Ligand ethylene glycol

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Basic Ligand Information

Molecular Structure
Picture of ethylene glycol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H6O2
ethylene glycol
LYCAIKOWRPUZTN-UHFFFAOYSA-N
Synonyms:
1,2-ethandiol, 1,2-ethanediol, ethandiol, ethane-1,1-diol, ethane-1,2-diol, ethanediol, ethylene glycoI, ethyleneglycol, ethylenglycol, glycol, hydroxyethanol

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-ethanediol + O2 = ?
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Substrate in Enzyme-catalyzed Reactions (71 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-ethanediol + NADP+ = hydroxyacetaldehyde + NADPH
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ethylene glycol + NAD+ = NADH + ?
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ethane-1,2-diol + NAD+ = glyoxal + NADH
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ethanediol + NADP+ = glyoxal + NADPH
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ethane-1,1-diol + NADP+ = ? + NADPH
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ethylene glycol + NAD+ = glycolaldehyde + NAD+
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ethyleneglycol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
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1,2-ethanediol + ferricyanide = hydroxyacetaldehyde + ferrocyanide
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adenosine 5'-triphosphate + ethylene glycol = adenosine 5'-monophosphate-O-ethylene glycyl ester + H2O + diphosphate
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Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycolaldehyde + NADPH = ethyleneglycol + NADP+
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glyoxal + NADPH = glycol + NADP+
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glycolaldehyde + NADH + H+ = ethane-1,2-diol + NAD+
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bis(2-hydroxyethyl) terephthalic acid + H2O = mono(2-hydroxyethyl)terephthalic acid + ethylene glycol
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2-hydroxyethyl benzoate + H2O = ethane-1,2-diol + benzoate
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2-Hydroxyethyl-phosphate + H2O = Hydroxyethanol + phosphate
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ethylene oxide + H2O = ethane-1,2-diol
show the reaction diagram
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glycolaldehyde hydrate = ethandiol
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Activator in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
addition of ethylene glycol at 33 vol% to the reaction medium for cephalexin synthesis improves the yield from 70% to 95%
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activation
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20% increase of activity at 10% ethylene glycol
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4-8%, 50% activation
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Inhibitor in Enzyme-catalyzed Reactions (73 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition, IC50 4 mM
-
exhibits competitive and uncompetitive inhibition
inhibitory to hydrogen production
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10% (v/v), 60% inhibition
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mixed-type reversible inhibitor, 21.9% inhibition at 1 mM
noncompetitive with sucrose and phosphate
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28% inhibition at 10% (vol/vol)
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34% inhibition at 1%
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80% inhibition at 50%; 80% inhibition at 50% ethylene glycol
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weak
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inactivates the EAL holoenzyme
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3D Structure of Enzyme-Ligand-Complex (PDB) (3629 results)

EC NUMBER
ENZYME 3D STRUCTURE