Reference on EC 6.4.1.1 - pyruvate carboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ahmad, F.; Ahmad, P.M.; Mendez, A.
Rat liver pyruvate carboxylase. Purification, detection and quantification of apo and holo forms by immuno-blotting and by an enzyme-linked immunosorbent assay
Biochem. J.
236
527-533
1986
Homo sapiens, Mammalia, Rattus norvegicus
Osmani, S.A.; Scrutton, M.C.
The sub-cellular localisation and regulatory properties of pyruvate carboxylase from Rhizopus arrhizus
Eur. J. Biochem.
147
119-128
1985
Rhizopus arrhizus
Charles, A.M.; Willer, D.W.
Pyruvate carboxylase from Thiobacillus novellus: properties and possible function
Can. J. Microbiol.
30
532-539
1984
Starkeya novella
-
Sundaram, T.K.; Wood, P.H.; Backburn, N.J.; Marsh A.E.
Pyruvate carboxylase from a thermophilic Bacillus: effect of depletion of bound metal on catalytic activity and structures
Biochem. Soc. Trans.
11
740-741
1983
Bacillus sp. (in: Bacteria)
-
Wood, P.H.; Sundaram, T.K.; Blackburn, N.J.; Marsh, A.E.
Isolation and characterization of pyruvate carboxylase from the extremely thermophilic Bacillus caldotenax
Biochem. Soc. Trans.
11
741-742
1983
[Bacillus] caldotenax
-
Osmani, S.A.; Mayer, F.; Marston, F.A.O.; Selmes, I.P.; Scrutton, M.C.
Pyruvate carboxylase from Aspergillus nidulans. Effects of regulatory modifiers on the structure of the enzyme
Eur. J. Biochem.
139
509-518
1984
Aspergillus nidulans
Gross, J.A.; Cohen, N.D.; Utter, M.F.
Characterization of the subunit structure of pyruvate carboxylase from Pseudomonas citronellolis
J. Biol. Chem.
256
11819-11825
1981
Pseudomonas citronellolis
Osmani, S.A.; Marston, F.A.O.; Selmes, I.P.; Chapman, A.G.; Srutton, M.C.
Pyruvate carboxylase from Aspergillus nidulans. Regulatory properties
Eur. J. Biochem.
118
271-278
1981
Aspergillus nidulans
Charles, A.M.; Butler, B.J.; Willer, D.
Pyruvate carboxylase from the facultative chemolithothrophs Thiobacillus A2 and Thiobacillus novellus
FEMS Microbiol. Lett.
8
9-12
1980
Starkeya novella, Thiobacillus sp., Thiobacillus sp. A2
-
Libor, S.; Sundaram, T.K.; Warwick, R.; Chapman, J.A.; Grundy, S.M.W.
Pyruvate carboxylase from a thermophilic Bacillus: some molecular characteristics
Biochemistry
18
3647-3653
1979
Bacillus sp. (in: Bacteria)
Sandmann, G.; Hilgenberg, W.
Pyruvatcarboxylase aus Phycomyces blakesleaenus
Z. Pflanzenphysiol.
90
415-422
1978
Phycomyces blakesleeanus
-
Libor, S.M.; Sundaram, T.K.; Scrutton, M.C.
Pyruvate carboxylase from a thermophilic Bacillus
Biochem. J.
169
543-558
1978
Bacillus sp. (in: Bacteria), Gallus gallus, Rattus norvegicus, Saccharomyces cerevisiae
Rowan, A.N.; Newsholme, E.A.; Scrutton, M.C.
Partial purification and some properties of pyruvate carboxylase from the flight muscle of the locust Schistocerca gregaria
Biochim. Biophys. Acta
522
270-275
1978
Schistocerca gregaria, Rattus norvegicus, Tenebrio molitor
Gurr, J.A.; Jones, K.M.
Purification and characterization of pyruvate carboxylase from Arthrobacter globiformis
Arch. Biochem. Biophys.
179
444-455
1977
Arthrobacter globiformis
Milrad de Forchetti, S.R.; Cazzulo, J.J.
Some properties of the pyruvate carboxylase from Pseudomonas fluorescens
J. Gen. Microbiol.
93
75-81
1976
Pseudomonas fluorescens
Barden, R.E.; Taylor, B.L.; Isohashi, F.; Frey, W.H.; Zander, G.; Lee, J.C.; Utter, M.F.
Structural properties of pyruvate carboxylase from chicken liver and other sources
Proc. Natl. Acad. Sci. USA
72
4308-4312
1975
Bos taurus, Gallus gallus, Homo sapiens, Meleagris gallopavo, Pseudomonas citronellolis, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa
Mahan, D.E.; Mushahwar, I.K.; Koeppe, R.E.
Purification and properties of rat brain pyruvate carboxylase
Biochem. J.
