Reference on EC 6.5.1.2 - DNA ligase (NAD+)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Engler, M.J.; Richardson, C.C.
DNA ligases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
15
3-29
1982
Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
-
Maunders, M.J.
DNA and RNA ligases (EC 6.5.1.1, EC 6.5.1.2, and EC 6.5.1.3)
Methods Mol. Biol.
16
213-230
1993
Bacillus subtilis, Escherichia coli, Thermus thermophilus, Salmonella enterica subsp. enterica serovar Typhimurium
Takahashi, M.; Uchida, T.
Thermophilic HB8 DNA ligase: effects of polyethylene glycols and polyamines on blunt-end ligation of DNA
J. Biochem.
100
123-131
1986
Thermus thermophilus
Hayashi, K.; Nakazawa, M.; Ishizaki, Y.; Hiraoka, N.; Obayashi, A.
Stimulation of intermolecular ligation with E. coli DNA ligase by high concentrations of monovalent cations in polyethylene glycol solutions
Nucleic Acids Res.
13
7979-7992
1985
Escherichia coli
Takahashi, M.; Yamaguchi, E.; Uchida, T.
Thermophilic DNA ligase. Purification and properties of the enzyme from Thermus thermophilus HB8
J. Biol. Chem.
259
10041-10047
1984
Thermus thermophilus
Zimmerman, S.B.; Pheiffer, B.H.
Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli
Proc. Natl. Acad. Sci. USA
80
5852-5856
1983
Escherichia coli
Higgins, N.P.; Cozzarelli, N.R.
DNA-joining enzymes: A review
Methods Enzymol.
68
50-71
1979
Escherichia coli
Shibata, T.; Hayase, E.; Ando, T.
Simultaneous preparation of a DNA ligase and restriction endonucleases from Bacillus amyloliquefaciens
Agric. Biol. Chem.
42
1613-1615
1978
Bacillus amyloliquefaciens
-
Panasenko, S.M.; Alazard, R.J.; Lehman, I.R.
A simple, three-step procedure for the large scale purification of DNA ligase from a hybrid lysogen constructed in vitro
J. Biol. Chem.
253
4590-4592
1978
Escherichia coli
Modrich, P.; Anraku, Y.; Lehman, I.R.
Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogenous enzyme from Escherichia coli
J. Biol. Chem.
248
7475-7501
1973
Escherichia coli
-
Nozaki, T.; Masutani, M.; Noda, T.; Saito, D.; Sugiyama, T.; Takato, T.; Wakabayashi, K.; Nakagama, H.; Sugimura, T.
Helicobacter pylori extracts exhibit nicotinamide adenine dinucleotide-derived adenylation but not mono(adenosine 5'-diphosphate-ribosyl)ation of DNA ligase
Jpn. J. Cancer Res.
88
921-924
1997
Helicobacter pylori
Luo, J.; Barany, F.
Identification of essential residues in Thermus thermophilus DNA ligase
Nucleic Acids Res.
24
3079-3085
1996
Thermus thermophilus
Thorbjarnardottir, S.H.; Jonsson, Z.O.; Andresson, O.S.; Kristjansson, J.K.; Eggertsson, G.; Palsdottir, A.
Cloning sequence analysis of the DNA ligase-encoding gene of Rhodothermus marinus, and overproduction, purification and characterization of two thermophilic DNA ligase
Gene
161
1-6
1995
Thermus thermophilus, Thermus scotoductus, Rhodothermus marinus (P49421), Rhodothermus marinus
Jonsson, Z.O.; Thorbjarnardottir, S.H.; Eggertsson, G.; Palsdottir, A.
Sequence of the DNA ligase-encoding gene from thermus scotoductus and conserved motifs in DNA ligases
Gene
151
177-180
1994
Thermus scotoductus
Lee, J.Y.; Kim, H.K.; Chang, C.; Eom, S.H.; Hwang, K.Y.; Cho, Y.; Yu, Y.G.; Ryu, S.E.; Kwon, S.T.; Suh, S.W.
