Ligand squalene

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Basic Ligand Information

Molecular Structure
Picture of squalene (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C30H50
squalene
YYGNTYWPHWGJRM-AAJYLUCBSA-N
Synonyms:
2,6,10,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexaene

Show all pahtways known for Show all pathways known for squalene

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
squalene + H2O = tetrahymanol
show the reaction diagram
-
squalene + H2O = hopan-22-ol
show the reaction diagram
-
squalene = 8alpha-hydroxypolypoda-13,17,21-triene
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hopan-22-ol = squalene + H2O
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
squalene + H2O = hopan-22-ol
show the reaction diagram
-
squalene = 8alpha-hydroxypolypoda-13,17,21-triene
show the reaction diagram
-
squalene = dammara-20,24-diene
show the reaction diagram
-
squalene = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxysqualene + FADH2 = squalene + FAD + H2O
show the reaction diagram
-
-
presqualene diphosphate + NADPH + H+ = squalene + diphosphate + NADP+
show the reaction diagram
-
-
hopan-22-ol = squalene + H2O
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50 is 0.0012 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (44 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (66 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.018
-
pH 7.0, 30°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0012
-
IC50 is 0.0012 mM

References & Links

Links to other databases for squalene

ChEBI
PubChem
ChEBI
PubChem