145
25-35
1975
Rattus norvegicus
Nakashima, K.; Rudolph, F.B.; Wakabayashi, T.; Lardy, H.A.
Rat liver pyruvate carboxylase. V. Reversible dissociation by chloride salts of monovalent cations
J. Biol. Chem.
250
331-336
1975
Rattus norvegicus
Palacian, E.; Neet, K.E.
Pyruvate carboxylase: inactivation by sulfhydryl group reagents in the presence of certain inorganic anions, substrates, and modifiers and the effects on the allosteric properties of the enzyme
Biochim. Biophys. Acta
276
297-312
1972
Gallus gallus
Sundaram, T.K.; Cazzulo, J.J.; Kornberg, H.L.
Anaplerotic CO2 fixation in mesophilic and thermophilic bacilli
Biochim. Biophys. Acta
192
355-357
1969
Weizmannia coagulans, Bacillus licheniformis
Cazzulo, J.J.; Sundaram, T.K.; Kornberg, H.L.
Properties and regulation of pyruvate carboxylase from Bacillus stearothermophilus
Proc. R. Soc. Lond. B Biol. Sci.
176
1-19
1970
Geobacillus stearothermophilus
Scrutton, M.C.; White, M.D.
Pyruvate carboxylase from rat liver: catalytic properties in the absence, and at low concentrations, of acetyl-CoA
Biochem. Biophys. Res. Commun.
48
85-93
1972
Rattus norvegicus
Tozo, K.; Sejalon-Delmas, N.; Jerebzoff-Quintin, S.; Jerebzoff, S.
Pyruvate carboxylase in Leptosphaeria michotii. Isolation, properties, intracellular localization and cyclic variations of its activity in relation to polypeptide level
Physiol. Plant.
86
484-494
1992
Leptosphaeria michotii
-
Phillips, N.F.B.; Snoswsell, M.A.; Chapman-Smith, A.; Keech, D.B.; Wallace, J.C.
Isolation of a carboxyphosphate intermediate and the locus of acetyl-CoA action in the pyruvate carboxylase reaction
Biochemistry
31
9445-9450
1992
Gallus gallus
Dunn, M.F.; Encarnacion, S.; Araiza, G.; Vargas, M.C.; Davalos, A.; Peralta, H.; Mora, Y.; Mora, J.
Pyruvate carboxylase from Rhizobium etli: mutant characterization, nucleotide sequence, and physiological role
J. Bacteriol.
178
5960-5970
1996
Rhizobium etli
Thampy, K.G.; Huang, W.Y.; Wakil, S.J.
A rapid purification method for rat liver pyruvate carboxylase and amino acid sequence analyses of NH2-terminal and biotin peptide
Arch. Biochem. Biophys.
266
270-276
1988
Rattus norvegicus
Griffith, A.D.; Cyr, D.M.; Egan, S.G.; Tremblay, G.C.
Inhibition of pyruvate carboxylase by sequestration of coenzyme A with sodium benzoate
Arch. Biochem. Biophys.
269
201-207
1989
Rattus norvegicus
Werneburg, B.G.; Ash, D.E.
Chemical modifications of chicken liver pyruvate carboxylase: evidence for essential cysteine-lysine pairs and a reactive sulfhydryl-group
Arch. Biochem. Biophys.
303
214-221
1993
Gallus gallus
Attwood, P.V.; Powell, M.
Fluorescent labelling pf pyruvate carboxylase with 4-acetamido-4'-(iodoacetyl)-aminostilbene-2,2'-disulfonic acid (AIDA) provides a means of monitoring substrate binding
Biochem. Soc. Trans.
24
469S
1996
Gallus gallus
Attwood, P.V.; Graneri, B.D.L.A.
The biotin-carboxylation reaction of pyruvate carboxylase: the roles of acetyl CoA, Mg2+ and biotin
Biochem. Soc. Trans.
19
231S
1991
Gallus gallus
Salto, R.; Lahoz, J.M.; del Mar Sola, M.; Oliver, J.; Vargas, A.M.
Purification and characterization of pyruvate carboxylase from rat-kidney cortex
Biochem. Arch.
6
385-395
1990
Rattus norvegicus
-
Graneri, B.D.L.A.; Sotzik, F.H.; Attwood, P.V.
The effect of pH on the binding of ATP and phosphate in the biotin carboxylation reaction of pyruvate carboxylase
Biochem. Soc. Trans.
21
65S
1992
Gallus gallus
Carver, J.A.; Baldwin, G.S.; Keech, D.B.; Bais, R.; Wallace, J.C.
Inactivation of chicken liver pyruvate carboxylase by 1,10-phenanthroline
Biochem. J.
252
501-507
1988
Gallus gallus
Modak, H.V.; Kelly, D.J.
