Reference on EC 6.5.1.1 - DNA ligase (ATP)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lindahl, T.; Barnes, D.E.
Mammalian DNA ligases
Annu. Rev. Biochem.
61
251-281
1992
Ambystoma mexicanum, Tequatrovirus T4, Bos taurus, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mammalia, Pleurodeles sp., Rattus norvegicus, Schizosaccharomyces pombe, Vaccinia virus, Xenopus laevis
Tomkinson, A.E.; Levin, D.S.
Mammalian DNA ligases
BioEssays
19
893-901
1997
Bos taurus, Drosophila melanogaster, Homo sapiens, Mammalia, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Vaccinia virus, Xenopus laevis
Lasko, D.D.; Tomkinson, A.E.; Lindahl, T.
Eukaryotic DNA ligases
Mutat. Res.
236
277-287
1990
Bos taurus, Saccharomyces cerevisiae, Drosophila melanogaster, Mammalia, Schizosaccharomyces pombe, Vaccinia virus
Engler, M.J.; Richardson, C.C.
DNA ligases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
15
3-29
1982
Tequatrovirus T4, Escherichia phage T7, Saccharomyces cerevisiae, eukaryota, Mammalia, Schizosaccharomyces pombe
-
Maunders, M.J.
DNA and RNA ligases (EC 6.5.1.1, EC 6.5.1.2, and EC 6.5.1.3)
Methods Mol. Biol.
16
213-230
1993
Tequatrovirus T4, Escherichia phage T7, Mammalia
Mezzina, M.; Franchi, E.; Izzo, R.; Bertazzoni, U.; Rossignol, J.M.; Sarasin, A.
Variation in DNA ligase structure during repair and replication processes in monkey kidney cells
Biochem. Biophys. Res. Commun.
132
857-863
1985
Chlorocebus aethiops
Mezzina, M.; Rossignol, J.M.; Philippe, M.; Izzo, R.; Bertazzoni, U.; Sarasin, A.
Mammalia DNA ligase. Structure and function in rat-liver tissues
Eur. J. Biochem.
162
325-332
1987
Rattus norvegicus
Rabin, B.A.; Chase, J.W.
DNA ligase from Drosophila melanogaster embryos. Substrate specificity and mechanism of action
J. Biol. Chem.
262
14105-14111
1987
Drosophila melanogaster
Rabin, B.A.; Hawley, R.S.; Chase, J.W.
DNA ligase from Drosophila melanogaster embryos. Purification and physical characterization
J. Biol. Chem.
261
10637-10645
1986
Drosophila melanogaster
Teraoka, H.; Sumikawa, T.; Tsukada, K.
Purification of DNA ligase II from calf thymus and preparation of rabbit antibody against calf thymus DNA ligase II
J. Biol. Chem.
261
6888-6892
1986
Bos taurus
Hayashi, K.; Nakazawa, M.; Ishizaki, Y.; Obayashi, A.
Influence of monovalent cations on the activity of T4 DNA ligase in the presence of polyethylene glycol
Nucleic Acids Res.
13
3261-3271
1985
Tequatrovirus T4
Teraoka, H.; Sawai, M.; Tsukada, K.
DNA ligase from mouse Ehrlich ascites tumor cells
J. Biochem.
95
1529-1532
1984
Mus musculus
Oishi, N.; Shimada, H.
Purification and properties of a DNA ligase from sea urchin embryos
J. Biochem.
95
1187-1192
1984
Hemicentrotus pulcherrimus
Pohl, F.M.; Thomae, R.; Karst, A.
Temperature dependence of the activity of DNA-modifying enzymes: endonucleases and DNA ligase
Eur. J. Biochem.
123
141-152
1982
Tequatrovirus T4
Terakoa, H.; Tsukada, K.
Eukaryotic DNA ligase. Purification and properties of the enzyme from bovine thymus and immunochemical studies of the enzyme from animal tissues
J. Biol. Chem.
257
4758-4763
1982
Bos taurus
Ferretti, L.; Sgaramella, V.
Specific and reversible inhibition of the blunt end joining activity of the T4 DNA ligase
Nucleic Acids Res.
9
3695-3705
1981
Tequatrovirus T4
Tsuruo, T.; Arens, M.; Padmanabhan, R.; Green, M.
Purification and properties of a DNA ligase from a soluble DNA replication complex
Biochim. Biophys. Acta
606
202-213
1980
Homo sapiens
Katouzian, M.; David, J.C.
Low molecular weight DNA ligase of chick embryo
Biochem. Biophys. Res. Commun.
82
1168-1175
1978
Gallus gallus
Moore, S.K.; James, E.
Purification and electrophoretic assay of T4-induced polynucleotide ligase for the in vitro construction of recombinant DNA molecules
Anal. Biochem.
75
545-554
1976
Tequatrovirus T4
Levin, C.J.; Zimmerman, S.B.
A DNA ligase from mitochondria of rat liver
Biochem. Biophys. Res. Commun.
69
514-520
1976
Rattus norvegicus
Pedrali Noy, G.C.F.; Spadari, S; Ciarrocchi, G.; Pedrini, A.M.; Falaschi, A.
Two forms of the DNA ligase of human cells
Eur. J. Biochem.
39
343-351
1973
Homo sapiens
Sderhll, S.; Lindahl, T.
Two DNA ligase activities from calf thymus
Biochem. Biophys. Res. Commun.
53
910-916
1973
Bos taurus
Saucier, J.M.; Laval, F.
DNA ligase activity in crude extracts of fibroblasts and lymphocytes
Biochem. Biophys. Res. Commun.
116
657-662
1983
Homo sapiens
Teraoka, H.; Sawai, M.; Tsukada, K.
Kinetic studies on the reaction catalyzed by DNA ligase from calf thymus
Biochim. Biophys. Acta
747
117-122
1983
Bos taurus
Brown, G.W.; Ray, D.S.
Purification and characterization of DNA ligase I from the trypanosomatid Crithidia fasciculata
Nucleic Acids Res.
20
3905-3910
1992
Crithidia fasciculata
Subramanya, H.S.; Doherty, A.J.; Ashford, S.R.; Wigley, D.B.
Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7
Cell
85
607-615
1996
Escherichia phage T7
Shuman, S.
Vaccinia virus DNA ligase: specificity, fidelity, and inhibition
Biochemistry
34
16138-16147
1995
Vaccinia virus
Sekiguchi, J.; Shuman, S.
Ligation of RNA-containing duplex by vaccinia DNA ligase
Biochemistry
36
9073-9079
1997
Vaccinia virus
Yang, S.; Becker, F.F.; Chan, J.Y.H.
Biochemical characterization of a protein inhibitor for DNA ligase I from human cells
Biochem. Biophys. Res. Commun.
191
1004-1013
1993
Tequatrovirus T4, Homo sapiens
Rossi, R.; Montecucco, A.; Ciarrocchi, G.; Biamonti, G.
