Information on EC 6.3.2.42 - N-acetylaspartylglutamylglutamate synthase

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The expected taxonomic range for this enzyme is: Mus musculus

EC NUMBER
COMMENTARY hide
6.3.2.42
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RECOMMENDED NAME
GeneOntology No.
N-acetylaspartylglutamylglutamate synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Alanine, aspartate and glutamate metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
show the reaction diagram
ATP + N-acetyl-L-aspartate + L-glutamate
ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
show the reaction diagram
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
show the reaction diagram
Q6PFX8
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?
ATP + N-acetyl-L-aspartate + L-glutamate
ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
show the reaction diagram
Q6PFX8
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
highest expression levels in the brain stem and spinal cord, almost undetectable in the neocortex
Manually annotated by BRENDA team
; strong expression is restricted to deep cerebellar nuclei
Manually annotated by BRENDA team
; expression is found in the ventral and dorsal horns of gray matter in laminae III to X, but is low or absent in laminae I and II
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42000
x * 42000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 42000, SDS-PAGE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells; expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells. Because hexahistidine-tagged Escherichia coli-expressed enzyme using bacterial expressed protein