Acetyl-CoA-dependent pyruvate carboxylase from the photosynthetic bacterium Rhodobacter capsulatus: rapid and efficient purification using dye-ligand affinity chromatography
Microbiology
141
2619-2628
1995
Rhodobacter capsulatus
Attwood, P.V.
The structure and the mechanism of action of pyruvate carboxylase
Int. J. Biochem. Cell Biol.
27
231-249
1995
Aspergillus nidulans, Saccharomyces cerevisiae, Gallus gallus, Pseudomonas citronellolis, vertebrata
Mukhopadhyay, B.; Stoddard, S.F.; Wolfe, R.S.
Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum
J. Biol. Chem.
273
5155-5166
1998
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DELTAH
Tu, Z.; Hagedorn, H.H.
Purification and characterization of pyruvate carboxylase from the honeybee and some properties of related biotin-containing proteins in other insects
Arch. Insect Biochem. Physiol.
19
53-66
1992
Aedes aegypti, Apis mellifera
-
Attwood, P.V.; Graneri, B.D.L.A.
Bicarbonate-dependent ATP cleavage catalysed by pyruvate carboxylase in the absence of pyruvate
Biochem. J.
287
1011-1017
1992
Gallus gallus
Chapman-Smith, A.; Booker, G.W.; Clements, P.R.; Wallace, J.C.; Keech, D.B.
Further studies on the localization of the reactive lysyl residue of pyruvate carboxylase
Biochem. J.
276
759-764
1991
Saccharomyces cerevisiae, Ovis aries
Attwood, P.V.; Graneri, B.D.L.A.
Pyruvate carboxylase catalysis of phosphate transfer between carbamoyl phosphate and ADP
Biochem. J.
273
443-448
1991
Gallus gallus
MacKay, N.; Rigat, B.; Douglas, C.; Chen, H.S.; Robinson, B.H.
cDNA cloning of human kidney pyruvate carboxylase
Biochem. Biophys. Res. Commun.
29
1009-1014
1994
Homo sapiens
Wexler, I.D.; Du, Y.; Lisgaris, M.V.; Mandal, S.K.; Freytag, S.O.; Yang, B.S.; Liu, T.C.; Kwon, M.; Patel, M.S.; Kerr, D.S.
Primary amino acid sequence and structure of human pyruvate carboxylase
Biochim. Biophys. Acta
1227
46-52
1994
Homo sapiens
Lim, F.; Morris, C.P.; Occhiodora, F.; Wallace, J.C.
Sequence and domain structure of yeast pyruvate carboxylase
J. Biol. Chem.
263
11493-11497
1988
Saccharomyces cerevisiae
Peters-Wendisch, P.G.; Kreutzer, C.; Kalinowski, J.; Patek, M.; Sahm, H.; Eikmanns, B.J.
Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene
Microbiology
144
915-927
1998
Corynebacterium glutamicum
Yakunin, A.F.; Hallenbeck, P.C.
Regulation of synthesis of pyruvate carboxylase in the photosynthetic bacterium Rhodobacter capsulatus
J. Bacteriol.
179
1460-1468
1997
Rhodobacter capsulatus
Chandler, C.S.; Ballard, F.J.
Distribution and degradation of biotin-containing carboxylases in human cell lines
Biochem. J.
232
385-393
1985
Homo sapiens
Vemuri, G.N.; Eiteman, M.A.; Altman, E.
Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli
Appl. Environ. Microbiol.
68
1715-1727
2002
Rhizobium etli
Koffas, M.A.; Jung, G.Y.; Aon, J.C.; Stephanopoulos, G.
Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum
Appl. Environ. Microbiol.
68
5422-5428
2002
Corynebacterium glutamicum
March, J.C.; Eiteman, M.A.; Altman, E.
Expression of an anaplerotic enzyme, pyruvate carboxylase, improves recombinant protein production in Escherichia coli
Appl. Environ. Microbiol.
68
5620-5624
2002
Escherichia coli
Attwood, P.V.; Geeves, M.A.
Changes in catalytic activity and association state of pyruvate carboxylase which are dependent on enzyme concentration
Arch. Biochem. Biophys.
401
63-72
2002
Gallus gallus
Mukhopadhyay, B.; Patel, V.J.; Wolfe, R.S.
A stable archaeal pyruvate carboxylase from the hyperthermophile Methanococcus jannaschii
Arch. Microbiol.
174
406-414
2000
Methanocaldococcus jannaschii
Dunn, M.F.; Araiza, G.; Finan, T.M.
Cloning and characterization of the pyruvate carboxylase from Sinorhizobium meliloti Rm1021
Arch. Microbiol.
176
355-363
2001
Sinorhizobium meliloti, Sinorhizobium meliloti Rm1021
Jitrapakdee, S.; Walker, M.E.; Wallace, J.C.
Functional expression, purification, and characterization of recombinant human pyruvate carboxylase
Biochem. Biophys. Res. Commun.
