Ligand captopril

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Basic Ligand Information

Molecular Structure
Picture of captopril (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H15NO3S
captopril
FAKRSMQSSFJEIM-RQJHMYQMSA-N
Synonyms:
3-Mercapto-2-D-methylpropanoyl-L-proline, L-captopril

Show all pahtways known for Show all pathways known for captopril

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
formaldehyde + captopril + NAD+ = S-formylcaptopril + NADH
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5-10 mM, the best enhancement (30%) is achieved using 10 mM
-
solECE, activity 106.9%
-

Inhibitor in Enzyme-catalyzed Reactions (86 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
-
20 mM, 46.6% decrease of activity
-
inhibits isozyme PD I dose-dependently, but shows no inhibition of isozyme PD II at 0.1 mM
-
feeding angiotensin converting enzyme inhibitor captopril down-regulates trypsin activity in the larval gut, injecting third instar larvae with a combination of Aedes aegypti trypsin-modulating oostatic factor and captopril downregulates trypsin biosynthesis in the larval gut
-
0.005 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

Ki Value (25 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.000003
-
-
0.057
-
pH 7.4, 37°C
0.41
-
pH and temperature not specified in the publication
0.042
-
pH 7.0, 30°C, 1.0 M NaCl, 0.002 mM Zn2+

IC50 Value (16 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00951
-
-
0.63
-
-
0.05
-
isozyme PD I, pH 7.8, 37°C
40
-
-

References & Links

Links to other databases for captopril

ChEBI
PubChem
ChEBI
PubChem