Reference on EC 6.3.2.3 - glutathione synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Macnicol, P.K.
Homoglutathione and glutathione synthetases of legume seedlings: partial purification and substrate specificity
Plant Sci.
53
229-235
1987
Pisum sativum
-
Klapheck, S.; Latus, C.; Bergmann, L.
Localization of glutathione synthetase and distribution of glutathione in leaf cells of Pisum sativum L.
J. Plant Physiol.
131
123-131
1987
Pisum sativum
-
Kato, H.; Chihara, M.; Nishioka, T.; Murata, K.; Kimura, A.; Oda, J.
Homology of Escherichia coli B glutathione synthetase with dihydrofolate reductase in amino acid sequence and substrate binding site
J. Biochem.
101
207-215
1987
Escherichia coli, Escherichia coli B / ATCC 11303
Dennda, G.; Kula, M.R.
Purification and evaluation of the glutathione-synthesizing enzymes from Candida boidinii for cell-free synthesis of glutathione
J. Biotechnol.
4
143-158
1986
Brettanomyces abstinens, Saccharomyces cerevisiae, [Candida] boidinii, Pichia kudriavzevii, Cyberlindnera jadinii, Pichia membranifaciens, Ogataea angusta
-
Watanabe, K.; Yamano, Y.; Murata, K.; Kirmura, A.
Glutathione production by Escherichia coli cells with hybrid plasmid containing tandemly polymerized genes for glutathione synthetase
Appl. Microbiol. Biotechnol.
24
375-378
1986
Escherichia coli, Escherichia coli B / ATCC 11303
-
Law, M.Y.; Halliwell B.
Purification and properties of glutathione synthetase from spinach (Spinacia oleracea) leaves
Plant Sci.
43
185-191
1986
Spinacia oleracea
-
Meister, A.
Glutathione synthetase from rat kidney
Methods Enzymol.
113
393-399
1985
Rattus norvegicus
Gushima, H.; Miya, T.; Murata, K.; Kimura, A.
Purification and characterization of glutathione synthetase from Escherichia coli B
J. Appl. Biochem.
5
210-218
1983
Escherichia coli, Escherichia coli B / ATCC 11303
Murata, K.; Miya, T.; Gushima, H.; Kimura, A.
Cloning and amplification of a gene for glutathione synthetase in Escherichia coli B
Agric. Biol. Chem.
47
1381-1383
1983
Escherichia coli, Escherichia coli B / ATCC 11303
-
Oppenheimer, L.; Wellner, V.P.; Griffith, O.W.; Meister.A.
Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites
J. Biol. Chem.
254
5184-5190
1979
Rattus norvegicus
Sekura, R.; Hochreiter, M.; Meister, A.
alpha-Aminomethylglutarate, a beta-amino acid analog of glutamate that interacts with glutamine synthetase and the enzymes that catalyze glutathione synthesis
J. Biol. Chem.
251
2263-2270
1976
Ovis aries
Apontoweil, P.; Berends, W.
Glutathione biosynthesis in Escherichia coli K12. Properties of the enzymes and regulation
Biochim. Biophys. Acta
399
1-9
1975
Escherichia coli
Meister, A.
Glutathione synthesis
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
10
671-697
1974
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Pigeon
-
Wendel, A.; Schaich, E.; Weber, U.; Flohe, L.
Isolierung und Molekulargewichtsbestimmung der gamma-L-Glutamyl-L-cystein:Glycin-Ligase (EC 6.3.2.3)
Hoppe-Seyler's Z. Physiol. Chem.
353
514-522
1972
Bos taurus
Mooz, E.D.; Meister, A.
Glutathione biosynthesis. I. gamma-Glutamylcysteine synthetase (hog liver). II. Glutathione (tripeptide) synthetase (yeast)
Methods Enzymol.
17B
483-495
1971
Saccharomyces cerevisiae
-
Wang, C.L.; Oliver, D.J.
Cloning of the cDNA and genomic clones for glutathione synthetase from Arabidopsis thaliana and complementation of a gsh2 mutant in fission yeast
Plant Mol. Biol.
