Information on EC 6.3.4.7 - ribose-5-phosphate-ammonia ligase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
6.3.4.7
-
RECOMMENDED NAME
GeneOntology No.
ribose-5-phosphate-ammonia ligase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Purine metabolism
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SYSTEMATIC NAME
IUBMB Comments
ribose-5-phosphate:ammonia ligase (ADP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9082-52-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Pigeon
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-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + ribose 5-phosphate + Asn
ADP + phosphate + 5-phosphoribosylamine + Asp
show the reaction diagram
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far less effective than NH4+
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-
-
ATP + ribose 5-phosphate + carbamoylphosphate
ADP + phosphate + 5-phosphoribosylamine + formate
show the reaction diagram
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-
-
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ATP + ribose 5-phosphate + Gln
ADP + phosphate + 5-phosphoribosylamine + Glu
show the reaction diagram
ATP + ribose 5-phosphate + NH4+
?
show the reaction diagram
ATP + ribose 5-phosphate + NH4+
ADP + phosphate + 5-phosphoribosylamine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + ribose 5-phosphate + NH4+
?
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3',5'-cAMP
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6-diazo-5-oxo-L-norleucine
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Methylthioinosine
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ribose 5-phosphate
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inhibition above 0.0125 M
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8
5-O-phosphono-D-ribofuranose
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6.3
NH4+
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
wild-type and mutant cell line deficient in phosphoribosyldiphosphate amidotransferase and phosphoribosyldiphosphate aminotransferase activities with normal activity of ribose-5-phosphate aminotransferase activities
Manually annotated by BRENDA team
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
-
5 min, inactivation
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-18°C, stable for several months
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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