Ligand isoprenaline

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Basic Ligand Information

Molecular Structure
Picture of isoprenaline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H17NO3
isoprenaline
JWZZKOKVBUJMES-UHFFFAOYSA-N
Synonyms:
(+/-)isoproterenol, 4-(1-hydroxy-2-isopropylamino-ethyl)-benzene-1,2-diol, beta-adrenergic agonist isopreterenol, DL-isoproterenol, isoproterenol, L-isoproterenol

Show all pahtways known for Show all pathways known for isoprenaline

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
isoproterenol + NAD+ = 1-(3,4-dihydroxyphenyl)-2-[(propan-2-yl)amino]ethane-1-one + NADH + H+
show the reaction diagram
-
DL-isoproterenol + O2 = ?
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
type II
-
induction of enzyme in organ cell culture
-
activates
-
crossactivation at high levels above 0.001 mM in vivo
-
stimulates the phosphorylation activity of GRK5 by10-15fold at 0.001 mM
-
80% activation at up to 0.01 mM
-
stimulates enzyme expression, can be blocked by specific beta-adrenoreceptor antagonists, e.g. actinomycin D
-
stimulates enzyme expression, can be blocked by specific beta-adrenoreceptor antagonists, e.g. actinomycin D
-
intrabrachial isoproterenol (0.03 mcirog/100 ml per minute) induces a significant increase in t-PA release, an effect blunted by NG-monomethyl-L-arginine
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
29.4
-
-
29.4
-
-

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.1
-
-
7.1
-
-

References & Links

Links to other databases for isoprenaline

ChEBI
PubChem
ChEBI
PubChem