
-
L-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.68
-
D-threose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
2.58
-
D-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
of spermatids
Caenorhabditis elegans
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-xylulose + NADPH + H+
Caenorhabditis elegans
-
xylitol + NADP+
-
-
ir
additional information
Caenorhabditis elegans
dicarbonyl/L-xylulose reductase is bifunctional
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
gonadal sheath cell
-
Caenorhabditis elegans
-
intestine
-
Caenorhabditis elegans
-
spermathecal-uterine valve
-
Caenorhabditis elegans
-
spermatid
-
Caenorhabditis elegans
-
uterine seam cell
-
Caenorhabditis elegans
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-erythrose + NADPH + H+
-
722271
Caenorhabditis elegans
? + NADP+
-
-
-
ir
D-threose + NADPH + H+
-
722271
Caenorhabditis elegans
? + NADP+
-
-
-
ir
D-xylulose + NADPH + H+
-
722271
Caenorhabditis elegans
xylitol + NADP+
-
-
-
?
L-erythrulose + NADPH + H+
-
722271
Caenorhabditis elegans
? + NADP+
-
-
-
ir
L-ribulose + NADPH + H+
low activity
722271
Caenorhabditis elegans
? + NADP+
-
-
-
?
L-xylulose + NADPH + H+
-
722271
Caenorhabditis elegans
xylitol + NADP+
-
-
-
ir
additional information
substrate specificity, overview
722271
Caenorhabditis elegans
?
-
-
-
-
additional information
dicarbonyl/L-xylulose reductase is bifunctional
722271
Caenorhabditis elegans
?
-
-
-
-
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.49
-
L-ribulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
1.22
-
D-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
1.8
-
D-erythrose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
2.32
-
D-threose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
3.32
-
L-erythrulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
4.98
-
L-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Caenorhabditis elegans
Expression
Organism
Commentary
Expression
Caenorhabditis elegans
knock-down of daf-16 and elt-2 transcription factors affects dhs-21 expression
down
General Information
General Information
Commentary
Organism
malfunction
dhs-21 null mutants show defects in longevity, reproduction and egg-laying
Caenorhabditis elegans
metabolism
dicarbonyl/L-xylulose reductase converts L-xylulose into xylitol, and reduces various alpha-dicarbonyl compounds, performing a dual role in carbohydrate metabolism and detoxification
Caenorhabditis elegans
physiological function
the enzyme is essential for normal life span and reproduction
Caenorhabditis elegans
General Information (protein specific)
General Information
Commentary
Organism
malfunction
dhs-21 null mutants show defects in longevity, reproduction and egg-laying
Caenorhabditis elegans
metabolism
dicarbonyl/L-xylulose reductase converts L-xylulose into xylitol, and reduces various alpha-dicarbonyl compounds, performing a dual role in carbohydrate metabolism and detoxification
Caenorhabditis elegans
physiological function
the enzyme is essential for normal life span and reproduction
Caenorhabditis elegans
Expression (protein specific)
Organism
Commentary
Expression
Caenorhabditis elegans
knock-down of daf-16 and elt-2 transcription factors affects dhs-21 expression
down
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.36
-
L-ribulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.47
-
D-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
3.42
-
D-threose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
6.75
-
D-erythrose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
7.55
-
L-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
19.03
-
L-erythrulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.36
-
L-ribulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
0.47
-
D-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
3.42
-
D-threose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
6.75
-
D-erythrose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
7.55
-
L-xylulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
19.03
-
L-erythrulose
pH 7.0, temperature not specified in the publication
Caenorhabditis elegans
Other publictions for EC 1.1.1.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721689
Metz
A novel L-xylulose reductase e ...
Trichoderma reesei, Trichoderma reesei QM9414
Biochemistry
52
2453-2460
2013
-
-
1
-
1
-
-
5
-
-
1
2
-
4
-
-
1
-
-
-
-
-
13
1
-
-
-
5
2
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
5
-
-
1
2
-
-
-
1
-
-
-
-
13
1
-
-
-
5
2
-
-
-
1
4
4
1
-
-
722271
Son
DHS-21, a dicarbonyl/L-xylulos ...
Caenorhabditis elegans
FEBS Lett.
585
1310-1316
2011
-
-
1
-
1
-
-
6
1
-
-
2
-
2
-
-
-
-
-
5
-
-
8
-
-
-
-
6
1
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
6
1
-
-
2
-
-
-
-
-
5
-
-
8
-
-
-
-
6
1
-
-
-
1
3
3
1
6
6
712023
Mojzita
The true L-xylulose reductase ...
Aspergillus niger
FEBS Lett.
584
3540-3544
2010
-
-
1
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
695778
Matsushika
Efficient bioethanol productio ...
Scheffersomyces stipitis
Appl. Environ. Microbiol.
75
3818-3822
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695829
Hou
Impact of overexpressing NADH ...
Scheffersomyces stipitis
Appl. Microbiol. Biotechnol.
82
909-919
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696889
Krahulec
Engineering of a matched pair ...
Candida tenuis
Biotechnol. J.
4
684-694
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697218
Zhao
Structure/function analysis of ...
Homo sapiens
Cell. Mol. Life Sci.
66
1570-1579
2009
-
-
1
1
-
-
2
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699148
Branco
-
Profiles of xylose reductase, ...
Meyerozyma guilliermondii, Meyerozyma guilliermondii FTI
J. Chem. Technol. Biotechnol.
84
326-330
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699368
Gurpilhares
The behavior of key enzymes of ...
Meyerozyma guilliermondii
J. Ind. Microbiol. Biotechnol.
36
87-93
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686877
Matsunaga
L-Xylulose reductase is involv ...
Homo sapiens
Free Radic. Biol. Med.
44
1191-1202
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687858
Matsushika
Bioethanol production from xyl ...
Scheffersomyces stipitis
J. Biosci. Bioeng.
105
296-299
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695810
Matsushika
Expression of protein engineer ...
Scheffersomyces stipitis
Appl. Microbiol. Biotechnol.
81
243-255
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684552
Nair
Biochemical characterization o ...
Neurospora crassa
Appl. Environ. Microbiol.
73
2001-2004
2007
-
-
1
-
-
-
-
4
-
-
-
-
-
4
-
-
1
-
-
-
-
-
2
-
1
1
-
2
2
2
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
1
-
2
2
2
-
-
-
-
-
-
-
-
688749
Hou
Effect of the reversal of coen ...
Scheffersomyces stipitis
Lett. Appl. Microbiol.
45
184-189
2007
-
-
1
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668392
Matsunaga
Multiplicity of mammalian redu ...
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Drug Metab. Pharmacokinet.
21
1-18
2006
-
-
-
2
-
-
-
-
-
-
-
4
-
7
-
-
-
-
-
8
-
-
8
4
-
-
3
-
-
-
-
4
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
8
-
-
8
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
668491
Sudo
Transgenic mice over-expressin ...
Mus musculus
Exp. Anim.
54
385-394
2005
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670839
El-Kabbani
Structure of the tetrameric fo ...
Homo sapiens, Rattus norvegicus
Proteins
60
424-432
2005
-
-
-
1
4
-
3
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
4
2
-
2
-
-
-
4
1
4
-
2
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656206
Verho
A novel NADH-linked L-xylulose ...
Ambrosiozyma monospora
J. Biol. Chem.
279
14746-14751
2004
-
-
1
-
-
-
-
4
-
1
-
1
-
3
-
-
1
-
-
-
-
-
5
-
1
-
-
-
2
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
4
-
1
-
1
-
-
-
1
-
-
-
-
5
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
656841
Saint-Cyr
P26h and dicarbonyl/L-xylulose ...
Mesocricetus auratus
Mol. Reprod. Dev.