Functional characterization of the T4 DNA ligase: a new insight into the mechanism of action
Nucleic Acids Res.
25
2106-2113
1997
Tequatrovirus T4
Cheng, C.; Shuman, S.
Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae
Nucleic Acids Res.
25
1369-1374
1997
Haemophilus influenzae
Johnson, A.P.; Fairman, M.P.
The identification and purification of a novel mammalian DNA ligase
Mutat. Res.
383
205-212
1997
Homo sapiens
Montecucco, A.; Lestingi, M.; Rossignol, J.M.; Elder, R.H.; Ciarrocchi, G.
Lack of discrimination between DNA ligase I and III by two classes of inhibitors, anthracyclines and distamycin
Biochem. Pharmacol.
45
1536-1539
1993
Homo sapiens, Rattus norvegicus
Gallina, A.; Rossi, F.; Milanesi, G.; Rossi, R.; Montecucco, A.; Ciarrocchi, G.
Characterization of human DNA ligase I expressed in a baculovirus-insect cell system
Biochem. J.
312
593-597
1995
Homo sapiens
Tan, G.T.; Lee, S.; Lee, I.S.; Chen, J.; Leitner, P.; Besterman, J.; Kinghorn, A.D.; Pezzuto, J.M.
Natural-product inhibitors of human DNA ligase I
Biochem. J.
314
993-1000
1996
Homo sapiens
Yang, S.W.; Becker, F.F.; Chan, J.Y.H.
Inhibition of human DNA ligase I activity by zinc and cadmium and the fidelity of ligation
Environ. Mol. Mutagen.
28
19-25
1996
Homo sapiens
Matsuda, S.; Sakaguchi, K.; Tsukada, K.; Teraoka, H.
Characterization of DNA ligase from the fungus Coprinus cinereus
Eur. J. Biochem.
237
691-697
1996
Coprinopsis cinerea
Grawunder, U.; Wilm, M.; Wu, X.; Kuleza, P.; Wilson, T.E.; Mann, M.; Lieber, M.R.
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
Nature
388
492-495
1997
Homo sapiens
Husain, I.; Tomkinson, A.E.; Burkhart, W.A.; Moyer, M.B.; Ramos, W.; Mackey, Z.B.; Besterman, J.M.; Chen, J.
Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase
J. Biol. Chem.
270
9683-9690
1995
Tequatrovirus T4, Bos taurus, Rattus norvegicus
Doherty, A.J.; Ashford, S.R.; Subramanya, H.S.; Wigley, D.B.
Bacteriophage T7 DNA ligase. Overexpression, purification, crystallization, and characterization
J. Biol. Chem.
271
11083-11089
1996
Tequatrovirus T4, Escherichia phage T7
Robin, P.; Lindahl, T.
DNA ligase IV from HeLa cell nuclei
J. Biol. Chem.
271
24257-24261
1996
Tequatrovirus T4, Homo sapiens
Montecuccho, A.; Pedrali-Noy, G.; Spadari, S.; Lestingi, M.; Ciarrocchi, G.
Effects of DNA-binding drugs on T4 DNA ligase
Biochem. J.
266
379-384
1990
Escherichia phage T7
Ciarrocchi, G.; Lestingi, M.; Fontana, M.; Spadari, S.; Montecuccho, A.
Correlation between anthracycline structure and human DNA ligase inhibition
Biochem. J.
279
141-146
1991
Homo sapiens
Andaluz, E.; Larriba, G.; Calderone, R.
A Candida albicans gene encoding a DNA ligase
Yeast
12
893-898
1996
Candida albicans
Chen, J.; Tomkinson, A.E.; Ramos, W.; Mackey, Z.B.; Danehower, S.; Walter, C.A.; Schultz, R.A.; Besterman, J.M.; Husain, I.
Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination
Mol. Cell. Biol.
15
5412-5422
1995
Homo sapiens
Wang, Y.C.; Burkhart, W.A.; Mackey, Z.B.; Moyer, M.B.; Ramos, W.; Husain, I.; Chen, J.; Besterman, J.M.; Tomkinson, A.E.
Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation
J. Biol. Chem.
269
31923-31928
1994
Bos taurus, Homo sapiens
Wei, Y.F.; Robins, P.; Carter, K.; Caldecott, K.; Pappin, D.J.; Yu, G.L.; Wang, R.P.; Shell, B.K.; Nash, R.A.; Schar, P.
Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination
Mol. Cell. Biol.
15
3206-3216
1995
Homo sapiens
Li, C.; Cao, L.G.; Wang, Y.L.; Baril, E.F.
Further purification and characterization of a multienzyme complex for DNA synthesis in human cells
J. Cell. Biochem.
53
405-419
1993
Homo sapiens
Yanez, R.J.; Vinuela, E.
African swine fever virus encodes a DNA ligase
Virology
193
531-536
1993
African swine fever virus
Tomkinson, A.E.; Tappe, N.J.; Friedberg, E.C.
DNA ligase I from Saccharomyces cerevisiae: physical and biochemical characterization of the CDC9 gene product
Biochemistry
31
11762-11771
1992
Saccharomyces cerevisiae
Tomkinson, A.E.; Roberts, E.; Daly, G.; Totty, N.F.; Lindahl, T.
Three distinct DNA ligases in mammalian cells
J. Biol. Chem.
266
21728-21735
1991
Bos taurus
Barnes, D.E.; Johnston, L.H.; Kodama, K.; Tomkinson, A.E.; Lasko, D.D.; Lindahl, T.
Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
87
6679-6683
1990
Homo sapiens
Yang, S.W.; Becker, F.F.; Chan, J.Y.
Identification of a specific inhibitor for DNA ligase I in human cells
Proc. Natl. Acad. Sci. USA
89
2227-2231
1992
Homo sapiens
Yang, S.W.; Huang, P.; Plunkett, W.; Becker, F.F.; Chan, J.Y.
Dual mode of inhibition of purified DNA ligase I from human cells by 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate
J. Biol. Chem.
267
2345-2349
1992
Homo sapiens
Elder, R.H.; Montecucco, A.; Carrocchi, G.; Rossignol, J.M.
Rat liver DNA ligase. Catalytic properties of a novel form of DNA ligase
Eur. J. Biochem.
203
53-58
1992
Rattus norvegicus
Elder, R.H.; Rossignol, J.M.
DNA ligases from rat liver. Purification and partial characterization of two molecular forms
Biochemistry
29
6009-6017
1990
Rattus norvegicus
Hardy, S.; Aoufouchi, S.; Thiebaud, P.; Prigent, C.
DNA ligase I from Xenopus leavis eggs
Nucleic Acids Res.
19
701-705
1991
Xenopus laevis
Takahashi, M.; Tomizawa, K.
