Ligand dATP

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of dATP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H16N5O12P3
dATP
SUYVUBYJARFZHO-RRKCRQDMSA-N
Synonyms:
2'-dATP, 2'-deoxy-adenosine 5'-triphosphate, 2'-deoxy-ATP, 2'-deoxyadenosine 5'-triphosphate, 2'-deoxyATP, 2-dATP, 2-deoxyadenosine 5'-triphosphate, 2-DeoxyATP, 5'-dATP, Deoxy-ATP, deoxyadenosine 5'-triphosphate, deoxyATP

Show all pahtways known for Show all pathways known for dATP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cob(I)alamin + dATP + H2O + H+ = deoxyadenosylcobalamin + diphosphate + phosphate
show the reaction diagram
-
dATP + H2O = dADP + phosphate
show the reaction diagram
-
dATP + H2O = ?
show the reaction diagram
-
dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA
show the reaction diagram
-
dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dADP + (phosphate)n+1 = dATP + (phosphate)n
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (552 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R
show the reaction diagram
-
dATP + citrate + CoA = dADP + phosphate + acetyl-CoA + oxaloacetate
show the reaction diagram
-
dimethylallyl diphosphate + dATP = ?
show the reaction diagram
-
dimethylallyl diphosphate + dATP = diphosphate + N6-(dimethylallyl)dATP
show the reaction diagram
-
2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate
show the reaction diagram
-
dATP + 5-methylthioribose = dADP + 5-methylthioribose 1-phosphate
show the reaction diagram
-
2'-deoxy-ATP + sn-1,2-dihexanoylglycerol = 2'-deoxy-ADP + sn-1,2-dihexanoylglycerol 3-phosphate
show the reaction diagram
-
dATP + D-fructose 6-phosphate = dADP + D-fructose 1,6-bisphosphate
show the reaction diagram
-
dATP + D-ribose = dADP + D-ribose 5-phosphate
show the reaction diagram
-
dATP + adenosylcobinamide = adenosylcobinamide phosphate + dADP
show the reaction diagram
-
dATP + L-seryl-tRNASec = dADP + O-phospho-L-seryl-tRNASec
show the reaction diagram
-
dATP + adenosine 5-phosphosulfate = dADP + 3'-phosphoadenosine 5'-phosphosulfate
show the reaction diagram
-
pantothenate + dATP = 4'-phosphopantothenate + dADP
show the reaction diagram
-
dATP + mevalonate = dADP + phosphomevalonate
show the reaction diagram
-
dATP + D-fructose = dADP + D-fructose 6-phosphate
show the reaction diagram
-
dATP + D-glucuronate = dADP + 1-phospho-D-glucuronate
show the reaction diagram
-
dATP + 4-methyl-5-(2-hydroxyethyl)thiazole = dADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
-
dATP + N-acetyl-D-glucosamine = dADP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
-
dATP + glucose = dADP + D-glucose 6-phosphate
show the reaction diagram
-
2'-deoxy-ATP + scyllo-inosamine = 2'-deoxy-ADP + scyllo-inosamine phosphate
show the reaction diagram
-
dATP + D-mannose = dADP + D-mannose 6-phosphate
show the reaction diagram
-
2'-deoxyATP + shikimate = 2'-deoxyADP + shikimate 3-phosphate
show the reaction diagram
-
dATP + streptomycin = dADP + streptomycin 6-phosphate
show the reaction diagram
-
dATP + deoxycytidine = dADP + dCMP
show the reaction diagram
-
dATP + deoxyadenosine = dADP + dAMP
show the reaction diagram
-
dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] = dADP + ?
show the reaction diagram
-
dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
show the reaction diagram
-
dATP + N-acetyl-L-glutamate = dADP + N-acetyl-L-glutamate 5-phosphate
show the reaction diagram
-
2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate = 2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
show the reaction diagram
-
dATP + 5-methyldeoxycytidine 5'-phosphate = dADP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
-
dATP + CMP = dADP + CDP
show the reaction diagram
-
dATP + dTMP = dADP + dTDP
show the reaction diagram
-
dATP + UMP = dADP + UDP
show the reaction diagram
-
dATP + D-ribose 5-phosphate = dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
-
dATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = dAMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
show the reaction diagram
-
dATP + GTP = dAMP + guanosine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
dATP + RNA = diphosphate + ?
show the reaction diagram
-
dATP + alpha-D-glucose 1-phosphate = dADP-glucose + diphosphate
show the reaction diagram
2'-deoxy-ATP + pantetheine 4'-phosphate = ?
show the reaction diagram
-
dATP + DNAn = diphosphate + DNAn+1
show the reaction diagram
-
dATP + SO42- = diphosphate + deoxyadenylylsulfate
show the reaction diagram
-
dATP + tobramycin = diphosphate + 2''-adenylyltobramycin
show the reaction diagram
-
2'-deoxy-ATP + RNAn = diphosphate + RNAn+1
show the reaction diagram
-
p-tRNAHis + dATP + GTP = pppGp-tRNAHis + dAMP + diphosphate
show the reaction diagram
-
dATP + alpha-D-glucose 1-phosphate = diphosphate + dADP-alpha-D-glucose
show the reaction diagram
-
2'-dATP + pyruvate + phosphate = ?
show the reaction diagram
-
dATP + H2O = ?
show the reaction diagram
-
5'-dATP + H2O = ?
show the reaction diagram
-
dATP + H2O = ?
show the reaction diagram
dATP + H2O = deoxyadenosine + triphosphate
show the reaction diagram
-
dATP + H2O = ?
show the reaction diagram
-
dATP + H2O = dITP + NH3
show the reaction diagram
-
dATP + H2O = dITP + NH3
show the reaction diagram
-
dATP + H2O = dADP + phosphate
show the reaction diagram
-
dATP + H2O = dAMP + diphosphate
show the reaction diagram
-
dATP + H2O = dADP + phosphate
show the reaction diagram
-
dATP + H2O = ?
show the reaction diagram
-
dATP + H2O = ?
show the reaction diagram
-
dATP + H2O = dAMP + diphosphate
show the reaction diagram
-
dATP + H2O = dADP + phosphate
show the reaction diagram
-
dATP + H2O = dADP + phosphate
show the reaction diagram
-
dATP + H2O = dAMP + diphosphate
show the reaction diagram
-
dATP + H2O = dAMP + diphosphate
show the reaction diagram
-
dATP + H2O = dADP + H2O
show the reaction diagram
-
2'-deoxyATP + H2O + H+/in + K+/out = 2'-deoxyADP + phosphate + H+/out + K+/in
show the reaction diagram
-
dATP + H2O + H+/in = dADP + phosphate + H+/out
show the reaction diagram
-
dATP + 5-diphosphomevalonate = dADP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
-
dATP = deoxy-cAMP + diphosphate
show the reaction diagram
-
2'-deoxyadenosine 5'-triphosphate + L-arginine + tRNAArg = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
show the reaction diagram
-
2'-deoxyadenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe
show the reaction diagram
-
dATP + L-histidine + tRNAHis = dAMP + diphosphate + L-histidyl-tRNAHis
show the reaction diagram
-
2'-dATP + L-leucine + tRNALeu = 2'-dAMP + diphosphate + L-leucyl-tRNALeu
show the reaction diagram
-
dATP + lysine + tRNALys = dAMP + L-lysyl-tRNALys + diphosphate
show the reaction diagram
-
dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA
show the reaction diagram
-
dATP + a fatty acid + [acyl-carrier protein] = dAMP + diphosphate + fatty acid-[acyl-carrier protein]
show the reaction diagram
-
dATP + acetate + citrate (pro-3S)-lyase = dAMP + diphosphate + citrate(pro-3S)-lyase
show the reaction diagram
-
dATP + fatty acid + CoA = dAMP + diphosphate + acyl-CoA
show the reaction diagram
-
dATP + cholate + CoA = dAMP + diphosphate + choloyl-CoA
show the reaction diagram
-
dATP + deamido-NAD+ + NH3 = dAMP + diphosphate + NAD+
show the reaction diagram
-
dATP + 7,8-dihydropteroate + L-Glu = dADP + phosphate + 7,8-dihydrofolate
show the reaction diagram
-
dATP + gamma-Glu-L-Cys + Gly = dADP + phosphate + glutathione
show the reaction diagram
-
dATP + 5-formyltetrahydrofolate = dADP + phosphate + 5,10-methylenetetrahydrofolate
show the reaction diagram
-
deoxyATP + UTP + NH4+ = deoxyADP + phosphate + CTP
show the reaction diagram
-
dATP + formate + tetrahydrofolate = dADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
-
dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate
show the reaction diagram
-
dATP + urea + HCO3- = ?
show the reaction diagram
-
dATP + acetyl-CoA + HCO3- = dADP + phosphate + malonyl-CoA
show the reaction diagram
-
dATP + (ribonucleotide)n + (ribonucleotide)m = dAMP + phosphate + (ribonucleotide)n+m
show the reaction diagram
-
dATP + hydrogenobyrinic acid a,c-diamide + Co2+ = dADP + phosphate + cob(II)yrinic acid a,c-diamide + H+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-methyl-dATP + 2-oxoglutarate + O2 = dATP + formaldehyde + succinate + CO2
show the reaction diagram
-
-
dADP + phosphoenolpyruvate = dATP + pyruvate
show the reaction diagram
-
-
dADP + phospholombricine = dATP + lombricine
show the reaction diagram
-
-
dADP + phosphoramide = dATP + NH3
show the reaction diagram
-
-
2'-deoxyadenosine adenosine tetraphosphate + H2O = ATP + 2'-dAMP + 2'-dATP + AMP
show the reaction diagram
-
dADP + phosphate + acetyl-CoA = dATP + acetate + CoA
show the reaction diagram
-
-

Enzyme Cofactor/Cosubstrate (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates
-
activation, can replace ATP to some extent
-
about 25% of the activity with ATP
-
activation
-
best cofactor, Pcal_1127 exhibits slightly higher activity with dATP compared to ATP as diphosphate donor
-

Activator in Enzyme-catalyzed Reactions (155 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
nearly as effective as ATP
-
both dATP and dGTP are co-activators for hydrolysis of dTTP, dATP might bind at the secondary allosteric site
-
activates
-
at least 2fold enhancement of enzyme activity, maximal at 20 microM, similar results with all four deoxynucleoside triphosphates
-
poor allosteric activator
-

Inhibitor in Enzyme-catalyzed Reactions (434 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
18% inhibition at 0.5 mM
-
4% inhibition
-
strong feedback inhibition, tight binding at the active site in stoichiometric amount
-
with ATP as substrate
-
more than 95% inhibition at 0.3 mM
inhibition at 1 mM
-
mechanism of Mn2+-dependent inhibition
-
IC50 above 0.5 mM
-
5 mM, 28C, presence of MgCl2, 39% residual activity
-
synthesis of the short RNA chains is inhibited at all levels of dATP added, and the size of oligo(rA) chains formed and the amount of ATP incorporated are reduced
-
purine triphosphate nucleotides (RTP) behave as non-competitive inhibitors, furthermore PARN does not discriminate whether there is ribose or deoxyribose in the nucleotides, Mg2+ releases the inhibition by RDPs and RTPs, but not by RMPs
-