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Reference on EC 6.3.2.26 - N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kallow, W.; Neuhof, T.; Arezi, B.; Jungblut, P.; von Doehren, H.
Penicillin biosynthesis: intermediates of biosynthesis of delta-L-alpha-aminoadipyl-L-cysteinyl-D-valine formed by ACV synthetase from Acremonium chrysogenum
FEBS Lett.
414
74-78
1997
Acremonium chrysogenum
Manually annotated by BRENDA team
Kallow, W.; Von Dohren, H.; Kleinkauf, H.
Penicillin biosynthesis: energy requirement for tripeptide precursor formation by delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Acremonium chrysogenum
Biochemistry
37
5947-5952
1998
Acremonium chrysogenum
Manually annotated by BRENDA team
MacCabe, A.P.; Van Liempt, H.; Palissa, H.; Unkles, S.E.; Riach, M.B.R.; Pfeifer, E.; Von Doehren, H.; Kinghorn, J.R.
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway
J. Biol. Chem.
266
12646-12654
1991
BRENDA: Aspergillus nidulans
Textmining: Petroselinum crispum, Areas
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Banko, G.; Demain, A.L.; Wolfe, S.
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase (ACV synthetase): a multifunctional enzyme with broad substrate specificity for the synthesis of penicillin and cephalosporin precursors
J. Am. Chem. Soc.
109
2858-2860
1987
Acremonium chrysogenum
-
Manually annotated by BRENDA team
Baldwin, J.E.; Shiau, C.Y.; Byford, M.F.; Schofield, C.J.
Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products
Biochem. J.
301
367-372
1994
Acremonium chrysogenum, Streptomyces clavuligerus
-
Manually annotated by BRENDA team
Zhang, J.; Demain, A.L.
Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites
Arch. Microbiol.
158
364-369
1992
Acremonium chrysogenum, Streptomyces clavuligerus
-
Manually annotated by BRENDA team
Shiau, C.Y.; Byford, M.F.; Baldwin, J.E.; Schofield, C.J.
Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase
Biochem. Soc. Trans.
23
629S
1995
Acremonium chrysogenum
Manually annotated by BRENDA team
Shiau, C.Y.; Byford, M.F.; Aplin, R.T.; Baldwin, J.E.; Schofield, C.J.
L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation
Biochemistry
36
8798-8806
1997
Acremonium chrysogenum
Manually annotated by BRENDA team
Zhang, J.; Wolfe, S.; Demain, A.L.
Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus
Biochem. J.
283
691-698
1992
Streptomyces clavuligerus
Manually annotated by BRENDA team
Coque, J.J.R.; De la Fuente, J.L.; Liras, P.; Martin, J.F.
Overexpression of the Nocardia lactamdurans alpha-aminoadipyl-cysteinyl-valine synthetase in Streptomyces lividans. The purified multienzyme uses cystathionine and 6-oxopiperidine 2-carboxylate as substrates for synthesis of the tripeptide
Eur. J. Biochem.
242
264-270
1996
Amycolatopsis lactamdurans
Manually annotated by BRENDA team
Zhang, J.; Demain, A.L.
In vitro stabilization of ACV synthetase activity from Streptomyces clavuligerus
Appl. Biochem. Biotechnol.
37
97-110
1992
Streptomyces clavuligerus
-
Manually annotated by BRENDA team
Theilgaard, H.B.A.; Kristiansen, K.N.; Henriksen, C.M.; Nielsen, J.
Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum
Biochem. J.
327
185-191
1997
Penicillium chrysogenum
-
Manually annotated by BRENDA team
Aharonowitz, Y.; Bergmeyer, J.; Cantoral, J.M.; Cohen, G.; Demain, A.L.; Fink, U.; Kinghorn, J.; Kleinkauf, H.; MacCabe, A.; et al.
delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase, the multienzyme integrating the four primary reactions in b-lactam biosynthesis, as a model peptide synthetase
Bio/Technology
11
807-810
1993
Acremonium chrysogenum, Acremonium persicinum, Amycolatopsis lactamdurans, Aspergillus nidulans, Lysobacter lactamgenus, Penicillium chrysogenum
Manually annotated by BRENDA team
Byford, M.F.; Baldwin, J.E.; Shiau, C.Y.; Schofield, C.J.
