Ligand MET-enkephalin

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Basic Ligand Information

Molecular Structure
Picture of MET-enkephalin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H35N5O7S
MET-enkephalin
YFGBQHOOROIVKG-FKBYEOEOSA-N
Synonyms:
(Met)enkephalin, (Met5)-enkephalin, L-methionine enkephalin, Met-5-enkephalin, Met5-enkephalin, methionine-enkephalin, Tyr-Gly-Gly-Phe-L-methionine, Tyr-Gly-Gly-Phe-Met, [Met5]enkephalin, [met5] enkephalins

Show all pahtways known for Show all pathways known for MET-enkephalin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Met-enkephalin + H2O = Met + enkephalin
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Met-enkephalin + H2O = ?
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin = Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O
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-
BAM-22P + H2O = (Met)enkephalin + ?
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-
beta-endorphin + H2O = Met-enkephalin + ?
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-
proenkephalin + H2O = (Met)enkephalin + ?
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-

Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[met5] enkephalins + H2O = Tyr + Met
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Met-enkephalin + H2O = ?
show the reaction diagram
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Met-enkephalin + H2O = ?
show the reaction diagram
-
Met-enkephalin + H2O = ?
show the reaction diagram
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Met-enkephalin + H2O = Tyr-Gly + Gly-Phe-Met
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Tyr-Gly-Gly-Phe-Met + H2O = ?
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Met-enkephalin + H2O = ?
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Tyr-Gly-Gly-Phe-Met + H2O = Tyr-Gly + Gly-Phe-Met
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Met-enkephalin + H2O = ?
show the reaction diagram
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Tyr-Gly-Gly-Phe-Met + H2O = Tyr-Gly-Gly + Phe-Met
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Met-enkephalin + H2O = Tyr-Gly-Gly + Phe-Met
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Tyr-Gly-Gly-Phe-Met + H2O = Tyr-Gly-Gly + Phe-Met
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Tyr-Gly-Gly-Phe-Met + H2O = Tyr-Gly-Gly + Phe-Met
show the reaction diagram
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Met-enkephalin + H2O = ?
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Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-methionine sulfoxide enkephalin + thioredoxin = L-methionine enkephalin
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L-methionine sulfoxide enkephalin + NADPH = L-methionine enkephalin + NADP+ + H2O
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BAM-22P + H2O = (Met)enkephalin + ?
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-
beta-endorphin + H2O = Met-enkephalin + ?
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-
proenkephalin + H2O = (Met)enkephalin + ?
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Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-(NH2) + H2O = Tyr-Gly-Gly-Phe-Met + Arg-Arg-Val-(NH2)
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibitor of dactylysin towards substance P
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
58.3
-
-
3.43
-
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.5, at 37°C
9
-
37°C

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00095
-
-
0.55
-
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.5, at 37°C
0.303
-
-

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.022
-
hydrolysis of Leu5-enkephalin
0.01
-
37°C

References & Links

Links to other databases for MET-enkephalin

ChEBI
PubChem
ChEBI
PubChem