266
512-517
1999
Homo sapiens (P11498), Homo sapiens
Jitrapakdee, S.; Wallace, J.C.
Structure, function and regulation of pyruvate carboxylase
Biochem. J.
340
1-16
1999
Geobacillus stearothermophilus, Saccharomyces cerevisiae, Mammalia, Methanothermobacter thermautotrophicus, Rhizobium etli, Homo sapiens (P11498)
-
Carbone, M.A.; Robinson, B.H.
Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer
Biochem. J.
370
275-282
2003
Homo sapiens
Branson, J.P.; Attwood, P.V.
Effects of Mg2+ on the pre-steady-state kinetics of the biotin carboxylation reaction of pyruvate carboxylase
Biochemistry
39
7480-7491
2000
Gallus gallus
Branson, J.P.; Nezic, M.; Wallace, J.C.; Attwood, P.V.
Kinetic characterization of yeast pyruvate carboxylase isozyme pyc1
Biochemistry
41
4459-4466
2002
Saccharomyces cerevisiae
Branson, J.P.; Nezic, M.; Jitrapakdee, S.; Wallace, J.C.; Attwood, P.V.
Kinetic characterization of yeast pyruvate carboxylase isozyme Pyc1 and the Pyc1 mutant, C249A
Biochemistry
43
1075-1081
2004
Saccharomyces cerevisiae
Mukhopadhyay, B.; Purwantini, E.
Pyruvate carboxylase from Mycobacterium smegmatis: stabilization, rapid purification, molecular and biochemical characterization and regulation of the cellular level
Biochim. Biophys. Acta
1475
191-206
2000
Mycolicibacterium smegmatis
Liao, V.H.; Freedman, J.H.
Characterization of a cadmium-inducible isoform of pyruvate carboxylase from Caenorhabditis elegans
DNA Seq.
12
137-145
2001
Caenorhabditis elegans (O17732), Caenorhabditis elegans
Sueda, S.; Islam, M.N.; Kondo, H.
Protein engineering of pyruvate carboxylase
Eur. J. Biochem.
271
1391-1400
2004
Geobacillus thermodenitrificans
Liu, Y.Q.; Jetton, T.L.; Leahy, J.L.
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
J. Biol. Chem.
277
39163-39168
2002
Rattus norvegicus
Irani, N.; Beccaria, A.J.; Wagner, R.
Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells
J. Biotechnol.
93
269-282
2002
Saccharomyces cerevisiae
Peters-Wendisch, P.G.; Schiel, B.; Wendisch, V.F.; Katsoulidis, E.; Mockel, B.; Sahm, H.; Eikmanns, B.J.
Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum
J. Mol. Microbiol. Biotechnol.
3
295-300
2001
Corynebacterium glutamicum
Ozimek, P.; van Dijk, R.; Latchev, K.; Gancedo, C.; Wang, D.Y.; van der Klei, I.J.; Veenhuis, M.
Pyruvate carboxylase is an essential protein in the assembly of yeast peroxisomal oligomeric alcohol oxidase
Mol. Biol. Cell
14
786-797
2003
Ogataea angusta, Ogataea angusta ass3
Kim, Y.H.; Kim, S.S.
Bcl-2 inhibits tumor necrosis factor-alpha-mediated increase of glycolytic enzyme activities and enhances pyruvate carboxylase activity
Mol. Cells
16
67-73
2003
Homo sapiens
Kondo, S.; Nakajima, Y.; Sugio, S.; Yong-Biao, J.; Sueda, S.; Kondo, H.
Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution
Acta Crystallogr. Sect. D
60
486-492
2004
Aquifex aeolicus
Baez-Saldana, A.; Zendejas-Ruiz, I.; Revilla-Monsalve, C.; Islas-Andrade, S.; Cardenas, A.; Rojas-Ochoa, A.; Vilches, A.; Fernandez-Mejia, C.
Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects
Am. J. Clin. Nutr.
79
238-243
2004
Homo sapiens
Agca, C.; Bidwell, C.A.; Donkin, S.S.
Cloning of bovine pyruvate carboxylase and 5' untranslated region variants
Anim. Biotechnol.
15
47-66
2004
Bos taurus
Lin, H.; San, K.Y.; Bennett, G.N.
Effect of Sorghum vulgare phosphoenolpyruvate carboxylase and Lactococcus lactis pyruvate carboxylase coexpression on succinate production in mutant strains of Escherichia coli
Appl. Microbiol. Biotechnol.
67
515-523
2005
Lactococcus lactis
Yong-Biao, J.; Islam, M.N.; Sueda, S.; Kondo, H.
Identification of the catalytic residues involved in the carboxyl transfer of pyruvate carboxylase
Biochemistry
43
5912-5920
2004
Geobacillus thermodenitrificans
Wang, Q.; Wu, C.; Chen, T.; Chen, X.; Zhao, X.
