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Information on EC 6.3.5.2 - GMP synthase (glutamine-hydrolysing) and Organism(s) Lacticaseibacillus rhamnosus and UniProt Accession O85192

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EC Tree
IUBMB Comments
Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia.
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Lacticaseibacillus rhamnosus
UNIPROT: O85192
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Word Map
The taxonomic range for the selected organisms is: Lacticaseibacillus rhamnosus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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Synonyms
glutamine amidotransferase, gmp synthetase, gmp synthase, gatase, guanosine monophosphate synthetase, xmp aminase, guanosine 5'-monophosphate synthetase, guanine monophosphate synthetase, pd0279, guanylate synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Glutamine amidotransferase
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GMP synthase
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GMP synthetase
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GMP synthetase (glutamine hydrolysing)
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GMPS
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Guanosine 5'-monophosphate synthetase
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Guanosine 5-monophosphate synthetase
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Guanosine monophosphate synthetase (glutamine-hydrolyzing)
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Guanylate synthetase
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Guanylate synthetase (glutamine-hydrolyzing)
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Synthetase, guanylate
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Xanthosine 5'-phosphate amidotransferase
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Xanthosine 5-monophosphate aminase
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Xanthosine-5'-phosphate-ammonia ligase
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Xanthosine-5'-phosphate:ammonia ligase (AMP-forming)
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Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
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XMP aminase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia.
CAS REGISTRY NUMBER
COMMENTARY hide
37318-71-1
not distinguished from EC 6.3.4.1
9023-55-6
EC 6.3.4.1
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GUAA_LACRH
517
0
57792
Swiss-Prot
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grimaldi, C.; Dutertre, M.; Simonet, J.M.
Genetic organization and polymorphism of the guaA gene encoding the GMP synthetase in Lactobacillus rhamnosus
Curr. Microbiol.
40
245-249
2000
Lacticaseibacillus rhamnosus (O85192), Lacticaseibacillus rhamnosus, Lacticaseibacillus rhamnosus X202 (O85192)
Manually annotated by BRENDA team