Purification and characterization of DNA ligase II from Drosophila melanogaster
Eur. J. Biochem.
192
735-740
1990
Drosophila melanogaster
Takahashi, M.; Senshu, M.
Two distinct DNA ligases from Drosophila melanogaster embryos
FEBS Lett.
213
345-352
1987
Drosophila melanogaster
Higashitani, A.; Tabata, S.; Endo, H.; Hotta, Y.
Purification of DNA ligases from mouse testis and their behavior during meiosis
Cell Struct. Funct.
15
67-72
1990
Mus musculus
Lasko, D.D.; Tomkinson, A.E.; Lindahl, T.
Mammalian DNA ligases. Biosynthesis and intracellular localization of DNA ligase I
J. Biol. Chem.
265
12618-12622
1990
Bos taurus
Tomkinson, A.E.; Lasko, D.D.; Daly, G.; Lindahl, T.
Mammalian DNA ligases. Catalytic domain and size of DNA ligase I
J. Biol. Chem.
265
12611-12617
1990
Bos taurus
Magnet, S.; Blanchard, J.S.
Mechanistic and kinetic study of the ATP-dependent DNA ligase of Neisseria meningitidis
Biochemistry
43
710-717
2004
Neisseria meningitidis
Sun, D.; Urrabaz, R.; Kelly, S.; Nguyen, M.; Weitman, S.
Enhancement of DNA ligase I level by gemcitabine in human cancer cells
Clin. Cancer Res.
8
1189-1195
2002
Homo sapiens
Cao, W.
DNA ligases: Structure, function and mechanism
Curr. Org. Chem.
6
827-839
2002
Escherichia phage T7, Vaccinia virus, Chlorella virus
-
Nakatani, M.; Ezaki, S.; Atomi, H.; Imanaka, T.
Substrate recognition and fidelity of strand joining by an archaeal DNA ligase
Eur. J. Biochem.
269
650-656
2002
Thermococcus kodakarensis
Cherepanov, A.V.; de Vries, S.
Kinetics and thermodynamics of nick sealing by T4 DNA ligase
Eur. J. Biochem.
270
4315-4325
2003
Tequatrovirus T4
Sun, D.; Urrabaz, R.; Buzello, C.; Nguyen, M.
Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells
Exp. Cell Res.
280
90-96
2002
Homo sapiens
Lai, X.; Shao, H.; Hao, F.; Huang, L.
Biochemical characterization of an ATP-dependent DNA ligase from the hyperthermophilic crenarchaeon Sulfolobus shibatae
Extremophiles
6
469-477
2002
Saccharolobus shibatae (Q9P9K9), Saccharolobus shibatae
Nakatani, M.; Ezaki, S.; Atomi, H.; Imanaka, T.
A DNA ligase from a hyperthermophilic archaeon with unique cofactor specificity
J. Bacteriol.
182
6424-6433
2000
Thermococcus kodakarensis (Q9HHC4)
Cherepanov, A.; Yildirim, E.; De Vries, S.
Joining of short DNA oligonucleotides with base pair mismatches by T4 DNA ligase
J. Biochem.
129
61-68
2001
Tequatrovirus T4
Mossi, R.; Ferrari, E.; Hubscher, U.
DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair
J. Biol. Chem.
273
14322-14330
1998
Homo sapiens
Mackey, Z.B.; Niedergang, C.; Murcia, J.M.D.; Leppard, J.; Au, K.; Chen, J.; De Murcia, G.; Tomkinson, A.E.
DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III
J. Biol. Chem.
274
21679-21687
1999
Homo sapiens
Tom, S.; Henricksen, L.A.; Park, M.S.; Bambara, R.A.
DNA ligase I and proliferating cell nuclear antigen form a functional complex
J. Biol. Chem.
276
24817-24825
2001
Homo sapiens
Ranalli, T.A.; DeMott, M.S.; Bambara, R.A.
Mechanism underlying replication protein A stimulation of DNA ligase I
J. Biol. Chem.
277
1719-1727
2002
Homo sapiens
Ranalli, T.A.; Tom, S.; Bambara, R.A.
AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair
J. Biol. Chem.
277
41715-41724
2002
Homo sapiens
Kysela, B.; Doherty, A.J.; Chovanec, M.; Stiff, T.; Ameer-Beg, S.M.; Vojnovic, B.; Girard, P.M.; Jeggo, P.A.
Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule
J. Biol. Chem.
278
22466-22474
2003
Homo sapiens
Doherty, A.J.; Wigley, D.B.
Functional domains of an ATP-dependent DNA ligase
J. Mol. Biol.
285
63-71
1999
Escherichia phage T7
Pearson, M.N.; Rohrmann, G.F.
Characterization of a baculovirus-encoded ATP-dependent DNA ligase
J. Virol.
72
9142-9149
1998
Lymantria dispar multiple nucleopolyhedrovirus (Q9YMV2), Lymantria dispar multiple nucleopolyhedrovirus
Tomkinson, A.E.; Mackey, Z.B.
Structure and function of mammalian DNA ligases
Mutat. Res.
407
1-9
1998
Bos taurus, Homo sapiens
Karimi-Busheri, F.; Lee, J.; Tomikson, A.E.; Weinfeld, M.
Repair of DNA strand gaps and nicks containing 3'-phosphate and 5'-hydroxyl termini by purified mammalian enzymes
Nucleic Acids Res.
26
4395-4400
1998
Homo sapiens
Sriskanda, V.; Shuman, S.
Mutational analysis of Chlorella virus DNA ligase: catalytic roles of domain I and motif VI
Nucleic Acids Res.
26
4618-4625
1998
Chlorella virus
Ramos, W.; Liu, G.; Giroux, C.N.; Tomkinson, A.E.
Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV
Nucleic Acids Res.
26
5676-5683
1998
Saccharomyces cerevisiae (Q08387), Saccharomyces cerevisiae
Sriskanda, V.; Kelman, Z.; Hurwitz, J.; Shuman, S.
Characterization of an ATP-dependent DNA ligase from the thermophilic archaeon Methanobacterium thermoautotrophicum
Nucleic Acids Res.
28
2221-2228
2000
Methanothermobacter thermautotrophicus (Q50566), Methanothermobacter thermautotrophicus
Wang, H.; Zeng, Z.C.; Perrault, A.R.; Cheng, X.; Qin, W.; Iliakis, G.
Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
Nucleic Acids Res.
29
1653-1660
2001
Homo sapiens
Wu, Y.Q.; Hohn, B.; Ziemienowicz, A.
Characterization of an ATP-dependent type I DNA ligase from Arabidopsis thaliana
Plant Mol. Biol.
46
161-170
2001
Arabidopsis thaliana
Lamarche, B.J.; Showalter, A.K.; Tsai, M.D.
