Information on EC 6.3.2.38 - N2-citryl-N6-acetyl-N6-hydroxylysine synthase

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The expected taxonomic range for this enzyme is: Enterobacteriaceae

EC NUMBER
COMMENTARY hide
6.3.2.38
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RECOMMENDED NAME
GeneOntology No.
N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aerobactin biosynthesis
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Lysine degradation
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation [5]. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citrate. This enzyme catalyses the first of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate [4,5].
CAS REGISTRY NUMBER
COMMENTARY hide
94047-30-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
show the reaction diagram
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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dependent on
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
N-ethylmaleimide
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p-chloromercuribenzoate
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE