Reference on EC 6.5.1.8 - 3'-phosphate/5'-hydroxy nucleic acid ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tanaka, N.; Shuman, S.
RtcB is the RNA ligase component of an Escherichia coli RNA repair operon
J. Biol. Chem.
286
7727-7731
2011
Escherichia coli (P46850)
Desai, K.K.; Raines, R.T.
tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3-phosphate and 5-hydroxyl termini
Biochemistry
51
1333-1335
2012
Pyrococcus furiosus (Q8U0H4)
Desai, K.K.; Bingman, C.A.; Phillips, G.N.; Raines, R.T.
Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation
Biochemistry
52
2518-2525
2013
Pyrococcus furiosus (Q8U0H4)
Poothong, J.; Tirasophon, W.; Kaufman, R.
Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response
Biosci. Rep.
37
BSR20160574
2017
Escherichia coli, Homo sapiens (Q9Y3I0)
Kosmaczewski, S.G.; Edwards, T.J.; Han, S.M.; Eckwahl, M.J.; Meyer, B.I.; Peach, S.; Hesselberth, J.R.; Wolin, S.L.; Hammarlund, M.
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response
EMBO Rep.
15
1278-1285
2014
Caenorhabditis elegans (P90838), Caenorhabditis elegans
Maughan, W.P.; Shuman, S.
Characterization of 3-phosphate RNA ligase paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus highlights DNA and RNA 5'-phosphate capping activity of RtcB3
J. Bacteriol.
197
3616-3624
2015
Myxococcus xanthus (Q1D2I5), Myxococcus xanthus (Q1DFL2), Myxococcus xanthus, Myxococcus xanthus DK 1622 (Q1D2I5), Myxococcus xanthus DK 1622 (Q1DFL2)
Tanaka, N.; Meineke, B.; Shuman, S.
RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo
J. Biol. Chem.
286
30253-30257
2011
Escherichia coli (P46850)
Tanaka, N.; Chakravarty, A.K.; Maughan, B.; Shuman, S.
Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-phosphate/5'-hydroxyl ligation reactions
J. Biol. Chem.
286
43134-43143
2011
Escherichia coli (P46850)
Lu, Y.; Liang, F.X.; Wang, X.
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB
Mol. Cell
55
758-770
2014
Mus musculus (Q99LF4)
Chakravarty, A.K.; Shuman, S.
The sequential 2',3'-cyclic phosphodiesterase and 3'-phosphate/5'-OH ligation steps of the RtcB RNA splicing pathway are GTP-dependent
Nucleic Acids Res.
40
8558-8567
2012
Escherichia coli (P46850)
Desai, K.K.; Cheng, C.L.; Bingman, C.A.; Phillips, G.N.; Raines, R.T.
A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation
Nucleic Acids Res.
42
3931-3942
2014
Pyrococcus horikoshii (O59245), Pyrococcus horikoshii DSM 12428 (O59245)
Temmel, H.; Mueller, C.; Sauert, M.; Vesper, O.; Reiss, A.; Popow, J.; Martinez, J.; Moll, I.
The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli
Nucleic Acids Res.
45
4708-4721
2017
Escherichia coli
Englert, M.; Sheppard, K.; Aslanian, A.; Yates, J.R.; Soell, D.
Archaeal 3-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation
Proc. Natl. Acad. Sci. USA
108
1290-1295
2011
Pyrococcus horikoshii (O59245), Methanopyrus kandleri (Q8TUS2), Pyrobaculum aerophilum (Q8ZY09), Pyrobaculum aerophilum DSM 7523 (Q8ZY09), Pyrococcus horikoshii DSM 12428 (O59245), Methanopyrus kandleri DSM 6324 (Q8TUS2)
Englert, M.; Xia, S.; Okada, C.; Nakamura, A.; Tanavde, V.; Yao, M.; Eom, S.H.; Konigsberg, W.H.; Soell, D.; Wang, J.
Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3-terminal phosphate and 5-OH
Proc. Natl. Acad. Sci. USA
109
15235-15240
2012
Pyrococcus horikoshii (O59245), Pyrococcus horikoshii, Pyrococcus horikoshii DSM 12428 (O59245)
Chakravarty, A.K.; Subbotin, R.; Chait, B.T.; Shuman, S.
RNA ligase RtcB splices 3-phosphate and 5-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3)pp(5)G intermediates
Proc. Natl. Acad. Sci. USA
109
6072-6077
2012
Escherichia coli (P46850)
Desai, K.K.; Beltrame, A.L.; Raines, R.T.
Coevolution of RtcB and Archease created a multiple-turnover RNA ligase
RNA
21
1866-1872
2015
Thermus thermophilus, Thermobifida fusca
Maughan, W.; Shuman, S.
Distinct contributions of enzymic functional groups to the 2',3'-cyclic phosphodiesterase, 3'-phosphate guanylylation, and 3'-ppG/5'-OH ligation steps of the Escherichia coli RtcB nucleic acid splicing pathway
J. Bacteriol.
198
1294-1304
2016
Escherichia coli
Ray, A.; Zhang, S.; Rentas, C.; Caldwell, K.A.; Caldwell, G.A.
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway
J. Neurosci.
34
16076-16085
2014
Caenorhabditis elegans
Popow, J.; Jurkin, J.; Schleiffer, A.; Martinez, J.
Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors
Nature
511
104-107
2014
Homo sapiens
Peach, S.E.; York, K.; Hesselberth, J.R.
Global analysis of RNA cleavage by 5-hydroxyl RNA sequencing
Nucleic Acids Res.
43
e108
2015
Escherichia coli
Remus, B.S.; Goldgur, Y.; Shuman, S.
Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase
Nucleic Acids Res.
45
12945-12953
2017
Candida albicans
Kosmaczewski, S.; Han, S.; Han, B.; Meyer, B.; Baig, H.; Athar, W.; Lin-Moore, A.; Koelle, M.; Hammarlund, M.
RNA ligation in neurons by RtcB inhibits axon regeneration
Proc. Natl. Acad. Sci. USA
112
8451-8456
2015
Caenorhabditis elegans
Nandy, A.; Saenz-Mendez, P.; Gorman, A.M.; Samali, A.; Eriksson, L.A.
Homology model of the human tRNA splicing ligase RtcB
Proteins
85
1983-1993
2017
Homo sapiens (Q9Y3I0)
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