Crystallization and preliminary x-ray crystallographic analysis of NAD+-dependent DNA ligase from Thermus filiformis
Acta Crystallogr. Sect. D
D56
357-358
2000
Thermus filiformis
-
Lim, J.H.; Choi, J.; Kim, W.; Ahn, B.Y.; Han, Y.S.
Mutational analyses of Aquifex pyrophilus DNA ligase define essential domains for self-adenylation and DNA binding activity
Arch. Biochem. Biophys.
388
253-260
2001
Aquifex pyrophilus
Cao, W.
DNA ligases: Structure, function and mechanism
Curr. Org. Chem.
6
827-839
2002
Aquifex aeolicus, Bacillus subtilis, Melanoplus sanguinipes, Amsacta moorei entomopoxvirus
-
Lee, J.Y.; Chang, C.; Song, H.K.; Moon, J.; Yang, J.K.; Kim, H.K.; Kwon, S.T.; Suh, S.W.
Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications
EMBO J.
19
1119-1129
2000
Thermus filiformis (Q9ZHI0), Thermus filiformis
Georlette, D.; Jonsson, Z.O.; Van Petegem, F.; Chessa, J.P.; Van Beeumen, J.; Hubscher, U.; Gerday, C.
A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures
Eur. J. Biochem.
267
3502-3512
2000
Escherichia coli, Thermus scotoductus, Pseudoalteromonas haloplanktis (Q9RBF2)
Lim, J.H.; Choi, J.; Han, S.J.; Kim, S.H.; Hwang, H.Z.; Jin, D.K.; Ahn, B.Y.; Han, Y.S.
Molecular cloning and characterization of thermostable DNA ligase from Aquifex pyrophilus, a hyperthermophilic bacterium
Extremophiles
5
161-168
2001
Escherichia coli, Thermus aquaticus, Aquifex pyrophilus (Q9F150)
Kaczmarek, F.S.; Zaniewski, R.P.; Gootz, T.D.; Danley, D.E.; Mansour, M.N.; Griffor, M.; Kamath, A.V.; Cronan, M.; Mueller, J.; Sun, D.; Martin, P.K.; Benton, B.; McDowell, L.; Biek, D.; Schmid, M.B.
Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus
J. Bacteriol.
183
3016-3024
2001
Staphylococcus aureus
Sriskanda, V.; Moyer, R.W.; Shuman, S.
NAD+-dependent DNA ligase encoded by a eukaryotic virus
J. Biol. Chem.
276
36100-36109
2001
Amsacta moorei entomopoxvirus
Sriskanda, V.; Shuman, S.
Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+
J. Biol. Chem.
277
9695-9700
2002
Escherichia coli
Brotz-Oesterhelt, H.; Knezevic, I.; Bartel, S.; Lampe, T.; Warnecke-Eberz, U.; Ziegelbauer, K.; Habich, D.; Labischinski, H.
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones
J. Biol. Chem.
278
39435-39442
2003
Escherichia coli
Georlette, D.; Blaise, V.; Dohmen, C.; Bouillenne, F.; Damien, B.; Depiereux, E.; Gerday, C.; Uversky, V.N.; Feller, G.
Cofactor Binding modulates the conformational stabilities and unfolding patterns of NAD+-dependent DNA ligases from Escherichia coli and Thermus scotoductus
J. Biol. Chem.
278
49945-49953
2003
Escherichia coli, Thermus scotoductus
Timson, D.J.; Wigley, D.B.
Functional domains of an NAD+-dependent DNA ligase
J. Mol. Biol.
285
73-83
1999
Geobacillus stearothermophilus
Sriskanda, V.; Schwer, B.; Ho, C.K.; Shuman, S.
Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4
Nucleic Acids Res.
27
3953-3963
1999
Escherichia coli
Tong, J.; Barany, F.; Cao, W.
Ligation reaction specificities of an NAD+-dependent DNA ligase from the hyperthermophile Aquifex aeolicus
Nucleic Acids Res.