An error-prone viral DNA ligase
Biochemistry
44
8408-8417
2005
African swine fever virus, Tequatrovirus T4
Wang, H.; Rosidi, B.; Perrault, R.; Wang, M.; Zhang, L.; Windhofer, F.; Iliakis, G.
DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
Cancer Res.
65
4020-4030
2005
Homo sapiens
Goetz, J.D.; Motycka, T.A.; Han, M.; Jasin, M.; Tomkinson, A.E.
Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line
DNA Repair
4
649-654
2005
Homo sapiens
Sinha, K.M.; Hines, J.C.; Ray, D.S.
Cell cycle-dependent localization and properties of a second mitochondrial DNA ligase in Crithidia fasciculata
Eukaryot. Cell
5
54-61
2006
Crithidia fasciculata
Mills, K.D.; Ferguson, D.O.; Essers, J.; Eckersdorff, M.; Kanaar, R.; Alt, F.W.
Rad54 and DNA ligase IV cooperate to maintain mammalian chromatid stability
Genes Dev.
18
1283-1292
2004
Mus musculus
Keppetipola, N.; Shuman, S.
Characterization of a thermophilic ATP-dependent DNA ligase from the euryarchaeon Pyrococcus horikoshii
J. Bacteriol.
187
6902-6908
2005
Pyrococcus horikoshii
Cai, L.; Hu, C.; Shen, S.; Wang, W.; Huang, W.
Characterization of bacteriophage T3 DNA ligase
J. Biochem.
135
397-403
2004
Enterobacteria phage T3
Gong, C.; Martins, A.; Bongiorno, P.; Glickman, M.; Shuman, S.
Biochemical and genetic analysis of the four DNA ligases of mycobacteria
J. Biol. Chem.
279
20594-20606
2004
Mycobacterium tuberculosis
Audebert, M.; Salles, B.; Calsou, P.
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
J. Biol. Chem.
279
55117-55126
2004
Cricetulus griseus
Zhu, H.; Shuman, S.
Novel 3'-ribonuclease and 3'-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D
J. Biol. Chem.
280
25973-25981
2005
Pseudomonas aeruginosa
Zhu, H.; Wang, L.K.; Shuman, S.
Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme
J. Biol. Chem.
280
33707-33715
2005
Pseudomonas aeruginosa
Zhu, H.; Shuman, S.
A primer-dependent polymerase function of Pseudomonas aeruginosa ATP-dependent DNA ligase (LigD)
J. Biol. Chem.
280
418-427
2005
Pseudomonas aeruginosa
Pitcher, R.S.; Tonkin, L.M.; Green, A.J.; Doherty, A.J.
Domain structure of a NHEJ DNA repair ligase from Mycobacterium tuberculosis
J. Mol. Biol.
351
531-544
2005
Mycobacterium tuberculosis
Krishna, T.H.; Mahipal, S.; Sudhakar, A.; Sugimoto, H.; Kalluri, R.; Rao, K.S.
Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase
J. Neurochem.
92
818-823
2005
Rattus norvegicus
Gong, C.; Bongiorno, P.; Martins, A.; Stephanou, N.C.; Zhu, H.; Shuman, S.; Glickman, M.S.
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C
Nat. Struct. Mol. Biol.
12
304-312
2005
Mycolicibacterium smegmatis
Sinha, K.M.; Hines, J.C.; Downey, N.; Ray, D.S.
Mitochondrial DNA ligase in Crithidia fasciculata
Proc. Natl. Acad. Sci. USA
101
4361-4366
2004
Crithidia fasciculata (Q53E04), Crithidia fasciculata
Pang, L.; Li, J.; Jiang, J.; Shen, G.; Yu, R.
DNA point mutation detection based on DNA ligase reaction and nano-Au amplification: a piezoelectric approach
Anal. Biochem.
358
99-103
2006
Escherichia coli
Chen, P.; Li, J.; Zhao, J.; He, L.; Zhang, Z.
Differential dependence on DNA ligase of type II restriction enzymes: a practical way toward ligase-free DNA automation
Biochem. Biophys. Res. Commun.
353
733-737
2007
Tequatrovirus T4
De, A.; Campbell, C.
A novel interaction between DNA ligase III and DNA polymerase gamma plays an essential role in mitochondrial DNA stability
Biochem. J.
402
175-186
2007
Homo sapiens (P49916)
Zhao, X.; Muller, J.G.; Halasyam, M.; David, S.S.; Burrows, C.J.
In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase
Biochemistry
46
3734-3744
2007
Tequatrovirus T4
Wang, Y.; Lamarche, B.J.; Tsai, M.D.
Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity
Biochemistry
46
4962-4976
2007
Homo sapiens (P49917), Homo sapiens
Tomkinson, A.E.; Vijayakumar, S.; Pascal, J.M.; Ellenberger, T.
DNA ligases: Structure, reaction mechanism, and function
Chem. Rev.
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Escherichia phage T7 (P00969), Homo sapiens (P18858)
Petermann, E.; Keil, C.; Oei, S.L.
Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER
DNA Repair
5
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2006
Homo sapiens
Marchetti, C.; Walker, S.A.; Odreman, F.; Vindigni, A.; Doherty, A.J.; Jeggo, P.
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV
DNA Repair
5
788-798
2006
Homo sapiens
Costantini, S.; Woodbine, L.; Andreoli, L.; Jeggo, P.A.; Vindigni, A.
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
DNA Repair
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2007
Homo sapiens
Gu, J.; Lu, H.; Tippin, B.; Shimazaki, N.; Goodman, M.F.; Lieber, M.R.
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
EMBO J.
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Homo sapiens
Jackson, B.R.; Noble, C.; Lavesa-Curto, M.; Bond, P.L.; Bowater, R.P.
Characterization of an ATP-dependent DNA ligase from the acidophilic archaeon "Ferroplasma acidarmanus" Fer1
Extremophiles
11
315-327
2007
Ferroplasma acidarmanus
Akey, D.; Martins, A.; Aniukwu, J.; Glickman, M.S.; Shuman, S.; Berger, J.M.
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D
J. Biol. Chem.
281
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Mycobacterium tuberculosis
Buguliskis, J.S.; Casta, L.J.; Butz, C.E.; Matsumoto, Y.; Taraschi, T.F.
Expression and biochemical characterization of Plasmodium falciparum DNA ligase I
Mol. Biochem. Parasitol.
155
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Plasmodium falciparum
Zhao, A.; Gray, F.C.; MacNeill, S.A.
ATP- and NAD+-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii
Mol. Microbiol.
59
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Haloferax volcanii
Mortusewicz, O.; Rothbauer, U.; Cardoso, M.C.; Leonhardt, H.
Differential recruitment of DNA ligase I and III to DNA repair sites
Nucleic Acids Res.
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Homo sapiens
Vijayakumar, S.; Chapados, B.R.; Schmidt, K.H.; Kolodner, R.D.; Tainer, J.A.; Tomkinson, A.E.