31
1093-1104
1996
Arabidopsis sp.
Ullmann, P.; Gondet, L.; Potier, S.; Bach, T.J.
Cloning of Arabidopsis thaliana glutathione synthetase (GSH2) by functional complementation of a yeast gsh2 mutant
Eur. J. Biochem.
236
662-669
1996
Arabidopsis sp.
Habenicht, A.; Hille, S.; Knochel, W.
Molecular cloning of the large subunit of glutathione synthetase from Xenopus laevis embryos
Biochim. Biophys. Acta
1174
295-298
1993
Xenopus laevis
Mutoh, N.; Nakagawa, C.W.; Ando, S.; Tanabe, K.; Hayashi, Y.
Cloning and sequencing of the gene encoding the large subunit of glutathione synthetase of Schizosaccharomyces pombe
Biochem. Biophys. Res. Commun.
181
430-436
1991
Saccharomyces pombe
Nardi, G.; Cipollaro, M.; Loguercio, C.
Assay of gamma-glutamylcysteine synthetase and glutathione synthetase in erythrocytes by high-performance liquid chromatography with fluorimetric detection
J. Chromatogr.
530
122-128
1990
Homo sapiens
Wang, C.L.; Oliver, D.J.
Identification of a putative flexibel loop in Arabidopsis glutathione synthetase
Biochem. J.
322
241-244
1997
Arabidopsis sp., Escherichia coli
Wang, C.L.; Oliver, D.J.
Glutathione synthetase: similarities of the protein from Schizosaccharomyces pombe and Arabidopsis thaliana
Biochem. J.
326
563-566
1997
Arabidopsis sp., Schizosaccharomyces pombe
Nakagawa, C.W.; Mutoh, N.; Hayashi, Y.
Glutathione synthetase from the fission yeast. Purification and its unique heteromeric subunit structure
Biochem. Cell Biol.
71
447-453
1993
Schizosaccharomyces pombe
Tanaka, T.; Nishioka, T.; Oda, J.
Nicked multifunctional loop of glutathione synthetase still protects the catalytic intermediate
Arch. Biochem. Biophys.
339
151-156
1997
Escherichia coli
Hara, T.; Tanaka, T.; Kato, H.; Nishioka, T.; Oda, J.
Site-directed mutagenesis of glutathione synthetase from Escherichia coli B: mapping of the gamma-glutamyl-L-cysteine-binding site
Protein Eng.
8
711-716
1995
Escherichia coli, Escherichia coli B / ATCC 11303
Matsuda, K.; Mizuguchi, K.; Nishgioka, T.; Kato, H.; Go, N.; Oda, J.
Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins
Protein Eng.
9
1083-1092
1996
Escherichia coli, Escherichia coli B / ATCC 11303
Gali, R.R.; Board, P.G.
Identification of an essential cysteine residue in human glutathione synthase
Biochem. J.
321
207-210
1997
Homo sapiens
Fan, C.; Moews, P.C.; Shi, Y.; Walsh, C.T.; Knox, J.R.
A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:D-alanine ligase of Escherichia coli
Proc. Natl. Acad. Sci. USA
92
1172-1176
1995
Escherichia coli
Huang, C.S.; He, W.; Meister, A.; Anderson, M.E.
Amino acid sequence of rat kidney glutathione synthetase
Proc. Natl. Acad. Sci. USA
92
1232-1236
1995
Rattus norvegicus
Sun, Y.
Induction of glutathione synthetase by 1,10-phenanthroline
FEBS Lett.
408
16-20
1997
Mus musculus
Kato, H.; Tanaka, T.; Nishioka, T.; Kimura, A.; Oda, J.
Role of cysteine residues in glutathione synthetase from Escherichia coli B
J. Biol. Chem.
263
11646-11651
1988
Escherichia coli
Yamaguchi, H.; Kato, H.; Hata, Y.; Nishioka, T.; Kimura, A.; Oda, J.; Katsube, Y.