28
1447-1454
2000
Aquifex aeolicus (O66880), Aquifex aeolicus
Sriskanda, V.; Shuman, S.
A second NAD+-dependent DNA ligase (LigB) in Escherichia coli
Nucleic Acids Res.
29
4930-4934
2001
Escherichia coli
Wilkinson, A.; Sayer, H.; Bullard, D.; Smith, A.; Day, J.; Kieser, T.; Bowater, R.
NAD+-dependent DNA ligases of Mycobacterium tuberculosis and Streptomyces coelicolor
Proteins Struct. Funct. Genet.
51
321-326
2003
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Singleton, M.R.; Hakansson, K.; Timson, D.J.; Wigley, D.B.
Structure of the adenylation domain of an NAD+-dependent DNA ligase
Structure
7
35-42
1999
Geobacillus stearothermophilus
Zauner, G.; Wang, Y.; Lavesa-Curto, M.; MacDonald, A.; Mayes, A.G.; Bowater, R.P.; Butt, J.N.
Tethered DNA hairpins facilitate electrochemical detection of DNA ligation
Analyst
130
345-349
2005
Escherichia coli
Gul, S.; Brown, R.; May, E.; Mazzulla, M.; Smyth, M.G.; Berry, C.; Morby, A.; Powell, D.J.
Staphylococcus aureus DNA ligase: characterization of its kinetics of catalysis and development of a high-throughput screening compatible chemiluminescent hybridization protection assay
Biochem. J.
383
551-559
2004
Staphylococcus aureus
Feng, H.; Parker, J.M.; Lu, J.; Cao, W.
Effects of deletion and site-directed mutations on ligation steps of NAD+-dependent DNA ligase: a biochemical analysis of BRCA1 C-terminal domain
Biochemistry
43
12648-12659
2004
Thermus sp. AK16D
Lu, J.; Tong, J.; Feng, H.; Huang, J.; Afonso, C.L.; Rock, D.L.; Barany, F.; Cao, W.
Unique ligation properties of eukaryotic NAD+-dependent DNA ligase from Melanoplus sanguinipes entomopoxvirus
Biochim. Biophys. Acta
1701
37-48
2004
Melanoplus sanguinipes
Wilkinson, A.; Smith, A.; Bullard, D.; Lavesa-Curto, M.; Sayer, H.; Bonner, A.; Hemmings, A.; Bowater, R.
Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA)
Biochim. Biophys. Acta
1749
113-122
2005
Escherichia coli
Georlette, D.; Blaise, V.; Bouillenne, F.; Damien, B.; Thorbjarnardottir, S.H.; Depiereux, E.; Gerday, C.; Uversky, V.N.; Feller, G.
Adenylation-dependent conformation and unfolding pathways of the NAD+-dependent DNA ligase from the thermophile Thermus scotoductus
Biophys. J.
86
1089-1104
2004
Thermus scotoductus
Jeon, H.J.; Shin, H.J.; Choi, J.J.; Hoe, H.S.; Kim, H.K.; Suh, S.W.; Kwon, S.T.
Mutational analyses of the thermostable NAD+-dependent DNA ligase from Thermus filiformis
FEMS Microbiol. Lett.
237
111-118
2004
Thermus filiformis
Gong, C.; Martins, A.; Bongiorno, P.; Glickman, M.; Shuman, S.
Biochemical and genetic analysis of the four DNA ligases of mycobacteria
J. Biol. Chem.
279
20594-20606
2004
Mycobacterium tuberculosis
Zhu, H.; Shuman, S.
Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA)
J. Biol. Chem.
280
12137-12144
2005
Escherichia coli
Srivastava, S.K.; Tripathi, R.P.; Ramachandran, R.
NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors
J. Biol. Chem.
280
30273-30281
2005
Mycobacterium tuberculosis (P9WNV1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNV1)
Muerhoff, A.S.; Dawson, G.J.; Desai, S.M.
