Ligand tetrachloromethane

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Basic Ligand Information

Molecular Structure
Picture of tetrachloromethane (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CCl
tetrachloromethane
VZGDMQKNWNREIO-UHFFFAOYSA-N
Synonyms:
carbon tetrachloride, CCl4

Show all pahtways known for Show all pathways known for tetrachloromethane

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tetrachloromethane + reduced acceptor = ? + chloride + acceptor
show the reaction diagram
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tetrachloromethane + H2O = ? + chloride
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
causes marked increases in hepatic TrxR1 activity
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CCl4, major increase in the transcript for choline kinase alpha expression in livers from mice 3 h and 6 h after administration of carbon tetrachloride. CK-beta is unaffected by the carbon tetrachloride treatment. Choline kinase activity is induced in murine livers by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK-alpha and Ck-alpha protein.; CK activity is induced by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK alpha and CK alpha protein. The transcriptional activity of CK alpha was markedly increased 3 h and 6 h after treatment with carbon tetrachloride. Carbon tetrachloride promotes the expression of the transcription factor activator protein 1 (AP-1) that increases CK expression and activity.
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livers from wild type mice treated with CCl4 (1.25 ml/kg) release 2-3fold higher levels of adenosine than livers from comparably treated CD73KO mice
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a single dose of 1589 mg/kg body weight of carbon tetrachloride causes changes in CGL activity and glutathione content in multiple organs of deer mice. Hepatic GCL activity and GSH content are depleted substantially, renal GCL activity increases. Blood, brain and heart GCL activities increase, whereas GSH contents decrease significantly
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
depletion of glutathione levels reduces MAT I/III activities in vivo
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inhibits creatine kinase activity in cerebellum, the administration of N-acetylcysteine plus deferoxamine reverses the inhibition of creatine kinase activity
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complete inactivation
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a single dose of 1589 mg/kg body weight of carbon tetrachloride causes changes in CGL activity and glutathione content in multiple organs of deer mice. Hepatic GCL activity and GSH content are depleted substantially, renal GCL activity increases. Blood, brain and heart GCL activities increase, whereas GSH contents decrease significantly
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Enzyme Kinetic Parameters

References & Links

Links to other databases for tetrachloromethane

ChEBI
PubChem
ChEBI
PubChem