The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase
Nucleic Acids Res.
35
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Saccharomyces cerevisiae
Zhu, H.; Shuman, S.
Characterization of Agrobacterium tumefaciens DNA ligases C and D
Nucleic Acids Res.
35
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2007
Agrobacterium tumefaciens
Cohen, Z.; Bacharach, E.; Lavi, S.
Mouse major satellite DNA is prone to eccDNA formation via DNA ligase IV-dependent pathway
Oncogene
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2006
Mus musculus
Vacek, J.; Cahova, K.; Palecek, E.; Bullard, D.R.; Lavesa-Curto, M.; Bowater, R.P.; Fojta, M.
Label-free electrochemical monitoring of DNA ligase activity
Anal. Chem.
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Tequatrovirus T4
Smagin, V.A.; Mardanov, A.V.; Bonch-Osmolovskaya, E.A.; Ravin, N.V.
Isolation and characteristics of new thermostable DNA ligase from archaea of the genus Thermococcus
Appl. Biochem. Microbiol.
44
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2008
Thermococcus sp. (C0LJI8)
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Lu, S.; Li, Z; Wang, Z.; Ma, X.; Sheng, D.; Ni, J.; Shen, Y.
Spatial subunit distribution and in vitro functions of the novel trimeric PCNA complex from Sulfolobus tokodaii
Biochem. Biophys. Res. Commun.
376
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Sulfurisphaera tokodaii (Q976G4), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q976G4)
Guenther Sillero, M.A.; de Diego, A.; Perez-Zuniga, F.J.; Sillero, A.
Synthesis of bisphosphonate derivatives of ATP by T4 DNA ligase, ubiquitin activating enzyme (E1) and other ligases
Biochem. Pharmacol.
75
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2008
Tequatrovirus T4
Kusumoto, R.; Dawut, L.; Marchetti, C.; Wan Lee, J.; Vindigni, A.; Ramsden, D.; Bohr, V.A.
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing
Biochemistry
47
7548-7556
2008
Homo sapiens
Patel, M.P.; Baum, D.A.; Silverman, S.K.
Improvement of DNA adenylation using T4 DNA ligase with a template strand and a strategically mismatched acceptor strand
Bioorg. Chem.
36
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Tequatrovirus T4
Chen, X.; Zhong, S.; Zhu, X.; Dziegielewska, B.; Ellenberger, T.; Wilson, G.M.; MacKerell, A.D.; Tomkinson, A.E.
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair
Cancer Res.
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Homo sapiens
Pascal, J.M.
DNA and RNA ligases: structural variations and shared mechanisms
Curr. Opin. Struct. Biol.
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Homo sapiens, Pyrococcus furiosus, Saccharolobus solfataricus
Meier, T.I.; Yan, D.; Peery, R.B.; McAllister, K.A.; Zook, C.; Peng, S.B.; Zhao, G.
Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases
FEBS J.
275
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Tequatrovirus T4, Homo sapiens
Kito, H.; Fujikawa, T.; Moriwaki, A.; Tomono, A.; Izawa, M.; Kamakura, T.; Ohashi, M.; Sato, H.; Abe, K.; Nishimura, M.
MgLig4, a homolog of Neurospora crassa Mus-53 (DNA ligase IV), is involved in, but not essential for, non-homologous end-joining events in Magnaporthe grisea
Fungal Genet. Biol.
45
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Pyricularia grisea (B6ZH51), Pyricularia grisea
Cotner-Gohara, E.; Kim, I.K.; Tomkinson, A.E.; Ellenberger, T.
Two DNA-binding and nick recognition modules in human DNA ligase III
J. Biol. Chem.
283
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Homo sapiens
Zhong, S.; Chen, X.; Zhu, X.; Dziegielewska, B.; Bachman, K.E.; Ellenberger, T.; Ballin, J.D.; Wilson, G.M.; Tomkinson, A.E.; MacKerell, A.D.
Identification and validation of human DNA ligase inhibitors using computer-aided drug design
J. Med. Chem.
51
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Homo sapiens (P18858), Homo sapiens
Dwivedi, N.; Dube, D.; Pandey, J.; Singh, B.; Kukshal, V.; Ramachandran, R.; Tripathi, R.P.
NAD+-dependent DNA ligase: a novel target waiting for the right inhibitor
Med. Res. Rev.
28
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2008
Homo sapiens
Friesen, C.; Uhl, M.; Pannicke, U.; Schwarz, K.; Miltner, E.; Debatin, K.M.
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin
Mol. Biol. Cell
19
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2008
Homo sapiens
Liang, L.; Deng, L.; Nguyen, S.C.; Zhao, X.; Maulion, C.D.; Shao, C.; Tischfield, J.A.
Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
Nucleic Acids Res.
36
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2008
Homo sapiens
Jayaram, S.; Ketner, G.; Adachi, N.; Hanakahi, L.A.
Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
Nucleic Acids Res.
36
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2008
Homo sapiens
Riballo, E.; Woodbine, L.; Stiff, T.; Walker, S.A.; Goodarzi, A.A.; Jeggo, P.A.
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation
Nucleic Acids Res.
37
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2008
Homo sapiens
Crut, A.; Nair, P.A.; Koster, D.A.; Shuman, S.; Dekker, N.H.
Dynamics of phosphodiester synthesis by DNA ligase
Proc. Natl. Acad. Sci. USA
105
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2008
Chlorella virus
Cherepanov, A.V.; Doroshenko, E.V.; Matysik, J.; de Vries, S.; de Groot, H.J.
The associative nature of adenylyl transfer catalyzed by T4 DNA ligase
Proc. Natl. Acad. Sci. USA
105
8563-8568
2008
Tequatrovirus T4
Ferrer, M.; Golyshina, O.V.; Beloqui, A.; Boettger, L.H.; Andreu, J.M.; Polaina, J.; De Lacey, A.L.; Trautwein, A.X.; Timmis, K.N.; Golyshin, P.N.
A purple acidophilic di-ferric DNA ligase from Ferroplasma
Proc. Natl. Acad. Sci. USA
105
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2008
Ferroplasma acidiphilum (Q2PCE4), Ferroplasma acidiphilum, Ferroplasma acidiphilum YT / DSM 12658 (Q2PCE4)
Le, D.; Hua, X.; Huang, L.; Gao, G.; Lu, H.; Xu, Z.; Tian, B.; Hua, Y.
Biochemical characterization of two DNA ligases from Deinococcus radiodurans
Protein Pept. Lett.
15
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Deinococcus radiodurans
Tang, H.; Yang, X.; Wang, K.; Tan, W.; Li, H.; He, L.; Liu, B.
