Ligand 5-chloro-7-iodoquinolin-8-ol

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Basic Ligand Information

Molecular Structure
Picture of 5-chloro-7-iodoquinolin-8-ol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H5ClINO
5-chloro-7-iodoquinolin-8-ol
QCDFBFJGMNKBDO-UHFFFAOYSA-N
Synonyms:
5-chloro-7-iodo-8-quinolinol, clioquinol

Show all pahtways known for Show all pathways known for 5-chloro-7-iodoquinolin-8-ol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl sulfate + 5-chloro-7-iodo-8-quinolinol = adenosine 3',5'-bisphosphate + 5-chloro-7-iodo-8-quinolinyl sulfate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl sulfate + 5-chloro-7-iodo-8-quinolinol = adenosine 3',5'-bisphosphate + 5-chloro-7-iodo-8-quinolinyl sulfate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits isoform SULT1A3-mediated sulfation of dopamine in a dose-dependent manner
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
value above, pH 8, 25C
0.00233
-
at pH 7.5 and 20C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0279
-
using dopamine as substrate, in 0.1 M potassium phosphate buffer (pH 7.4), 1 mM dithiothreitol, 5 mM MgCl2, at 37C
0.0101
-
pH and temperature not specified in the publication

References & Links

Links to other databases for 5-chloro-7-iodoquinolin-8-ol

ChEBI
PubChem
ChEBI
PubChem