Expression of Galactose Permease and Pyruvate Carboxylase in Escherichia coli ptsG Mutant Increases the Growth Rate and Succinate Yield under Anaerobic Conditions
Biotechnol. Lett.
28
89-93
2006
Bacillus subtilis
Lin, H.; Vadali, R.V.; Bennett, G.N.; San, K.Y.
Increasing the acetyl-CoA pool in the presence of overexpressed phosphoenolpyruvate carboxylase or pyruvate carboxylase enhances succinate production in Escherichia coli
Biotechnol. Prog.
20
1599-1604
2004
Lactococcus lactis
Sanchez, A.M.; Bennett, G.N.; San, K.Y.
Efficient succinic acid production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant
Biotechnol. Prog.
21
358-365
2005
Lactococcus lactis
Fogolin, M.B.; Wagner, R.; Etcheverrigaray, M.; Kratje, R.
Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells
J. Biotechnol.
109
179-191
2004
Saccharomyces cerevisiae
Vlasova, T.I.; Stratton, S.L.; Wells, A.M.; Mock, N.I.; Mock, D.M.
Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood
J. Nutr.
135
42-47
2005
Homo sapiens
Abe, S.; Chamnan, C.; Miyamoto, K.; Minamino, Y.; Nouda, M.
Isolation and identification of 3-methylcrotonyl coenzyme A carboxylase cDNAs and pyruvate carboxylase, and their expression in red seabream (Pagrus major) organs
Mar. Biotechnol.
6
527-540
2004
Pagrus major
-
Kretschmar, U.; Rckert, A.; Jeoung, J.H.; Grisch, H.
Malate: quinone oxidoreductase is essential for growth on ethanol or acetate in pseudomonas aeruginosa
microbiology
148
3839-3847
2002
Pseudomonas aeruginosa
Islam, M.N.; Sueda, S.; Kondo, H.
Construction of new forms of pyruvate carboxylase to assess the allosteric regulation by acetyl-CoA
PROTEIN ENG. DES. SEL.
18
71-78
2005
Geobacillus thermodenitrificans
Lai, H.; Kraszewski, J.L.; Purwantini, E.; Mukhopadhyay, B.
Identification of pyruvate carboxylase genes in Pseudomonas aeruginosa PAO1 and development of a P. aeruginosa-based overexpression system for alpha4- and alpha4beta4-type pyruvate carboxylases
Appl. Environ. Microbiol.
72
7785-7792
2006
Pseudomonas aeruginosa
Kim, S.H.; Lee, G.M.
Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44)
Appl. Microbiol. Biotechnol.
76
659-665
2007
Homo sapiens (P11498), Homo sapiens
Fransson, U.; Rosengren, A.H.; Schuit, F.C.; Renstroem, E.; Mulder, H.
Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets
Diabetologia
49
1578-1586
2006
Rattus norvegicus
Ozimek, P.Z.; Klompmaker, S.H.; Visser, N.; Veenhuis, M.; van der Klei, I.J.
The transcarboxylase domain of pyruvate carboxylase is essential for assembly of the peroxisomal flavoenzyme alcohol oxidase
FEMS Yeast Res.
7
1082-1092
2007
Ogataea angusta
Jitrapakdee, S.; Adina-Zada, A.; Besant, P.G.; Surinya, K.H.; Cleland, W.W.; Wallace, J.C.; Attwood, P.V.
Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA
Int. J. Biochem. Cell Biol.
39
1211-1223
2007
Saccharomyces cerevisiae (P11154), Saccharomyces cerevisiae (P32327), Saccharomyces cerevisiae, Saccharomyces cerevisiae DM18 (P32327)
Jitrapakdee, S.; Surinya, K.H.; Adina-Zada, A.; Polyak, S.W.; Stojkoski, C.; Smyth, R.; Booker, G.W.; Cleland, W.W.; Attwood, P.V.; Wallace, J.C.
Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers
Int. J. Biochem. Cell Biol.
39
2120-2134
2007
Saccharomyces cerevisiae (P11154), Saccharomyces cerevisiae
Jensen, M.V.; Joseph, J.W.; Ilkayeva, O.; Burgess, S.; Lu, D.; Ronnebaum, S.M.; Odegaard, M.; Becker, T.C.; Sherry, A.D.; Newgard, C.B.
Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion
J. Biol. Chem.
281
22342-22351
2006
Rattus norvegicus (P52873)
St Maurice, M.; Reinhardt, L.; Surinya, K.H.; Attwood, P.V.; Wallace, J.C.; Cleland, W.W.; Rayment, I.
Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme
Science
317
1076-1079
2007
Rhizobium etli
Jitrapakdee, S.; St Maurice, M.; Rayment, I.; Cleland, W.W.; Wallace, J.C.; Attwood, P.V.
Structure, mechanism and regulation of pyruvate carboxylase
Biochem. J.
