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Information on EC 6.3.2.8 - UDP-N-acetylmuramate-L-alanine ligase and Organism(s) Thermotoga maritima and UniProt Accession Q9WY73

for references in articles please use BRENDA:EC6.3.2.8
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EC Tree
IUBMB Comments
Involved in the synthesis of a cell-wall peptide in bacteria.
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This record set is specific for:
Thermotoga maritima
UNIPROT: Q9WY73
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The taxonomic range for the selected organisms is: Thermotoga maritima
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
udp-n-acetylmuramate:l-alanine ligase, murc ligase, udp-n-acetylmuramate-l-alanine ligase, udp-n-acetylmuramoyl:l-alanine ligase, udp-n-acetylmuramic acid l-alanine ligase, udp-n-acetylmuramoyl-l-alanine synthetase, udp-n-acetylmuramyl:l-alanine ligase, udp-murnac:l-alanine ligase, l-alanine adding enzyme, uridine diphosphate n-acetylmuramate:l-alanine ligase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Alanine-adding enzyme
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L-Ala ligase
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L-Alanine adding enzyme
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Synthetase, uridine diphospho-N-acetylmuramoylalanine
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UDP-acetylmuramoyl-L-alanine synthetase
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UDP-MurNAc:L-alanine ligase
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UDP-N-acetylmuramate-alanine ligase
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UDP-N-acetylmuramoyl-L-alanine synthetase
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UDP-N-acetylmuramoylalanine synthetase
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UDP-N-acetylmuramyl:L-alanine ligase
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Uridine 5´-diphosphate-N-acetylmuramyl-L-alanine synthetase
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Uridine diphosphate N-acetylmuramate:L-alanine ligase
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Uridine diphospho-N-acetylmuramoylalanine synthetase
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Uridine-diphosphate-N-acetylmuramate:L-alanine ligase
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylic acid amide formation
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carboxamide formation
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
Involved in the synthesis of a cell-wall peptide in bacteria.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-52-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
show the reaction diagram
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-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + UDP-N-acetylmuramate + L-alanine
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
51740
calculated
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of TM0231 in Escherichia coli DL41
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Spraggon, G.; Schwarzenbacher, R.; Kreusch, A.; Lee, C.C.; Abdubek, P.; Ambing, E.; Biorac, T.; Brinen, L.S.; Canaves, J.M.; Cambell, J.; Chiu, H.J.; Dai, X.; Deacon, A.M.; DiDonato, M.; Elsliger, M.A.; Eshagi, S.; Floyd, R.; Godzik, A.et al.
Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC from Thermotoga maritima at 2.3.ANG. resolution
Proteins
55
1078-1081
2004
Thermotoga maritima (Q9WY73), Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9WY73)
Manually annotated by BRENDA team