Three-dimensional structure of the glutathione synthetase from Escherichia coli B at 2.0 A resolution
J. Mol. Biol.
229
1083-1100
1993
Escherichia coli, Escherichia coli B / ATCC 11303
Hibi, T.; Kato, H.; Nishioka, T.; Oda, J.; Yamaguchi, H.; Katsube, Y.; Tanizawa, K.; Fukui, T.
Use of adenosine(5)poylphospho(5)pyridoxals to study the substrate-binding region of glutathione synthetase from Escherichia coli B
Biochemistry
32
1548-1554
1993
Escherichia coli, Escherichia coli B / ATCC 11303
Tanaka, T.; Yamaguchi, H.; Kato, H.; Nishioka, T.; Katsube, Y.; Oda, J.
Flexibility impaired by mutations related the multifunctional roles of the loop in glutathione synthetase
Biochemistry
32
12398-12404
1993
Escherichia coli
Kato, H.; Tanaka, T.; Yamaguchi, H.; Hara, T.; Nishioka, T.; Katsube, Y.; Oda, J.
Flexible loop that is novel catalytic machinery in a ligase. Atomic structure and function of the loopless glutathione synthetase
Biochemistry
33
4995-4999
1994
Escherichia coli, Escherichia coli B / ATCC 11303
Tanaka, T.; Kato, H.; Nishioka, T.; Oda, J.
Mutational and proteolytic studies on a flexible loop in glutathione synthetase from Escherichia coli B: the loop and arginine 233 are critical for the catalytic reaction
Biochemistry
31
2259-2265
1992
Escherichia coli, Escherichia coli B / ATCC 11303
Hara, T.; Kato, H.; Katsube, Y.; Oda, J.
A pseudo-Michaelis quarternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution
Biochemistry
35
11967-11974
1996
Escherichia coli (P04425), Escherichia coli
Cornell, J.S.; Meister, A.
Glutathione and gamma-glutamyl cycle enzymes in crypt and villus tip cells of rat jejunal mucosa
Proc. Natl. Acad. Sci. USA
73
420-422
1976
Rattus norvegicus
Wendel, A.; Flohe, L.
Kinetische Versuche zum Reaktionsmechanismus der Glutathion-synthetase (EC 6.3.2.3)
Hoppe-Seyler's Z. Physiol. Chem.
353
523-530
1972
Bos taurus
Gali, R.R.; Board, P.G.
Sequencing and expression of a cDNA for human glutathione synthetase
Biochem. J.
310
353-358
1995
Homo sapiens
Frendo, P.; Jimenez, M.J.; Mathieu, C.; Duret, L.; Gallesi, D.; Van de Sype, G.; Herouart, D.; Puppo, A.
A Medicago truncatula homoglutathione synthetase is derived from glutathione synthetase by gene duplication
Plant Physiol.
126
1706-1715
2001
Medicago truncatula (Q94GA0), Medicago truncatula
Moran, J.F.; Iturbe-Ormaetxe, I.; Matamoros, M.A.; Rubio, M.C.; Clemente, M.R.; Brewin, N.J.; Becana, M.
Glutathione and homoglutathione synthetases of legume nodules. Cloning, expression, and subcellular localization
Plant Physiol.
124
1381-1392
2000
Vigna unguiculata, Phaseolus vulgaris (Q9FV26), Pisum sativum (Q9FV27), Pisum sativum (Q9FVA2)
Luo, J.L.; Huang, C.S.; Babaoglu, K.; Anderson, M.E.
Novel kinetics of mammalian glutathione synthetase: characterization of gamma-glutamyl substrate cooperative binding
Biochem. Biophys. Res. Commun.
275
577-581
2000
Rattus norvegicus
Njalsson, R.; Norgren, S.; Larsson, A.; Huang, C.S.; Anderson, M.E.; Luo, J.L.
Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase
Biochem. Biophys. Res. Commun.
289
80-84
2001
Homo sapiens
Huang, Z.A.; Yang, H.; Chen, C.; Zeng, Z.; Lu, S.C.
Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression
Biochim. Biophys. Acta
1493
48-55
2000
Homo sapiens, Rattus norvegicus
Volohonsky, G.; Tuby, C.N.; Porat, N.; Wellman-Rousseau, M.; Visvikis, A.; Leroy, P.; Rashi, S.; Steinberg, P.; Stark, A.A.
A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells
Chem. Biol. Interact.
140
49-65
2002
Rattus norvegicus
Kim, S.J.; Shin, Y.H.; Kim, K.; Park, E.H.; Sa, J.H.; Lim, C.J.
Regulation of the gene encoding glutathione synthetase from the fission yeast
J. Biochem. Mol. Biol.
36
326-331
2003
Schizosaccharomyces pombe
Yang, H.; Zeng, Y.; Lee, T.D.; Yang, Y.; Ou, X.; Chen, L.; Haque, M.; Rippe, R.; Lu, S.C.
Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone
J. Biol. Chem.
277
35232-35239
2002
Rattus norvegicus (AF333982)
Phlippen, N.; Hoffmann, K.; Fischer, R.; Wolf, K.; Zimmermann, M.
The glutathione synthetase of Schizosaccharomyces pombe is synthesized as a homodimer but retains full activity when present as a heterotetramer
J. Biol. Chem.
278
40152-40161
2003
Schizosaccharomyces pombe
Dinescu, A.; Cundari, T.R.; Bhansali, V.S.; Luo, J.L.; Anderson, M.E.
Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes
J. Biol. Chem.
279
22412-22421
2004
Homo sapiens (P48637), Homo sapiens
Tchantchou, F.; Graves, M.; Ashline, D.; Morin, A.; Pimenta, A.; Ortiz, D.; Rogers, E.; Shea, T.B.
Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E
J. Neurosci. Res.
75
508-515
2004
Mus musculus
Zhu, Y.L.; Pilon-Smits, E.A.H.; Jouanin, L.; Terry, N.
Overexpression of glutathione synthetase in Indian mustard enhances cadmium accumulation and tolerance
Plant Physiol.
119
73-79
1999
Brassica juncea, Escherichia coli
Gogos, A.; Shapiro, L.
Large conformational changes in the catalytic cycle of glutathione synthase
Structure
10
1669-1676
2002
Saccharomyces cerevisiae (Q08220), Saccharomyces cerevisiae
Njalsson, R.; Carlsson, K.; Bhansali, V.; Luo, J.L.; Nilsson, L.; Ladenstein, R.; Anderson, M.; Larsson, A.; Norgren, S.
Human hereditary glutathione synthetase deficiency: kinetic properties of mutant enzymes
Biochem. J.
381
489-494
2004
Homo sapiens (P48637), Homo sapiens
Lee, T.D.; Yang, H.; Whang, J.; Lu, S.C.
Cloning and characterization of the human glutathione synthetase 5'-flanking region
Biochem. J.
390
521-528
2005
Homo sapiens (P48637), Homo sapiens
Skipsey, M.; Davis, B.G.; Edwards, R.
Diversification in substrate usage by glutathione synthetases from soya bean (Glycine max), wheat (Triticum aestivum) and maize (Zea mays)
Biochem. J.
391
567-574
2005
Triticum aestivum (Q7X9G0), Triticum aestivum (Q7X9G1), Zea mays (Q7XB40), Glycine max (Q9M426)
Gupta, S.; Srivastava, A.K.; Banu, N.
Setaria cervi: kinetic studies of filarial glutathione synthetase by high performance liquid chromatography
Exp. Parasitol.
111
137-141
2005
Setaria cervi
Jez, J.M.; Cahoon, R.E.
Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana
J. Biol. Chem.
279
42726-42731
2004
Arabidopsis thaliana (P46416), Arabidopsis thaliana
Janowiak, B.E.; Griffith, O.W.
Glutathione synthesis in Streptococcus agalactiae. One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities
J. Biol. Chem.
280
11829-11839
2005
Streptococcus agalactiae
Vergauwen, B.; De Vos, D.; Van Beeumen, J.J.