RNA-templated single-base mutation detection based on T4 DNA ligase and reverse molecular beacon
Talanta
75
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2008
Tequatrovirus T4
Jayaram, S.; Gilson, T.; Ehrlich, E.S.; Yu, X.F.; Ketner, G.; Hanakahi, L.
E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection
Virology
382
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Homo sapiens
Bezsudnova, E.Y.; Kovalchuk, M.V.; Mardanov, A.V.; Poliakov, K.M.; Popov, V.O.; Ravin, N.V.; Skryabin, K.G.; Smagin, V.A.; Stekhanova, T.N.; Tikhonova, T.V.
Overexpression, purification and crystallization of a thermostable DNA ligase from the archaeon Thermococcus sp. 1519
Acta Crystallogr. Sect. F
65
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Thermococcus sp. (C0LJI8)
Kim, D.J.; Kim, O.; Kim, H.W.; Kim, H.S.; Lee, S.J.; Suh, S.W.
ATP-dependent DNA ligase from Archaeoglobus fulgidus displays a tightly closed conformation
Acta Crystallogr. Sect. F
65
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Archaeoglobus fulgidus (O29632), Archaeoglobus fulgidus
Pack, S.P.; Doi, A.; Choi, Y.S.; Kim, H.B.; Makino, K.
Accurate guanine:cytosine discrimination in T4 DNA ligase-based single nucleotide polymorphism analysis using an oxanine-containing ligation fragment
Anal. Biochem.
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Tequatrovirus T4
Pack, S.P.; Doi, A.; Choi, Y.S.; Kodaki, T.; Makino, K.
Biomolecular response of oxanine in DNA strands to T4 polynucleotide kinase, T4 DNA ligase, and restriction enzymes
Biochem. Biophys. Res. Commun.
391
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Tequatrovirus T4
Sillero, M.A.; de Diego, A.; Tavares, J.E.; Silva, J.A.; Perez-Zuniga, F.J.; Sillero, A.
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases
Biochem. Pharmacol.
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Tequatrovirus T4
Yutin, N.; Koonin, E.V.
Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity
Biol. Direct
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Acanthocystis turfacea chlorella virus 1, Acidobacterium capsulatum ATCC 51196, African swine fever virus, Agrotis segetum granulovirus, Aquifex aeolicus VF5, Arabidopsis thaliana, Archaeoglobus fulgidus DSM 4304, Chthoniobacter flavus, Chthoniobacter flavus Ellin428, Cinqassovirus aeh1, deerpox virus W-848-83, Dictyostelium discoideum, Drosophila melanogaster, Emiliania huxleyi virus 86, Entamoeba histolytica HM-1:IMSS, Enterobacteria phage, Erwinia phage, Escherichia phage V5, Fowlpox virus, Gemmata obscuriglobus UQM 2246, goatpox virus Pellor, Heliothis zea nudivirus, Homo sapiens, Lessievirus bcepil02, Lymantria dispar multiple nucleopolyhedrovirus, Marseillevirus, Methanosarcina acetivorans C2A, Methylibium petroleiphilum PM1, Monosiga brevicollis MX1, myxoma virus, Nanoarchaeum equitans Kin4-M, Nitrosopumilus maritimus SCM1, Okubovirus SPO1, Opitutus terrae PB90-1, Orgyia leucostigma nucleopolyhedrovirus, Ostreococcus virus OsV5, Paramecium bursaria Chlorella virus 1, Planctopirus limnophila DSM 3776, Plutella xylostella granulovirus, Prochlorococcus marinus, Pseudarthrobacter chlorophenolicus A6, Pseudomonas phage F8, Ralstonia phage RSB1, Saccharomyces cerevisiae, Sphingobacterium spiritivorum ATCC 33300, Spodoptera litura granulovirus, Staphylococcus epidermidis RP62A, Staphylothermus marinus F1, Stigmatella aurantiaca DW4/3-1, swinepox virus, Tetrahymena thermophila, Thermobaculum terrenum ATCC BAA-798, Thermofilum pendens Hrk 5, Vaccinia virus, Vibrio phage, Xanthomonas phage, Xylanimonas cellulosilytica DSM 15894
Waterworth, W.M.; Kozak, J.; Provost, C.M.; Bray, C.M.; Angelis, K.J.; West, C.E.
DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks
BMC Plant Biol.
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79
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Arabidopsis thaliana
Chiang, S.C.; Carroll, J.; El-Khamisy, S.F.
TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage
Cell Cycle
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2010
Homo sapiens
Paran, N.; De Silva, F.S.; Senkevich, T.G.; Moss, B.
Cellular DNA ligase I is recruited to cytoplasmic vaccinia virus factories and masks the role of the vaccinia ligase in viral DNA replication
Cell Host Microbe
6
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2009
Homo sapiens
Song, W.; Pascal, J.M.; Ellenberger, T.; Tomkinson, A.E.
The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1
DNA Repair
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2009
Homo sapiens
Shuman, S.
DNA ligases: progress and prospects
J. Biol. Chem.
284
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Chlorella virus
Lopez Castel, A.; Tomkinson, A.E.; Pearson, C.E.
CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair
J. Biol. Chem.
284
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Homo sapiens
Zhu, H.; Shuman, S.
Gap filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA end-binding Ku protein
J. Biol. Chem.
285
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Pseudomonas aeruginosa
Piserchio, A.; Nair, P.A.; Shuman, S.; Ghose, R.
Solution NMR studies of Chlorella virus DNA ligase-adenylate
J. Mol. Biol.
395
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Chlorella virus
Soza, S.; Leva, V.; Vago, R.; Ferrari, G.; Mazzini, G.; Biamonti, G.; Montecucco, A.
DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression
Mol. Cell. Biol.
29
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Homo sapiens
Vijayakumar, S.; Dziegielewska, B.; Levin, D.S.; Song, W.; Yin, J.; Yang, A.; Matsumoto, Y.; Bermudez, V.P.; Hurwitz, J.; Tomkinson, A.E.
Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair
Mol. Cell. Biol.
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Homo sapiens
Wu, P.Y.; Frit, P.; Meesala, S.; Dauvillier, S.; Modesti, M.; Andres, S.N.; Huang, Y.; Sekiguchi, J.; Calsou, P.; Salles, B.; Junop, M.S.
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4
Mol. Cell. Biol.
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Homo sapiens
Kim, J.; Mrksich, M.
Profiling the selectivity of DNA ligases in an array format with mass spectrometry
Nucleic Acids Res.
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Tequatrovirus T4, Thermus aquaticus
Unal, S.; Cerosaletti, K.; Uckan-Cetinkaya, D.; Cetin, M.; Gumruk, F.
A novel mutation in a family with DNA ligase IV deficiency syndrome
Pediatr. Blood Cancer
53
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2009
Homo sapiens
Wang, X.; Dong, P.; Yun, W.; Xu, Y.; He, P.; Fang, Y.
