Information on EC 6.5.1.8 - 3'-phosphate/5'-hydroxy nucleic acid ligase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
6.5.1.8
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RECOMMENDED NAME
GeneOntology No.
3'-phosphate/5'-hydroxy nucleic acid ligase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O = (ribonucleotide)n+m + GMP + diphosphate
show the reaction diagram
(2) overall reaction
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(ribonucleotide)n-2',3'-cyclophosphate + H2O = (ribonucleotide)n-3'-phosphate
show the reaction diagram
(2a)
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(ribonucleotide)n-3'-(5'-diphosphoguanosine) + 5'-hydroxy-(ribonucleotide)m = (ribonucleotide)n+m + GMP
show the reaction diagram
(1c); (2d)
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(ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP = (ribonucleotide)n+m + GMP + diphosphate
show the reaction diagram
(1) overall reaction
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5'-guanosyl [RNA ligase]-Ntau-phosphono-L-histidine + (ribonucleotide)n-3'-phosphate = (ribonucleotide)n-3'-(5'-diphosphoguanosine) + [RNA ligase]-L-histidine
show the reaction diagram
(1b); catalytic reaction mechanism, detailed overview
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GTP + [RNA ligase]-L-histidine = 5'-guanosyl [RNA ligase]-Ntau-phosphono-L-histidine + diphosphate
show the reaction diagram
(1a); (2b)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
tRNA splicing II
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SYSTEMATIC NAME
IUBMB Comments
poly(ribonucleotide)-3'-phosphate:5'-hydroxy-poly(ribonucleotide) ligase (GMP-forming)
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