Characterization of the bifunctional gamma -glutamate-cysteine ligase-glutathione synthetase (GshF) of Pasteurella multocida
J. Biol. Chem.
281
4380-4394
2005
Pasteurella multocida
Gomez, L.D.; Vanacker, H.; Buchner, P.; Noctor, G.; Foyer, C.H.
Intercellular distribution of glutathione synthesis in maize leaves and its response to short-term chilling
Plant Physiol.
134
1662-1671
2004
Zea mays (Q8W4W2), Zea mays
Kino, K.; Kuratsu, S.; Noguchi, A.; Kokubo, M.; Nakazawa, Y.; Arai, T.; Yagasaki, M.; Kirimura, K.
Novel substrate specificity of glutathione synthesis enzymes from Streptococcus agalactiae and Clostridium acetobutylicum
Biochem. Biophys. Res. Commun.
352
351-359
2007
Clostridium acetobutylicum, Streptococcus agalactiae (Q8DXM9), Streptococcus agalactiae, Streptococcus agalactiae 2603 V/R (Q8DXM9), Clostridium acetobutylicum NBRC13948
Dinescu, A.; Anderson, M.E.; Cundari, T.R.
Catalytic loop motion in human glutathione synthetase: A molecular modeling approach
Biochem. Biophys. Res. Commun.
353
450-456
2007
Homo sapiens
Janowiak, B.E.; Hayward, M.A.; Peterson, F.C.; Volkman, B.F.; Griffith, O.W.
gamma-Glutamylcysteine synthetase-glutathione synthetase: domain structure and identification of residues important in substrate and glutathione binding
Biochemistry
45
10461-10473
2006
Streptococcus agalactiae
Allen, T.C.; Granville, L.A.; Cagle, P.T.; Haque, A.; Zander, D.S.; Barrios, R.
Expression of glutathione S-transferase pi and glutathione synthase correlates with survival in early stage non-small cell carcinomas of the lung
Hum. Pathol.
38
220-227
2007
Homo sapiens
Herrera, K.; Cahoon, R.E.; Kumaran, S.; Jez, J.
Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues
J. Biol. Chem.
282
17157-17165
2007
Arabidopsis thaliana (P46416), Arabidopsis thaliana
Muglia, C.I.; Grasso, D.H.; Aguilar, O.M.
Rhizobium tropici response to acidity involves activation of glutathione synthesis
Microbiology
153
1286-1296
2007
Rhizobium tropici, Rhizobium tropici CIAT899
Borras-Hidalgo, O.; Thomma, B.P.; Collazo, C.; Chacon, O.; Borroto, C.J.; Ayra, C.; Portieles, R.; Lopez, Y.; Pujol, M.
EIL2 transcription factor and glutathione synthetase are required for defense of tobacco against tobacco blue mold
Mol. Plant Microbe Interact.
19
399-406
2006
Nicotiana megalosiphon
Stevenson, D.J.; Morgan, C.; McLellan, L.I.; Helen Grant, M.
Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures
Toxicol. In Vitro
21
527-532
2007
Rattus norvegicus
Ren, J.; Privratsky, J.R.; Yang, X.; Dong, F.; Carlson, E.C.
Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts
Crit. Care Med.
36
2106-2116
2008
Mus musculus
Du, T.; Ciccotosto, G.D.; Cranston, G.A.; Kocak, G.; Masters, C.L.; Crouch, P.J.; Cappai, R.; White, A.R.
Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation
Free Radic. Biol. Med.
44
44-55
2008
Mus musculus
Bahia, P.K.; Rattray, M.; Williams, R.J.
Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes
J. Neurochem.
106
2194-2204
2008
Mus musculus
Lu, S.C.
Regulation of glutathione synthesis
Mol. Aspects Med.
30
42-59
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Pasternak, M.; Lim, B.; Wirtz, M.; Hell, R.; Cobbett, C.S.; Meyer, A.J.
Restricting glutathione biosynthesis to the cytosol is sufficient for normal plant development
Plant J.