Detection of T4 DNA ligase using a solid-state electrochemiluminescence biosensing switch based on ferrocene-labeled molecular beacon
Talanta
80
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2010
Tequatrovirus T4
Lavine, M.D.; Arrizabalaga, G.
The antibiotic monensin causes cell cycle disruption of Toxoplasma gondii mediated through the DNA repair enzyme TgMSH-1
Antimicrob. Agents Chemother.
55
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2011
Toxoplasma gondii
Kota, S.; Kamble, V.A.; Rajpurohit, Y.S.; Misra, H.S.
ATP-type DNA ligase requires other proteins for its activity in vitro and its operon components for radiation resistance in Deinococcus radiodurans in vivo
Biochem. Cell Biol.
88
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2010
Deinococcus radiodurans
Cotner-Gohara, E.; Kim, I.K.; Hammel, M.; Tainer, J.A.; Tomkinson, A.E.; Ellenberger, T.
Human DNA ligase III recognizes DNA ends bydynamic switching between two DNA-bound states
Biochemistry
49
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2010
Homo sapiens
Ruhanen, H.; Ushakov, K.; Yasukawa, T.
Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells
Biochim. Biophys. Acta
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2011
Homo sapiens
Horspool, D.R.; Coope, R.J.; Holt, R.A.
Efficient assembly of very short oligonucleotides using T4 DNA ligase
BMC Res. Notes
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Tequatrovirus T4
Andreuzza, S.; Li, J.; Guitton, A.; Faure, J.; Casanova, S.; Park, J.; Choi, Y.; Chen, Z.; Berger, F.
DNA LIGASE I exerts a maternal effect on seed development in Arabidopsis thaliana
Development
137
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2010
Arabidopsis thaliana
Paddock, M.N.; Bauman, A.T.; Higdon, R.; Kolker, E.; Takeda, S.; Scharenberg, A.M.
Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair
DNA Repair
10
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2011
Gallus gallus
Fritsch, O.; Burkhalter, M.D.; Kais, S.; Sogo, J.M.; Schaer, P.
DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier
DNA Repair
9
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2010
Saccharomyces cerevisiae
Samai, P.; Shuman, S.
Structure-function analysis of the OB and latch domains of Chlorella virus DNA ligase
J. Biol. Chem.
286
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Chlorella virus
Taylor, M.R.; Conrad, J.A.; Wahl, D.; OBrien, P.J.
Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency
J. Biol. Chem.
286
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Homo sapiens
Cardona-Felix, C.S.; Pastor-Palacios, G.; Cardenas, H.; Azuara-Liceaga, E.; Brieba, L.G.
Biochemical characterization of the DNA ligase I from Entamoeba histolytica
Mol. Biochem. Parasitol.
174
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Entamoeba histolytica (C4M5H3), Entamoeba histolytica, Entamoeba histolytica HM1:IMSS (C4M5H3)
Wright, D.; DeBeaux, A.; Shi, R.; Doherty, A.J.; Harrison, L.
Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining
Mutagenesis
25
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2010
Mycobacterium tuberculosis
Gao, Y.; Katyal, S.; Lee, Y.; Zhao, J.; Rehg, J.; Russell, H.; McKinnon, P.
DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair
Nature
471
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Mus musculus
Simsek, D.; Furda, A.; Gao, Y.; Artus, J.; Brunet, E.; Hadjantonakis, A.K.; Van Houten, B.; Shuman, S.; McKinnon, P.J.; Jasin, M.
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair
Nature
471
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2011
Mus musculus
Cuneo, M.J.; Gabel, S.A.; Krahn, J.M.; Ricker, M.A.; London, R.E.
The structural basis for partitioning of the XRCC1/DNA ligase III-alpha BRCT-mediated dimer complexes
Nucleic Acids Res.
39
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2011
Homo sapiens (P49916)
Waterworth, W.M.; Masnavi, G.; Bhardwaj, R.M.; Jiang, Q.; Bray, C.M.; West, C.E.
A plant DNA ligase is an important determinant of seed longevity
Plant J.
63
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Arabidopsis thaliana (F4HPZ9)
Simsek, D.; Brunet, E.; Wong, S.Y.; Katyal, S.; Gao, Y.; McKinnon, P.J.; Lou, J.; Zhang, L.; Li, J.; Rebar, E.J.; Gregory, P.D.; Holmes, M.C.; Jasin, M.
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation
PLoS Genet.
7
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2011
Mus musculus
Nickens, D.G.; Bardiya, N.; Patterson, J.T.; Burke, D.H.
Template-directed ligation of tethered mononucleotides by T4 DNA ligase for kinase ribozyme selection
PLoS ONE
5
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2010
Tequatrovirus T4
Nishida, H.; Tsuchiya, D.; Ishino, Y.; Morikawa, K.
Overexpression, purification and crystallization of an archaeal DNA ligase from Pyrococcus furiosus
Acta Crystallogr. Sect. F
61
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2005
Pyrococcus furiosus
Sillero, M.A.G.; Montes, M.; de Diego, A.; del Valle, M.; Atencia, E.A.; Sillero, A.
Thermostable Pyrococcus furiosus DNA ligase catalyzes the synthesis of (di)nucleoside polyphosphates
Extremophiles
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2002
Pyrococcus furiosus (P56709), Pyrococcus furiosus
Kiyonari, S.; Takayama, K.; Nishida, H.; Ishino, Y.
Identification of a novel binding motif in Pyrococcus furiosus DNA ligase for the functional interaction with proliferating cell nuclear antigen
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281
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Pyrococcus furiosus (P56709), Pyrococcus furiosus
Nishida, H.; Kiyonari, S.; Ishino, Y.; Morikawa, K.
The closed structure of an archaeal DNA ligase from Pyrococcus furiosus
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Pyrococcus furiosus (P56709), Pyrococcus furiosus
Tanabe, M.; Ishino, S.; Ishino, Y.; Nishida, H.
Mutations of Asp540 and the domain-connecting residues synergistically enhance Pyrococcus furiosus DNA ligase activity
FEBS Lett.
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Pyrococcus furiosus (P56709), Pyrococcus furiosus
Pascal, J.M.; Tsodikov, O.V.; Hura, G.L.; Song, W.; Cotner, E.A.; Classen, S.; Tomkinson, A.E.; Tainer, J.A.; Ellenberger, T.
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA
Mol. Cell.
24
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2006
Saccharolobus solfataricus (Q980T8), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q980T8)
Lan, H.-Y.; Liu, C.; Hendry, P.
Biochemical and enzymatic characterization of a thermostable DNA ligase encoded by thermophilic acidophilic archaebacterium strain JP2
Prog. Biochem. Biophys.