The mechanism of ACV synthetase
Chem. Rev.
97
2631-2649
1997
Acremonium chrysogenum, Aspergillus nidulans, Penicillium chrysogenum, Streptomyces clavuligerus
Manually annotated by BRENDA team
Aidoo, K.A.; Wong, A.; Alexander, D.C.; Rittamer, R.A.R.; Jensen, S.E.
Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis
Gene
147
41-46
1994
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Liras, P.; Demain, A.L.
Enzymology of beta-lactam compounds with cephem structure produced by actinomycete
Methods Enzymol.
458
401-429
2009
Actinomyces sp.
Manually annotated by BRENDA team
Yokooji, Y.; Tomita, H.; Atomi, H.; Imanaka, T.
Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the archaea
J. Biol. Chem.
284
28137-28145
2009
Archaea
Automatic Mining of ENzyme DAta
Siewers, V.; Chen, X.; Huang, L.; Zhang, J.; Nielsen, J.
Heterologous production of non-ribosomal peptide LLD-ACV in Saccharomyces cerevisiae
Metab. Eng.
11
391-397
2009
BRENDA: Penicillium chrysogenum
Textmining: Saccharomyces cerevisiae, Bacillus subtilis, Aspergillus nidulans
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Gidijala, L.; Kiel, J.A.; Douma, R.D.; Seifar, R.M.; van Gulik, W.M.; Bovenberg, R.A.; Veenhuis, M.; van der Klei, I.J.
An engineered yeast efficiently secreting penicillin
PLoS ONE
4
e8317
2009
BRENDA: Penicillium chrysogenum
Textmining: Bacillus subtilis, Halopteris polymorpha
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Tomita, H.; Yokooji, Y.; Ishibashi, T.; Imanaka, T.; Atomi, H.
Biochemical characterization of pantoate kinase, a novel enzyme necessary for coenzyme A biosynthesis in the Archaea
J. Bacteriol.
194
5434-5443
2012
Thermococcus kodakarensis, Thermococcus kodakarensis (Q5JHF1), archaeon
Automatic Mining of ENzyme DAta
Katoh, H.; Tamaki, H.; Tokutake, Y.; Hanada, S.; Chohnan, S.
Identification of pantoate kinase and phosphopantothenate synthetase from Methanospirillum hungatei
J. Biosci. Bioeng.
115
372-376
2013
Methanospirillum hungatei, Methanospirillum hungatei (Q2FUB2), Methanospirillum hungatei (Q2FUA9), Thermococcus kodakarensis
Automatic Mining of ENzyme DAta
Fernandez-Aguado, M.; Teijeira, F.; Martin, J.F.; Ullan, R.V.
A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum
Appl. Microbiol. Biotechnol.
97
795-808
2013
Penicillium chrysogenum (B6HLU1), Penicillium chrysogenum, Penicillium chrysogenum Wisconsin 54-1255 (B6HLU1)
Manually annotated by BRENDA team
Wu, X.; Garcia-Estrada, C.; Vaca, I.; Martin, J.F.
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
Biochimie
94
354-364
2012
Penicillium chrysogenum (B6HLU1), Penicillium chrysogenum, Penicillium chrysogenum Wisconsin 54-1255 (B6HLU1)
Manually annotated by BRENDA team
Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H.
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea
Extremophiles
16
819-828
2012
BRENDA: Thermococcus kodakarensis (Q5JIZ8), Thermococcus kodakarensis
Textmining: Archaea, archaeon
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Suring, W.; Marien, J.; Broekman, R.; van Straalen, N.M.; Roelofs, D.
Biochemical pathways supporting beta-lactam biosynthesis in the springtail Folsomia candida
Biol. Open
5
1784-1789
2016
Folsomia candida
Manually annotated by BRENDA team
Kishimoto, A.; Kita, A.; Ishibashi, T.; Tomita, H.; Yokooji, Y.; Imanaka, T.; Atomi, H.; Miki, K.