A non-isotopic method for the determination of activity of the thermostable NAD-dependent DNA ligase from Thermus thermophilus HB8
J. Virol. Methods
119
171-176
2004
Thermus thermophilus HB8
Lavesa-Curto, M.; Sayer, H.; Bullard, D.; MacDonald, A.; Wilkinson, A.; Smith, A.; Bowater, L.; Hemmings, A.; Bowater, R.P.
Characterization of a temperature-sensitive DNA ligase from Escherichia coli
Microbiology
150
4171-4180
2004
Escherichia coli, Escherichia coli DSM 3757
Gajiwala, K.S.; Pinko, C.
Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal
Structure
12
1449-1459
2004
Enterococcus faecalis (Q837V6)
Feng, H.
Mutational analysis of bacterial NAD+-dependent DNA ligase: role of motif IV in ligation catalysis
Acta Biochim. Biophys. Sin.
39
608-616
2007
Thermus sp., Thermus sp. TAK16D
Miesel, L.; Kravec, C.; Xin, A.T.; McMonagle, P.; Ma, S.; Pichardo, J.; Feld, B.; Barrabee, E.; Palermo, R.
A high-throughput assay for the adenylation reaction of bacterial DNA ligase
Anal. Biochem.
366
9-17
2007
Escherichia coli
Korycka-Machala, M.; Rychta, E.; Brzostek, A.; Sayer, H.R.; Rumijowska-Galewicz, A.; Bowater, R.P.; Dziadek, J.
Evaluation of NAD+-dependent DNA ligase of mycobacteria as a potential target for antibiotics
Antimicrob. Agents Chemother.
51
2888-2897
2007
Mycolicibacterium smegmatis
Poidevin, L.; MacNeill, S.A.
Biochemical characterisation of LigN, an NAD+-dependent DNA ligase from the halophilic euryarchaeon Haloferax volcanii that displays maximal in vitro activity at high salt concentrations
BMC Mol. Biol.
7
44
2006
Haloferax volcanii
Blasius, M.; Buob, R.; Shevelev, I.V.; Hubscher, U.
Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans
BMC Mol. Biol.
8
69
2007
Deinococcus radiodurans
Tomkinson, A.E.; Vijayakumar, S.; Pascal, J.M.; Ellenberger, T.
DNA ligases: Structure, reaction mechanism, and function
Chem. Rev.
106
687-699
2006
Enterococcus faecalis (Q837V6), Thermus filiformis (Q9ZHI0)
Nandakumar, J.; Nair, P.A.; Shuman, S.
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate
Mol. Cell
26
257-271
2007
Escherichia coli (P15042)
Zhao, A.; Gray, F.C.; MacNeill, S.A.
ATP- and NAD+-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii
Mol. Microbiol.
59
743-752
2006
Haloferax volcanii
Srivastava, S.K.; Dube, D.; Kukshal, V.; Jha, A.K.; Hajela, K.; Ramachandran, R.
NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitor
Proteins
69
97-111
2007
Mycobacterium tuberculosis (P9WNV1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNV1)
Benarroch, D.; Shuman, S.
Characterization of mimivirus NAD+-dependent DNA ligase
Virology
353
133-143
2006
Mimivirus
Vacek, J.; Cahova, K.; Palecek, E.; Bullard, D.R.; Lavesa-Curto, M.; Bowater, R.P.; Fojta, M.
Label-free electrochemical monitoring of DNA ligase activity
Anal. Chem.
80
7609-7613
2008
Escherichia coli
Li, J.; Jiang, J.H.; Xu, X.M.; Chu, X.; Jiang, C.; Shen, G.; Yu, R.Q.
Simultaneous identification of point mutations via DNA ligase-mediated gold nanoparticle assembly
Analyst
133
939-945
2008
Escherichia coli
Pascal, J.M.
DNA and RNA ligases: structural variations and shared mechanisms
Curr. Opin. Struct. Biol.
18
96-105
2008
Escherichia coli, Enterococcus faecalis, Thermus filiformis
Meier, T.I.; Yan, D.; Peery, R.B.; McAllister, K.A.; Zook, C.; Peng, S.B.; Zhao, G.
Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases
FEBS J.
