Information on EC 6.3.2.40 - cyclopeptine synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
6.3.2.40
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RECOMMENDED NAME
GeneOntology No.
cyclopeptine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4'-methoxyviridicatin biosynthesis
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viridicatin biosynthesis
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tryptophan metabolism
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine forming)
Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in the fungus Penicillium cyclopium. The enzyme is a non-ribosomal peptide synthase.