33
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uncultured archaeon
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Thermococcus sp.Petrova, T.; Bezsudnova, E.Y.; Boyko, K.M.; Mardanov, A.V.; Polyakov, K.M.; Volkov, V.V.; Kozin, M.; Ravin, N.V.; Shabalin, I.G.; Skryabin, K.G.; Stekhanova, T.N.; Kovalchuk, M.V.; Popov, V.O.
ATP-dependent DNA ligase from Thermococcus sp. 1519 displays a new arrangement of the OB-fold domain
Acta Crystallogr. Sect. F
68
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2012
Thermococcus sp. (C0LJI8)
Tanabe, M.; Ishino, S.; Yohda, M.; Morikawa, K.; Ishino, Y.; Nishida, H.
Structure-based mutational study of an archaeal DNA ligase towards improvement of ligation activity
ChemBioChem
13
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2012
Pyrococcus furiosus, Thermococcus sp.
Kiyonari, S.; Kamigochi, T.; Ishino, Y.
A single amino acid substitution in the DNA-binding domain of Aeropyrum pernix DNA ligase impairs its interaction with proliferating cell nuclear antigen
Extremophiles
11
675-684
2007
Aeropyrum pernix (Q9YD18), Aeropyrum pernix, Aeropyrum pernix DSM 11879 (Q9YD18)
Kim, J.H.; Lee, K.K.; Sun, Y.; Seo, G.J.; Cho, S.S.; Kwon, S.H.; Kwon, S.T.
Broad nucleotide cofactor specificity of DNA ligase from the hyperthermophilic crenarchaeon Hyperthermus butylicus and its evolutionary significance
Extremophiles
17
515-522
2013
Hyperthermus butylicus
Jeon, S.J.; Ishikawa, K.
A novel ADP-dependent DNA ligase from Aeropyrum pernix K1
FEBS Lett.
550
69-73
2003
Aeropyrum pernix (Q9YD18), Aeropyrum pernix, Aeropyrum pernix DSM 11879 (Q9YD18)
Tome, S.; Panigrahi, G.B.; Lopez Castel, A.; Foiry, L.; Melton, D.W.; Gourdon, G.; Pearson, C.E.
Maternal germline-specific effect of DNA ligase I on CTG/CAG instability
Hum. Mol. Genet.
20
2131-2143
2011
Homo sapiens
Lohman, G.J.; Chen, L.; Evans, T.C.
Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase
J. Biol. Chem.
286
44187-44196
2011
Tequatrovirus T4
Samai, P.; Shuman, S.
Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation
J. Biol. Chem.
287
28609-28618
2012
Paramecium bursaria chlorella virus (O41026)
Arakawa, H.; Bednar, T.; Wang, M.; Paul, K.; Mladenov, E.; Bencsik-Theilen, A.A.; Iliakis, G.
Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells
Nucleic Acids Res.
40
2599-2610
2012
Gallus gallus
Lohman, G.J.; Zhang, Y.; Zhelkovsky, A.M.; Cantor, E.J.; Evans, T.C.
Efficient DNA ligation in DNA-RNA hybrid helices by Chlorella virus DNA ligase
Nucleic Acids Res.
42
1831-1844
2014
Chlorella virus
Paul, K.; Wang, M.; Mladenov, E.; Bencsik-Theilen, A.; Bednar, T.; Wu, W.; Arakawa, H.; Iliakis, G.
DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates
PLoS ONE
8
e59505
2013
Gallus gallus
Wang, Y.; Xie, J.J.; Han, Z.; Liu, J.H.; Liu, X.P.
Expression, purification and biochemical characterization of Methanocaldococcus jannaschii DNA ligase
Protein Expr. Purif.
87
79-86
2013
Methanocaldococcus jannaschii (Q57635), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q57635)
Oscorbin, I.P.; Boyarskikh, U.A.; Zakabunin, A.I.; Khrapov, E.A.; Filipenko, M.L.
DNA-binding domain of DNA ligase from the thermophilic archaeon Pyrococcus abyssi: improving long-range PCR and neutralization of heparin's inhibitory effect
Appl. Biochem. Biotechnol.
176
1859-1869
2015
Pyrococcus abyssi (P0CL74), Pyrococcus abyssi
Williamson, A.; Rothweiler, U.; Leiros, H.K.
Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface
Acta Crystallogr. Sect. D
70
3043-3056
2014
Psychromonas sp. SP041 (A0A0A6YVN6)
Cannone, G.; Xu, Y.; Beattie, T.; Bell, S.; Spagnolo, L.
The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus
Biochem. J.
465
239-245
2015
Saccharolobus solfataricus (Q980T8), Saccharolobus solfataricus
Pezeshgi Modarres, H.; Dorokhov, B.; Popov, V.; Ravin, N.; Skryabin, K.; Dal Peraro, M.
Understanding and engineering thermostability in DNA ligase from Thermococcus sp. 1519
Biochemistry
54
3076-3085
2015
Thermococcus sp. 1519 (C0LJI8)
Pawlowska, R.; Korczynski, D.; Nawrot, B.; Stec, W.J.; Chworos, A.
The alpha-thio and/or beta-gamma-hypophosphate analogs of ATP as cofactors of T4 DNA ligase
Bioorg. Chem.
67
110-115
2016
Tequatrovirus T4
Bhattarai, H.; Gupta, R.; Glickman, M.S.
DNA ligase C1 mediates the LigD-independent nonhomologous end-joining pathway of Mycobacterium smegmatis
J. Bacteriol.
196
3366-3376
2014
Mycolicibacterium smegmatis
Williamson, A.; Hjerde, E.; Kahlke, T.
Analysis of the distribution and evolution of the ATP-dependent DNA ligases of bacteria delineates a distinct phylogenetic group Lig E
Mol. Microbiol.
99
274-290
2016
Campylobacter jejuni, Escherichia coli, Salmonella enterica, Haemophilus influenzae, Staphylococcus aureus, Neisseria meningitidis, Yersinia pestis, Photobacterium profundum, Prochlorococcus marinus, Shewanella oneidensis, Staphylococcus epidermidis, Vibrio parahaemolyticus, Vibrio vulnificus, Aliivibrio salmonicida, Helicobacter pullorum, Vibrio cholerae serotype O1, Helicobacter canadensis, Helicobacter cinaedi, Helicobacter winghamensis
de Ory, A.; Nagler, K.; Carrasco, B.; Raguse, M.; Zafra, O.; Moeller, R.; de Vega, M.
Identification of a conserved 5'-dRP lyase activity in bacterial DNA repair ligase D and its potential role in base excision repair
Nucleic Acids Res.
44
1833-1844
2016
Bacillus subtilis, Pseudomonas aeruginosa
Liu, X.; Huang, A.; Luo, D.; Liu, H.; Han, H.; Xu, Y.; Liang, P.
Use of adenylate kinase as a solubility tag for high level expression of T4 DNA ligase in Escherichia coli
Protein Expr. Purif.
109
79-84
2015
Tequatrovirus T4
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