275
5258-5271
2008
Streptococcus pneumoniae
Wang, L.K.; Nair, P.A.; Shuman, S.
Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase
J. Biol. Chem.
283
23343-23352
2008
Escherichia coli (P15042)
Dube, D.; Kukshal, V.; Srivastava, S.K.; Tripathi, R.P.; Ramachandran, R.
NAD+-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design
Med. Chem. Res.
17
189-198
2008
Mycobacterium tuberculosis (P9WNV1), Mycobacterium tuberculosis H37Rv (P9WNV1)
-
Dwivedi, N.; Dube, D.; Pandey, J.; Singh, B.; Kukshal, V.; Ramachandran, R.; Tripathi, R.P.
NAD+-dependent DNA ligase: a novel target waiting for the right inhibitor
Med. Res. Rev.
28
545-568
2008
Escherichia coli, Geobacillus stearothermophilus (O87703), Mycobacterium tuberculosis (P9WNV1), Enterococcus faecalis (Q837V6), Thermus filiformis (Q9ZHI0), Mycobacterium tuberculosis H37Rv (P9WNV1)
Le, D.; Hua, X.; Huang, L.; Gao, G.; Lu, H.; Xu, Z.; Tian, B.; Hua, Y.
Biochemical characterization of two DNA ligases from Deinococcus radiodurans
Protein Pept. Lett.
15
600-605
2008
Deinococcus radiodurans
Han, S.; Chang, J.S.; Griffor, M.
Structure of the adenylation domain of NAD+-dependent DNA ligase from Staphylococcus aureus
Acta Crystallogr. Sect. F
65
1078-1082
2009
Staphylococcus aureus (Q9AIU7), Staphylococcus aureus
Luan, Q.; Xue, Y.; Yao, X.; Lu, W.
Hairpin DNA probe based surface plasmon resonance biosensor used for the activity assay of E. coli DNA ligase
Analyst
135
414-418
2010
Escherichia coli
Ignatov, K.B.; Kramarov, V.M.
DNA ligases from thermophilic bacteria enhance PCR amplification of long DNA sequences
Biochemistry
74
557-561
2009
Thermus thermophilus, Thermus aquaticus
Yutin, N.; Koonin, E.V.
Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity
Biol. Direct
4
51
2009
Brachyspira hyodysenteriae, Acanthamoeba polyphaga Mimivirus, Sorangium cellulosum, Aquifex aeolicus VF5, Candidatus Blochmannia floridanus, Acidithiobacillus ferrooxidans ATCC 23270, Melanoplus sanguinipes entomopoxvirus, Amsacta moorei entomopoxvirus, Invertebrate iridescent virus 6, Aedes taeniorhynchus iridescent virus, Ralstonia phage phiRSL1, Lentisphaera araneosa HTCC2155, Marinobacter sp. ELB17, Desulfatibacillum alkenivorans AK-01, Desulfuromonas acetoxidans DSM 684, Natronomonas pharaonis DSM 2160, Haloquadratum walsbyi DSM 16790, Ostreococcus lucimarinus CCE9901, Rickettsia felis URRWXCal2, Methylacidiphilum infernorum V4, Nitratiruptor sp. SB155-2, Leptotrichia buccalis C-1013-b, Dictyostelium discoideum AX4, Borrelia hermsii HS1, Bacillus thuringiensis Bt407, Clostridium carboxidivorans P7, Plesiocystis pacifica SIR-1
Doi, A.; Pack, S.P.; Makino, K.
Comparison of the molecular influences of NO-induced lesions in DNA strands on the reactivity of polynucleotide kinases, DNA ligases and DNA polymerases
J. Biochem.
147
697-703
2010
Tequatrovirus T4, Thermus aquaticus
Shuman, S.
DNA ligases: progress and prospects
J. Biol. Chem.
284
17365-17369
2009
Escherichia coli (P15042), Enterococcus faecalis (Q837V6)
Singh, V.; Somvanshi, P.