413
369-387
2008
Aquifex aeolicus, Geobacillus thermodenitrificans, Bos taurus, Saccharomyces cerevisiae, Ogataea angusta, Homo sapiens, Methanobacterium sp., Methanococcus sp., Methanosarcina sp., Staphylococcus aureus, Mus musculus, Komagataella pastoris, Pseudomonas sp., Rattus norvegicus, Rhizobium etli
Xu, J.; Han, J.; Long, Y.S.; Epstein, P.N.; Liu, Y.Q.
The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells
Diabetologia
51
2022-2030
2008
Rattus norvegicus
Adina-Zada, A.; Jitrapakdee, S.; Surinya, K.H.; McIldowie, M.J.; Piggott, M.J.; Cleland, W.W.; Wallace, J.C.; Attwood, P.V.
Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme
Int. J. Biochem. Cell Biol.
40
1743-1752
2008
Geobacillus thermodenitrificans
Hazelton, S.R.; Koser, S.L.; Bidwell, C.A.; Donkin, S.S.
Translational efficiency of bovine pyruvate carboxylase 5' untranslated region messenger ribonucleic acid variants
J. Anim. Sci.
86
3401-3408
2008
Bos taurus
Hasan, N.M.; Longacre, M.J.; Stoker, S.W.; Boonsaen, T.; Jitrapakdee, S.; Kendrick, M.A.; Wallace, J.C.; MacDonald, M.J.
Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase
J. Biol. Chem.
283
28048-28059
2008
Rattus norvegicus (P52873)
Hazelton, S.R.; Spurlock, D.M.; Bidwell, C.A.; Donkin, S.S.
Cloning the genomic sequence and identification of promoter regions of bovine pyruvate carboxylase
J. Dairy Sci.
91
91-99
2008
Bos taurus (Q29RK2), Bos taurus
Kukavica-Ibrulj, I.; Sanschagrin, F.; Peterson, A.; Whiteley, M.; Boyle, B.; Mackay, J.; Levesque, R.C.
Functional genomics of PycR, a LysR family transcriptional regulator essential for maintenance of Pseudomonas aeruginosa in the rat lung
Microbiology
154
2106-2118
2008
Pseudomonas aeruginosa
Wang, D.; Yang, H.; De Braganca, K.C.; Lu, J.; Yu Shih, L.; Briones, P.; Lang, T.; De Vivo, D.C.
The molecular basis of pyruvate carboxylase deficiency: mosaicism correlates with prolonged survival
Mol. Genet. Metab.
95
31-38
2008
Homo sapiens
Xiang, S.; Tong, L.
Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction
Nat. Struct. Mol. Biol.
15
295-302
2008
Staphylococcus aureus (A0A0H3JRU9), Staphylococcus aureus, Homo sapiens (P11498), Homo sapiens
Swingley, W.D.; Sadekar, S.; Mastrian, S.D.; Matthies, H.J.; Hao J.; Ramos, H.; Acharya, C.R.; Conrad, A.L.; Taylor, H.L.; Dejesa, L.C.; Shah, M.K.; O'huallachain, M.E.; Lince, M.T.; Blankenship, R.E.; Beatty, J.T.; Touchman, J.W.
The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism
J. Bacteriol.
189
683-690
2007
Roseobacter denitrificans OCh 114
Buch, A.; Archana, G.; Naresh Kumar, G.
Metabolic channeling of glucose towards gluconate in phosphate-solubilizing Pseudomonas aeruginosa P4 under phosphorus deficiency
Res. Microbiol.
159
635-642
2008
Pseudomonas aeruginosa, Pseudomonas aeruginosa P4, Pseudomonas fluorescens
Zeczycki, T.N.; St Maurice, M.; Jitrapakdee, S.; Wallace, J.C.; Attwood, P.V.; Cleland, W.W.
Insight into the carboxyl transferase domain mechanism of pyruvate carboxylase from Rhizobium etli
Biochemistry
48
4305-4313
2009
Rhizobium etli
Monnot, S.; Serre, V.; Chadefaux-Vekemans, B.; Aupetit, J.; Romano, S.; De Lonlay, P.; Rival, J.M.; Munnich, A.; Steffann, J.; Bonnefont, J.P.
Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency
Hum. Mutat.
30
734-740
2009
Homo sapiens
Han, J.; Liu, Y.Q.
Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice
J. Endocrinol.
204
143-152
2010
Mus musculus
Si, Y.; Shi, H.; Lee, K.
Impact of perturbed pyruvate metabolism on adipocyte triglyceride accumulation
Metab. Eng.
11
382-390
2009
Mus musculus
Fan, T.W.; Lane, A.N.; Higashi, R.M.; Farag, M.A.; Gao, H.; Bousamra, M.; Miller, D.M.