53
999-1012
2008
Arabidopsis thaliana (P46416)
Nishiya, T.; Mori, K.; Hattori, C.; Kai, K.; Kataoka, H.; Masubuchi, N.; Jindo, T.; Manabe, S.
The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats
Toxicol. Appl. Pharmacol.
232
280-291
2008
Rattus norvegicus (P46413)
Muniz Ortiz, J.G.; Opoka, R.; Kane, D.; Cartwright, I.L.
Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase
Toxicol. Sci.
107
416-426
2008
Drosophila melanogaster
Jackson, R.M.; Gupta, C.
Hypoxia and kinase activity regulate lung epithelial cell glutathione
Exp. Lung Res.
36
45-56
2010
Homo sapiens
Cruz de Carvalho, M.H.; Brunet, J.; Bazin, J.; Kranner, I.; d Arcy-Lameta, A.; Zuily-Fodil, Y.; Contour-Ansel, D.
Homoglutathione synthetase and glutathione synthetase in drought-stressed cowpea leaves: expression patterns and accumulation of low-molecular-weight thiols
J. Plant Physiol.
167
480-487
2010
Vigna unguiculata
Fyfe, P.K.; Alphey, M.S.; Hunter, W.N.
Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme
Mol. Biochem. Parasitol.
170
93-99
2010
Trypanosoma brucei
Uchida, M.; Sugaya, M.; Kanamaru, T.; Hisatomi, H.
Alternative RNA splicing in expression of the glutathione synthetase gene in human cells
Mol. Biol. Rep.
37
2105-2109
2010
Homo sapiens (P48637), Homo sapiens
Liedschulte, V.; Wachter, A.; Zhigang, A.; Rausch, T.
Exploiting plants for glutathione (GSH) production: Uncoupling GSH synthesis from cellular controls results in unprecedented GSH accumulation
Plant Biotechnol. J.
8
1-14
2010
Streptococcus thermophilus (D7P1H2)
Dinescu, A.; Brown, T.R.; Barelier, S.; Cundari, T.R.; Anderson, M.E.
The role of the glycine triad in human glutathione synthetase
Biochem. Biophys. Res. Commun.
400
511-516
2010
Homo sapiens
Slavens, K.D.; Brown, T.R.; Barakat, K.A.; Cundari, T.R.; Anderson, M.E.
Valine 44 and valine 45 of human glutathione synthetase are key for subunit stability and negative cooperativity
Biochem. Biophys. Res. Commun.
410
597-601
2011
Homo sapiens
Li, W.; Li, Z.; Yang, J.; Ye, Q.
Production of glutathione using a bifunctional enzyme encoded by gshF from Streptococcus thermophilus expressed in Escherichia coli
J. Biotechnol.
154
261-268
2011
Streptococcus thermophilus (D4N891), Streptococcus thermophilus SIIM B218 (D4N891)
Sharma, S.K.; Banyal, H.S.
Characterization of Plasmodium berghei glutathione synthetase
Parasitol. Int.
60
321-323
2011
Plasmodium berghei
Cameron, J.C.; Pakrasi, H.B.
Essential role of glutathione in acclimation to environmental and redox perturbations in the cyanobacterium Synechocystis sp. PCC 6803
Plant Physiol.
154
1672-1685
2010
Synechocystis sp. (P73493), Synechocystis sp.
Brown, T.R.; Drummond, M.L.; Barelier, S.; Crutchfield, A.S.; Dinescu, A.; Slavens, K.D.; Cundari, T.R.; Anderson, M.E.
Aspartate 458 of human glutathione synthetase is important for cooperativity and active site structure
Biochem. Biophys. Res. Commun.
411
536-542
2011
Homo sapiens (P48637), Homo sapiens
Musgrave, W.B.; Yi, H.; Kline, D.; Cameron, J.C.; Wignes, J.; Dey, S.; Pakrasi, H.B.; Jez, J.M.
Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote
Biochem. J.
450
63-72
2013
Synechocystis sp. (P73493), Synechocystis sp.
Merlino, A.; Russo Krauss, I.; Albino, A.; Pica, A.; Vergara, A.; Masullo, M.; De Vendittis, E.; Sica, F.