Toward the virtual screening of potential drugs in the homology modeled NAD+ dependent DNA ligase from Mycobacterium tuberculosis
Protein Pept. Lett.
17
269-276
2010
Mycobacterium tuberculosis
Mills, S.D.; Eakin, A.E.; Buurman, E.T.; Newman, J.V.; Gao, N.; Huynh, H.; Johnson, K.D.; Lahiri, S.; Shapiro, A.B.; Walkup, G.K.; Yang, W.; Stokes, S.S.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo
Antimicrob. Agents Chemother.
55
1088-1096
2011
Escherichia coli, Escherichia coli MG1655, Haemophilus influenzae, Haemophilus influenzae KW20, Mycoplasma pneumoniae, Mycoplasma pneumoniae M29, Staphylococcus aureus, Staphylococcus aureus RN4220, Streptococcus pneumoniae
Le, Y.; Peng, J.; Pei, J.; Li, H.; Duan, Z.; Shao, W.
Properties of an NAD+-dependent DNA ligase from the hyperthermophile Thermotoga maritima and its application in PCR amplification of long DNA fragments
Enzyme Microb. Technol.
46
113-117
2010
Thermotoga maritima, Thermotoga maritima ATCC 43589
-
Shapiro, A.B.; Eakin, A.E.; Walkup, G.K.; Rivin, O.
A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase
J. Biomol. Screen.
16
486-493
2011
Haemophilus influenzae
Akhoon, B.A.; Gupta, S.K.; Dhaliwal, G.; Srivastava, M.; Gupta, S.K.
Virtual screening of specific chemical compounds by exploring E.coli NAD+-dependent DNA ligase as a target for antibacterial drug discovery
J. Mol. Model.
17
265-273
2011
Escherichia coli
He, X.; Ni, X.; Wang, Y.; Wang, K.; Jian, L.
Electrochemical detection of nicotinamide adenine dinucleotide based on molecular beacon-like DNA and E. coli DNA ligase
Talanta
83
937-942
2011
Escherichia coli
Jahic, H.; Liu, C.F.; Thresher, J.; Livchak, S.; Wang, H.; Ehmann, D.E.
The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds
Biochem. Pharmacol.
84
654-660
2012
Streptococcus pneumoniae
Stokes, S.S.; Huynh, H.; Gowravaram, M.; Albert, R.; Cavero-Tomas, M.; Chen, B.; Harang, J.; Loch, J.T.; Lu, M.; Mullen, G.B.; Zhao, S.; Liu, C.F.; Mills, S.D.
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity
Bioorg. Med. Chem. Lett.
21
4556-4560
2011
Streptococcus pneumoniae, Staphylococcus aureus
Wang, T.; Duncan, L.; Gu, W.; ODowd, H.; Wei, Y.; Perola, E.; Parsons, J.; Gross, C.H.; Moody, C.S.; Arends, S.J.; Charifson, P.S.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
Bioorg. Med. Chem. Lett.
22
3699-3703
2012
Escherichia coli
Surivet, J.P.; Lange, R.; Hubschwerlen, C.; Keck, W.; Specklin, J.L.; Ritz, D.; Bur, D.; Locher, H.; Seiler, P.; Strasser, D.S.; Prade, L.; Kohl, C.; Schmitt, C.; Chapoux, G.; Ilhan, E.; Ekambaram, N.; Athanasiou, A.; Knezevic, A.; Sabato, D.; Chambovey, A.; Gaertner, M.; Enderlin, M.; Boehme, M.; Sipp, S.i.p.p.e.
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
Bioorg. Med. Chem. Lett.
22
6705-6711
2012
Escherichia coli
Murphy-Benenato, K.; Wang, H.; McGuire, H.M.; Davis, H.E.; Gao, N.; Prince, D.B.; Jahic, H.; Stokes, S.S.; Boriack-Sjodin, P.A.
Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations
Bioorg. Med. Chem. Lett.
24
360-366
2014
Streptococcus pneumoniae, Enterococcus faecalis, Haemophilus influenzae, Staphylococcus aureus
Shrivastava, N.; Nag, J.K.; Misra-Bhattacharya, S.