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
Mol. Cancer
8
41
2009
Homo sapiens
Yu, L.P.; Xiang, S.; Lasso, G.; Gil, D.; Valle, M.; Tong, L.
A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A
Structure
17
823-832
2009
Staphylococcus aureus (A0A0H3JRU9), Staphylococcus aureus
Adina-Zada, A.; Hazra, R.; Sereeruk, C.; Jitrapakdee, S.; Zeczycki, T.; Maurice, M.; Cleland, W.; Wallace, J.; Attwood, P.
Probing the allosteric activation of pyruvate carboxylase using 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA
Arch. Biochem. Biophys.
509
117-126
2011
Rhizobium etli
Minet, A.D.; Gaster, M.
Pyruvate carboxylase is expressed in human skeletal muscle
Biochem. Biophys. Res. Commun.
402
196-197
2010
Homo sapiens
Duangpan, S.; Jitrapakdee, S.; Adina-Zada, A.; Byrne, L.; Zeczycki, T.N.; St Maurice, M.; Cleland, W.W.; Wallace, J.C.; Attwood, P.V.
Probing the catalytic roles of Arg548 and Gln552 in the carboxyl transferase domain of the Rhizobium etli pyruvate carboxylase by site-directed mutagenesis
Biochemistry
49
3296-3304
2010
Rhizobium etli
Huberts, D.H.; Venselaar, H.; Vriend, G.; Veenhuis, M.; van der Klei, I.J.
The moonlighting function of pyruvate carboxylase resides in the non-catalytic end of the TIM barrel
Biochim. Biophys. Acta
1803
1038-1042
2010
Ogataea angusta
Wallace, J.
My favorite pyruvate carboxylase
IUBMB Life
62
535-538
2010
Homo sapiens, Rattus norvegicus
Schaer, J.; Stoll, R.; Schauer, K.; Loeffler, D.I.; Eylert, E.; Joseph, B.; Eisenreich, W.; Fuchs, T.M.; Goebel, W.
Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes
J. Bacteriol.
192
1774-1784
2010
Listeria monocytogenes, Listeria monocytogenes Sv1/2a EGD-e
Cheng, T.; Sudderth, J.; Yang, C.; Mullen, A.; Jin, E.; Mates, J.; DeBerardinis, R.
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
Proc. Natl. Acad. Sci. USA
108
8674-8679
2011
Homo sapiens
Yovkova, V.; Otto, C.; Aurich, A.; Mauersberger, S.; Barth, G.
Engineering the alpha-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP(+)-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica
Appl. Microbiol. Biotechnol.
98
2003-2013
2014
Yarrowia lipolytica
Zeczycki, T.N.; Menefee, A.L.; Jitrapakdee, S.; Wallace, J.C.; Attwood, P.V.; St Maurice, M.; Cleland, W.W.
Activation and inhibition of pyruvate carboxylase from Rhizobium etli
Biochemistry
50
9694-9707
2011
Rhizobium etli (Q2K340), Rhizobium etli, Rhizobium etli CFN 42 (Q2K340)
Adina-Zada, A.; Sereeruk, C.; Jitrapakdee, S.; Zeczycki, T.N.; St Maurice, M.; Cleland, W.W.; Wallace, J.C.; Attwood, P.V.
Roles of Arg427 and Arg472 in the binding and allosteric effects of acetyl CoA in pyruvate carboxylase
Biochemistry
51
8208-8217
2012
Rhizobium etli (Q2K340), Rhizobium etli, Rhizobium etli CFN 42 (Q2K340)
Marlier, J.F.; Cleland, W.W.; Zeczycki, T.N.
Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli
Biochemistry
52
2888-2894
2013
Rhizobium etli
Adina-Zada, A.; Jitrapakdee, S.; Wallace, J.C.; Attwood, P.V.
Coordinating Role of His216 in MgATP Binding and Cleavage in Pyruvate Carboxylase
Biochemistry
53
1051-1058
2014
Rhizobium etli (Q2K340), Rhizobium etli CFN 42 (Q2K340)
Tsuji, Y.; Suzuki, I.; Shiraiwa, Y.
Enzymological evidence for the function of a plastid-located pyruvate carboxylase in the Haptophyte alga Emiliania huxleyi: a novel pathway for the production of C4 compounds
Plant Cell Physiol.
53
1043-1052
2012
Emiliania huxleyi (B9X0T8), Emiliania huxleyi
Songserm, P.; Thitiprasert, S.; Tolieng, V.; Piluk, J.; Tanasupawat, S.; Assabumrungrat, S.; Yang, S.T.; Karnchanatat, A.; Thongchul, N.
Regulating pyruvate carboxylase in the living culture of Aspergillus terreus Nrrl 1960 by L-aspartate for enhanced itaconic acid production
Appl. Biochem. Biotechnol.
177
595-609
2015
Aspergillus terreus, Aspergillus terreus Nrrl 1960
Lietzan, A.D.; Lin, Y.; St Maurice, M.