Improving protein crystal quality by the without-oil microbatch method: crystallization and preliminary X-ray diffraction analysis of glutathione synthetase from Pseudoalteromonas haloplanktis
Int. J. Mol. Sci.
12
6312-6319
2011
Pseudoalteromonas haloplanktis
Albino, A.; Marco, S.; Di Maro, A.; Chambery, A.; Masullo, M.; De Vendittis, E.
Characterization of a cold-adapted glutathione synthetase from the psychrophile Pseudoalteromonas haloplanktis
Mol. Biosyst.
8
2405-2414
2012
Pseudoalteromonas haloplanktis (Q3IFA2), Pseudoalteromonas haloplanktis, Pseudoalteromonas haloplanktis TAC 125 (Q3IFA2)
Dworeck, T.; Zimmermann, M.
Site directed mutagenesis of Schizosaccharomyces pombe glutathione synthetase produces an enzyme with homoglutathione synthetase activity
PLoS ONE
7
e46580
2012
Schizosaccharomyces pombe (P35669), Schizosaccharomyces pombe
Grabek-Lejko, D.; Kurylenko, O.O.; Sibirny, V.A.; Ubiyvovk, V.M.; Penninckx, M.; Sibirny, A.A.
Alcoholic fermentation by wild-type Hansenula polymorpha and Saccharomyces cerevisiae versus recombinant strains with an elevated level of intracellular glutathione
J. Ind. Microbiol. Biotechnol.
38
1853-1859
2011
Ogataea angusta (A0A067XH95)
Jiang, Y.; Tao, R.; Shen, Z.; Sun, L.; Zhu, F.; Yang, S.
Enzymatic production of glutathione by bifunctional gamma-glutamylcysteine synthetase/glutathione synthetase coupled with in vitro acetate kinase-based ATP generation
Appl. Biochem. Biotechnol.
180
1446-1455
2016
Streptococcus thermophilus (D4N891), Streptococcus thermophilus, Streptococcus agalactiae serogroup V (Q8DXM9), Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R (Q8DXM9), Streptococcus thermophilus SIIM B218 (D4N891)
Yang, J.; Li, W.; Wang, D.; Wu, H.; Li, Z.; Ye, Q.
Characterization of bifunctional L-glutathione synthetases from Actinobacillus pleuropneumoniae and Actinobacillus succinogenes for efficient glutathione biosynthesis
Appl. Microbiol. Biotechnol.
100
6279-6289
2016
Actinobacillus succinogenes (A6VQP8), Actinobacillus pleuropneumoniae (D4N892), Actinobacillus pleuropneumoniae ATCC 55618 (D4N892)
Qiu, Z.; Deng, Z.; Tan, H.; Zhou, S.; Cao, L.
Engineering the robustness of Saccharomyces cerevisiae by introducing bifunctional glutathione synthase gene
J. Ind. Microbiol. Biotechnol.
42
537-542
2015
Streptococcus thermophilus (D7P1H2)
Wang, D.; Wang, C.; Wu, H.; Li, Z.; Ye, Q.
Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase
J. Ind. Microbiol. Biotechnol.
43
45-53
2016
Streptococcus thermophilus (D4N891), Streptococcus thermophilus SIIM B218 (D4N891)
Qiu, Z.; Tan, H.; Zhou, S.; Cao, L.
Surface display of a bifunctional glutathione synthetase on Saccharomyces cerevisiae for converting chicken feather hydrolysate into glutathione
Mol. Biotechnol.
56
726-730
2014
Streptococcus thermophilus (D7P1H2)
Kong, M.; Wang, F.; Tian, L.; Tang, H.; Zhang, L.
Functional identification of glutamate cysteine ligase and glutathione synthetase in the marine yeast Rhodosporidium diobovatum
Naturwissenschaften
105
doi: 10.1007/s00114-017-1520-2
2017
Rhodotorula diobovata (A0A0U3DG08), Rhodotorula diobovata, Rhodotorula diobovata MCCC 2A00023 (A0A0U3DG08)
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