Molecular characterization of NAD+-dependent DNA ligase from Wolbachia endosymbiont of lymphatic filarial parasite Brugia malayi
PLoS ONE
7
e41113
2012
Wolbachia endosymbiont of Brugia malayi
Jiang, C.; Kan, Y.Y.; Jiang, J.H.; Yu, R.Q.
A simple and highly sensitive DNAzyme-based assay for nicotinamide adenine dinucleotide by ligase-mediated inhibition of strand displacement amplification
Anal. Chim. Acta
844
70-74
2014
Escherichia coli
Shrivastava, N.; Nag, J.K.; Pandey, J.; Tripathi, R.P.; Shah, P.; Siddiqi, M.I.; Misra-Bhattacharya, S.
Homology modeling of NAD+-dependent DNA ligase of the Wolbachia endosymbiont of Brugia malayi and its drug target potential using dispiro-cycloalkanones
Antimicrob. Agents Chemother.
59
3736-3747
2015
Wolbachia sp. subsp. Brugia malayi (Q5GS88), Wolbachia sp. subsp. Brugia malayi TRS (Q5GS88)
Murphy-Benenato, K.E.; Gingipalli, L.; Boriack-Sjodin, P.A.; Martinez-Botella, G.; Carcanague, D.; Eyermann, C.J.; Gowravaram, M.; Harang, J.; Hale, M.R.; Ioannidis, G.; Jahic, H.; Johnstone, M.; Kutschke, A.; Laganas, V.A.; Loch, J.T.; Miller, M.D.; Oguto, H.; Patel, S.J.
Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development
Bioorg. Med. Chem. Lett.
25
5172-5177
2015
Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Haemophilus influenzae ARM158, Escherichia coli ARC524, Streptococcus pneumoniae ARC548, Staphylococcus aureus ARC561
Pergolizzi, G.; Wagner, G.K.; Bowater, R.P.
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Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Mycobacterium tuberculosis, Mycoplasma pneumoniae
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Complete steady-state rate equation for DNA ligase and its use for measuring product kinetic parameters of NAD+-dependent DNA ligase from Haemophilus influenzae
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Sorci, L.; Ruggieri, S.; Raffaelli, N.
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Gluconobacter oxydans, Oleidesulfovibrio alaskensis, Desulfovibrio vulgaris, Syntrophotalea carbinolica, Thermotoga maritima, Synechococcus elongatus, Lawsonia intracellularis
Giroux, X.; MacNeill, S.A.
Inhibiting NAD+-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii
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Naphthalimides selectively inhibit the activity of bacterial, replicative DNA ligases and display bactericidal effects against tubercle bacilli
Molecules
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Chauleau, M.; Shuman, S.
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Escherichia coli
Konomura, N.; Arai, N.; Shinohara, T.; Kobayashi, J.; Iwasaki, W.; Ikawa, S.; Kusano, K.; Shibata, T.
Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions
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Escherichia coli
Yadav, N.; Khanam, T.; Shukla, A.; Rai, N.; Hajela, K.; Ramachandran, R.
Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I
Org. Biomol. Chem.
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Mycobacterium tuberculosis
Pergolizzi, G.; Cominetti, M.M.; Butt, J.N.; Field, R.A.; Bowater, R.P.; Wagner, G.K.
Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases
Org. Biomol. Chem.
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2015
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Hale, M.; Brassington, C.; Carcanague, D.; Embrey, K.; Eyermann, C.; Giacobbe, R.; Gingipalli, L.; Gowravaram, M.; Harang, J.; Howard, T.; Ioannidis, G.; Jahic, H.; Kutschke, A.; Laganas, V.; Loch, J.; Miller, M.; Murphy-Benenato, K.; Oguto, H.; Otterbein, L-; Patel, S.J.; Sapiro, A.B.; Boriack-Sjodin, A.
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Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae (P43813), Streptococcus pneumoniae ATCC 10813, Staphylococcus aureus ATCC 29213
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