The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase
Arch. Biochem. Biophys.
562
70-79
2014
Rhizobium etli (Q2K340), Rhizobium etli, Rhizobium etli ATCC 51251 (Q2K340)
Sirithanakorn, C.; Adina-Zada, A.; Wallace, J.C.; Jitrapakdee, S.; Attwood, P.V.
Mechanisms of inhibition of Rhizobium etli pyruvate carboxylase by L-aspartate
Biochemistry
53
7100-7106
2014
Rhizobium etli (Q2K340), Rhizobium etli, Rhizobium etli ATCC 51251 (Q2K340)
Westerhold, L.E.; Adams, S.L.; Bergman, H.L.; Zeczycki, T.N.
Pyruvate occupancy in the carboxyl transferase domain of pyruvate carboxylase facilitates product release from the biotin carboxylase domain through an intermolecular mechanism
Biochemistry
55
3447-3460
2016
Rhizobium etli (Q2K340), Rhizobium etli ATCC 51251 (Q2K340)
Sirithanakorn, C.; Jitrapakdee, S.; Attwood, P.V.
Investigation of the roles of allosteric domain arginine, aspartate, and glutamate residues of Rhizobium etli pyruvate carboxylase in relation to its activation by acetyl CoA
Biochemistry
55
4220-4228
2016
Rhizobium etli (Q2K340), Rhizobium etli, Rhizobium etli ATCC 51251 (Q2K340)
Westerhold, L.E.; Bridges, L.C.; Shaikh, S.R.; Zeczycki, T.N.
Kinetic and thermodynamic analysis of acetyl-CoA activation of Staphylococcus aureus pyruvate carboxylase
Biochemistry
56
3492-3506
2017
Staphylococcus aureus (A0A0H3JRU9), Staphylococcus aureus, Staphylococcus aureus ATCC 700699 (A0A0H3JRU9)
Choosangtong, K.; Sirithanakorn, C.; Adina-Zada, A.; Wallace, J.C.; Jitrapakdee, S.; Attwood, P.V.
Residues in the acetyl CoA binding site of pyruvate carboxylase involved in allosteric regulation
FEBS Lett.
589
2073-2079
2015
Rhizobium etli (Q2K340), Rhizobium etli, Rhizobium etli ATCC 51251 (Q2K340)
Gupta, S.; Sharma, A.; Kushwaha, H.; Shukla, P.
Over-expression of a Codon optimized yeast cytosolic pyruvate carboxylase (PYC2) in CHO cells for an augmented lactate metabolism
Front. Pharmacol.
8
463
2017
Saccharomyces cerevisiae
Sellers, K.; Fox, M.P.; Bousamra, M.; Slone, S.P.; Higashi, R.M.; Miller, D.M.; Wang, Y.; Yan, J.; Yuneva, M.O.; Deshpande, R.; Lane, A.N.; Fan, T.W.
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation
J. Clin. Invest.
125
687-698
2015
Homo sapiens (P11498), Homo sapiens
Lazar, N.; Fay, A.; Nandakumar, M.; Boyle, K.E.; Xavier, J.; Rhee, K.; Glickman, M.S.
Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal
Mol. Microbiol.
106
1018-1031
2017
Mycolicibacterium smegmatis (A0QV14), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0QV14)
Choi, P.; Jo, J.; Lin, Y.; Lin, M.; Chou, C.; Dietrich, L.; Tong, L.
A distinct holoenzyme organization for two-subunit pyruvate carboxylase
Nat. Commun.
7
12713
2016
Pseudomonas aeruginosa, Methylobacillus flagellatus (Q1H157), Methylobacillus flagellatus DSM 6875 (Q1H157)
Phannasil, P.; Thuwajit, C.; Warnnissorn, M.; Wallace, J.; MacDonald, M.; Jitrapakdee, S.
Pyruvate carboxylase is up-regulated in breast cancer and essential to support growth and invasion of MDA-MB-231 cells
PLoS ONE
10
e0129848
2015
Homo sapiens (P11498), Homo sapiens
Choi, P.H.; Vu, T.M.N.; Pham, H.T.; Woodward, J.J.; Turner, M.S.; Tong, L.
Structural and functional studies of pyruvate carboxylase regulation by cyclic di-AMP in lactic acid bacteria
Proc. Natl. Acad. Sci. USA
114
E7226-E7235
2017
Lactococcus lactis
Lasso, G.; Yu, L.P.; Gil, D.; Lazaro, M.; Tong, L.; Valle, M.
Functional conformations for pyruvate carboxylase during catalysis explored by cryoelectron microscopy
Structure
22
911-922
2014
Staphylococcus aureus (A0A0H3JRU9), Staphylococcus aureus, Staphylococcus aureus ATCC 700699 (A0A0H3JRU9)
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