Crystal structure of phosphopantothenate synthetase from Thermococcus kodakarensis
Proteins
82
1924-1936
2014
Thermococcus, Archaea
Automatic Mining of ENzyme DAta
Kita, A.; Kishimoto, A.; Shimosaka, T.; Tomita, H.; Yokooji, Y.; Imanaka, T.; Atomi, H.; Miki, K.
Crystal structure of pantoate kinase from Thermococcus kodakarensis
Proteins
88
718-724
2020
Archaea
Automatic Mining of ENzyme DAta
Gutiérrez, S; Díez, B; Montenegro, E; Martín, JF
Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains.
J Bacteriol
173
2354-65
1991
Brevibacillus brevis, Penicillium chrysogenum, Acremonium
Automatic Mining of ENzyme DAta
Baldwin, JE; Bird, JW; Field, RA; O'Callaghan, NM; Schofield, CJ; Willis, AC
Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase.
J Antibiot (Tokyo)
44
241-8
1991
Streptomyces clavuligerus, Acremonium chrysogenum, Acremonium
Automatic Mining of ENzyme DAta
Smith, DJ; Earl, AJ; Turner, G
The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases.
EMBO J
9
2743-50
1990
Penicillium chrysogenum
Automatic Mining of ENzyme DAta
van Liempt, H; von Döhren, H; Kleinkauf, H
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. The first enzyme in penicillin biosynthesis is a multifunctional peptide synthetase.
J Biol Chem
264
3680-4
1989
Aspergillus nidulans
Automatic Mining of ENzyme DAta
Schwecke, T; Aharonowitz, Y; Palissa, H; von Döhren, H; Kleinkauf, H; van Liempt, H
Enzymatic characterisation of the multifunctional enzyme delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.
Eur J Biochem
205
687-94
1992
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Tobin, MB; Kovacevic, S; Madduri, K; Hoskins, JA; Skatrud, PL; Vining, LC; Stuttard, C; Miller, JR
Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli.
J Bacteriol
173
6223-9
1991
Escherichia coli, Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Hoskins, JA; O'Callaghan, N; Queener, SW; Cantwell, CA; Wood, JS; Chen, VJ; Skatrud, PL
Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremonium.
Curr Genet
18
523-30
1990
Acremonium chrysogenum, Brevibacillus brevis
Automatic Mining of ENzyme DAta
Baldwin, JE; Bird, JW; Field, RA; O'Callaghan, NM; Schofield, CJ
Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus.
J Antibiot (Tokyo)
43
1055-7
1990
Streptomyces clavuligerus, Acremonium chrysogenum
Automatic Mining of ENzyme DAta
Jensen, SE; Wong, A; Rollins, MJ; Westlake, DW
Purification and partial characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.
J Bacteriol
172
7269-71
1990
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Jhang, J; Wolfe, S; Demain, AL
Phosphate regulation of ACV synthetase and cephalosporin biosynthesis in Streptomyces clavuligerus.
FEMS Microbiol Lett
48
145-50
1989
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
White, RL; DeMarco, AC; Shapiro, S; Vining, LC; Wolfe, S
Measurement of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity in Streptomyces clavuligerus by high-performance liquid chromatography after precolumn derivatization with o-phthaldialdehyde.
Anal Biochem
178
399-403
1989
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Zhang, JY; Wolfe, S; Demain, AL
Effect of ammonium as nitrogen source on production of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase by Cephalosporium acremonium C-10.
J Antibiot (Tokyo)
40
1746-50
1987
Acremonium chrysogenum
Automatic Mining of ENzyme DAta
Yu, H; Serpe, E; Romero, J; Coque, JJ; Maeda, K; Oelgeschläger, M; Hintermann, G; Liras, P; Martín, JF; Demain, AL
Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.
Microbiology
140 ( Pt 12)
3367-77
1994
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Baldwin, JE; Shiau, CY; Byford, MF; Schofield, CJ
Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products.
Biochem J
301 ( Pt 2)
367-72
1994
Acremonium chrysogenum
Automatic Mining of ENzyme DAta
Kennedy, J; Turner, G
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans.
Mol Gen Genet
253
189-97
1996
Aspergillus nidulans
Automatic Mining of ENzyme DAta
Etchegaray, A; Dieckmann, R; Kennedy, J; Turner, G; von Döhren, H
ACV synthetase: expression of amino acid activating domains of the Penicillium chrysogenum enzyme in Aspergillus nidulans.
Biochem Biophys Res Commun
237
166-9
1997
Penicillium chrysogenum, Aspergillus nidulans
Automatic Mining of ENzyme DAta
Theilgaard, HB; Kristiansen, KN; Henriksen, CM; Nielsen, J
Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum.
Biochem J
327 ( Pt 1)
185-91
1997
Penicillium chrysogenum
Automatic Mining of ENzyme DAta
Kim, MK; An, YJ; Cha, SS
The crystal structure of a novel phosphopantothenate synthetase from the hyperthermophilic archaea, Thermococcus onnurineus NA1.
Biochem Biophys Res Commun
439
533-538
2013
Archaea, Thermococcus onnurineus NA1, Bacteria, Methanosarcina mazei, eukaryota, Thermococcus kodakarensis
Automatic Mining of ENzyme DAta
van de Kamp, M; Driessen, AJ; Konings, WN
Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi.
Antonie Van Leeuwenhoek
75
41-78
0
Penicillium chrysogenum, Aspergillus nidulans
Automatic Mining of ENzyme DAta
Petrich, AK; Leskiw, BK; Paradkar, AS; Jensen, SE
Transcriptional mapping of the genes encoding the early enzymes of the cephamycin biosynthetic pathway of Streptomyces clavuligerus.
Gene
142
41-8
1994
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Brakhage, AA; Turner, G
L-lysine repression of penicillin biosynthesis and the expression of penicillin biosynthesis genes acvA and ipnA in Aspergillus nidulans.
FEMS Microbiol Lett
77
123-7
1992
Aspergillus nidulans
Automatic Mining of ENzyme DAta
Brakhage, AA; Browne, P; Turner, G
Regulation of Aspergillus nidulans penicillin biosynthesis and penicillin biosynthesis genes acvA and ipnA by glucose.
J Bacteriol
174
3789-99
1992
Aspergillus nidulans
Automatic Mining of ENzyme DAta
Demain, AL; Piret, JM; Yu, H; Coque, JJ; Liras, P; Martin, JF
Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus.
Ann N Y Acad Sci
721
117-22
1994
Streptomyces clavuligerus
Automatic Mining of ENzyme DAta
Brakhage, AA; Browne, P; Turner, G
Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted disruption of the acvA gene.
Mol Gen Genet
242
57-64
1994
Aspergillus nidulans
Automatic Mining of ENzyme DAta
Kim, CF; Lee, SK; Price, J; Jack, RW; Turner, G; Kong, RY
Cloning and expression analysis of the pcbAB-pcbC beta-lactam genes in the marine fungus Kallichroma tethys.
Appl Environ Microbiol
69
1308-14
2003
Kallichroma tethys, Aspergillus nidulans
Automatic Mining of ENzyme DAta
Martín, JF
Transport systems, intracellular traffic of intermediates and secretion of ?-lactam antibiotics in fungi.
Fungal Biol Biotechnol
7
6
2020
Penicillium chrysogenum, Aspergillus nidulans
Automatic Mining of ENzyme DAta
Thomès, L; Lescure, A
Mosaic Evolution of the Phosphopantothenate Biosynthesis Pathway in Bacteria and Archaea.
Genome Biol Evol
13
2021
Archaea, Bacteria, Candidatus Poribacteria, Picrophilus torridus
Automatic Mining of ENzyme DAta
Zhang, JY; Demain, AL
Regulation of ACV synthetase: biosynthesis and action.
Chin J Biotechnol
6
1-9
1990
Streptomyces clavuligerus, Acremonium
Automatic Mining of ENzyme DAta
Martin, JF
Clusters of genes for the biosynthesis of antibiotics: regulatory genes and overproduction of pharmaceuticals.
J Ind Microbiol
9
73-90
0
Penicillium chrysogenum, Aspergillus nidulans
Automatic Mining of ENzyme DAta