69
137-145
2004
-
-
-
-
-
-
-
-
1
-
1
-
-
4
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657322
El-Kabbani
Crystal structure of human L-x ...
Homo sapiens
Proteins
55
724-732
2004
-
-
1
1
2
-
-
6
-
-
-
1
-
3
-
-
-
1
-
-
-
-
3
-
1
-
-
3
1
-
-
2
-
-
-
-
-
1
2
1
2
-
-
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
654438
Ishikura
Structural determinant for col ...
Homo sapiens, Mus musculus
Biochem. Biophys. Res. Commun.
308
68-72
2003
-
-
1
1
6
-
-
-
-
-
-
-
-
7
-
-
1
2
-
-
-
-
4
3
2
-
2
-
2
-
-
4
-
-
-
-
-
1
4
1
6
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
4
3
2
-
2
-
2
-
-
-
-
-
-
-
-
-
654968
Carbone
Structure-based design of inhi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
13
1469-1474
2003
-
1
-
-
-
-
2
-
2
-
-
1
-
2
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
2
-
-
2
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655222
Ishikura
Identification of amino acid r ...
Rattus norvegicus
Chem. Biol. Interact.
143-144
543-550
2003
-
-
1
-
14
-
1
33
1
-
1
2
-
4
-
-
-
1
-
1
-
-
6
1
1
-
-
5
1
-
-
2
-
-
-
-
-
1
2
-
14
-
-
1
-
33
1
-
1
2
-
-
-
-
-
1
-
-
6
1
1
-
-
5
1
-
-
-
-
-
-
-
-
-
656049
Nakagawa
Molecular characterization of ...
Cavia porcellus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
J. Biol. Chem.
277
17888-17891
2002
-
-
1
-
-
-
41
84
1
-
-
-
-
10
-
-
2
5
-
40
2
-
62
-
5
-
-
84
5
-
-
20
-
-
-
-
-
1
20
-
-
-
-
41
-
84
1
-
-
-
-
-
-
2
-
40
2
-
62
-
5
-
-
84
5
-
-
-
-
-
-
-
-
-
287033
Ishikura
Molecular cloning, expression ...
Cricetinae
Chem. Biol. Interact.
130-132
879-889
2001
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
1
1
-
2
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285666
Metzger
Amino acid substitutions in th ...
Scheffersomyces stipitis
Eur. J. Biochem.
228
50-54
1995
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285665
Witteveen
-
Isolation and characterization ...
Aspergillus niger
Microbiology
140
1679-1685
1994
-
-
-
-
-
-
-
4
-
-
2
1
-
1
-
-
1
-
-
-
2
1
4
1
-
-
-
-
2
2
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
2
1
-
-
-
1
-
-
2
1
4
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
246420
Doten
Inducible xylitol dehydrogenas ...
Erwinia sp., Erwinia sp. 4D2P
J. Bacteriol.
162
845-848
1985
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285658
Doten
Characterization of xylitol-ut ...
Pantoea ananatis
J. Bacteriol.
161
529-533
1985
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
246419
Alizade
Chirality of xylitol-oxidizing ...
Cavia porcellus
FEBS Lett.
67
41-44
1976
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
285660
Lowe
Some applications of insolubil ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
48
1004-1010
1972
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
246414
Hickman
A sensitive and stereospecific ...
Cavia porcellus
J. Biol. Chem.
234
758-761
1959
-
-
-
-
-
-
3
1
-
-
-
-
-
1
-
-
1
-
-
1
-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
-
-
-
-
1
-
1
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
285663
Hollmann
The L-xylulose-xylitol enzyme ...
Cavia porcellus
J. Biol. Chem.
225
87-102
1957
-
-
-
-
-
1
1
-
-
1
-
-
-
1
-
-
-
-
-
1
-
1
2
-
-
-
1
-
1
-
2
2
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
1
2
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
285664
Touster
The reduction of L-xylulose to ...
Cavia porcellus
J. Biol. Chem.
221
697-709
1954
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
2
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
2
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-