Information on EC 6.3.4.8 - imidazoleacetate-phosphoribosyldiphosphate ligase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

EC NUMBER
COMMENTARY hide
6.3.4.8
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RECOMMENDED NAME
GeneOntology No.
imidazoleacetate-phosphoribosyldiphosphate ligase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate = ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Histidine metabolism
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SYSTEMATIC NAME
IUBMB Comments
imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
37318-65-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate
?
show the reaction diagram
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-
-
-
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ATP + imidazoleacetic acid + 5-phosphoribosyl diphosphate
ADP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
show the reaction diagram
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-
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CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate
CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
show the reaction diagram
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-
-
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GTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate
GDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
show the reaction diagram
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate
?
show the reaction diagram
-
-
-
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0034
5-phosphoribosyl diphosphate
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-
0.218
ATP
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-
0.372
imidazoleacetate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2 - 9
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pH 7.2: about 50% of maximal activity, pH 9.0: about 25% of maximal activity
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
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labile at
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
phosphate stabilizes
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 0.001 M mercaptoethanol, 50% loss of activity after 1 week
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE